Results 71 to 80 of about 324,242 (283)

Editorial: Molecular mechanism of neuroimmune modulation and synaptic plasticity in acute and chronic pain [PDF]

, 2023
Linlin Zhang, Xin Zhang, Zilong Wang, Yize Li   +3 more
openalex   +1 more source

Neuropsychiatric Symptoms Mimicking Dementia in a Patient Treated With Imatinib

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Tyrosine kinase inhibitors are the cornerstone of chronic myeloid leukemia treatment. Newer agents have more potency and a broader spectrum of action, but also a higher potential for neuropsychiatric side effects. We present a case of a patient on imatinib who developed progressive cognitive, mood, and behavioral alterations.
Ashley Jones, Samuele Bonomi, Keith E. Stockerl‐Goldstein, Randall J. Bateman   +3 more
wiley   +1 more source

A rapamycin-sensitive signaling pathway contributes to long-term synaptic plasticity in the hippocampus [PDF]

, 2002
Many forms of long-lasting behavioral and synaptic plasticity require the synthesis of new proteins. For example, long-term potentiation (LTIP) that endures for more than an hour requires both transcription and translation.
Gingras, Anne-Claude, Kang, Hyejin, Reis, Gerald, Schuman, Erin M., Sonenberg, Nahum, Tang, Shao Jun   +5 more
core  

Enhanced Switching Performance in Single‐Crystalline PbTiO3 Ferroelectric Memristors for Replicating Synaptic Plasticity

Advanced Functional Materials, EarlyView.
This study demonstrated single‐crystalline PbTiO3‐based memristors with atomically sharp interfaces, well‐ordered lattices, and minimal lattice mismatch. The devices exhibited an ON/OFF ratio exceeding 105, high stability, and rich resistance‐state modulation.
Haining Li, Zhiqiang Liao, Risa Kataoka, Md Sarker Shamim, Takeshi Kijima, Hiroyasu Yamahara, Hitoshi Tabata, Munetoshi Seki   +7 more
wiley   +1 more source

Analysis of the intraspinal calcium dynamics and its implications on the plasticity of spiking neurons

, 2003
The influx of calcium ions into the dendritic spines through the N-metyl-D-aspartate (NMDA) channels is believed to be the primary trigger for various forms of synaptic plasticity.
A. Artola, B.L. Sabatini, C. Racca, C.E. Jahr, D.E. Feldman, D.E. Feldman, G. Bi, G. Carmignoto, G.C. Castellani, Gastone C. Castellani, H. Markram, H. Markram, H.D. Abarbanel, H.Z. Shouval, H.Z. Shouval, Harel Z. Shouval, J.A. Cummings, J.A. Lisman, J.C. Magee, Luk C. Yeung, M. Nishiyama, M.E. Larkum, M.F. Bear, M.F. Bear, N. Levy, P.J. Sjöström, R. Kempter, S. Song, S.M. Dudek, S.N. Yang, T. Kitajima, T.V.P. Bliss, U.R. Karmarkar, V.N. Murthy, W. Senn   +34 more
core   +1 more source

An Ultra‐Robust Memristor Based on Vertically Aligned Nanocomposite with Highly Defective Vertical Channels for Neuromorphic Computing

Advanced Functional Materials, EarlyView.
An ultra‐robust memristor based on SrTiO3‐CeO2 (S‐C) vertically aligned nanocomposite (VAN) achieving exceptional endurance of 1012 switching cycles via interface engineering. Artificial neural networks (ANNs) integrated with S‐C VAN memristors exhibit high training accuracy across multiple datasets.
Zedong Hu, Hongyi Dou, Jeremy B. Gan, Cun Li, Xuanyu Sheng, Juanjuan Lu, Abhijeet Choudhury, Jialong Huang, Yizhi Zhang, Zhongxia Shang, Ye Cao, Xinghang Zhang, Haiyan Wang   +12 more
wiley   +1 more source

Developmental and Activity Dependent Regulation of Ionotropic Glutamate Receptors at Synapses

The Scientific World Journal, 2002
Glutamate receptors mediate the majority of excitatory responses in the central nervous system. The establishment and refinement of glutamatergic synaptic connections depend on the concerted actions of a-amino-3-hydroxy-5-methyl-isoxazole-4-propionate ...
Elek Molnar, John T.R. Isaac
doaj   +1 more source

Elevated protein synthesis in microglia causes autism-like synaptic and behavioral aberrations

Nature Communications, 2020
The main cell types involved in autism spectrum disorders through elevated protein synthesis are not well identified. Here, the authors show that overexpression of translation initiation factor eIF4E in microglia results in autism-like behaviour in male,
Zhi-Xiang Xu, Gyu Hyun Kim, Ji-Wei Tan, Anna E. Riso, Ye Sun, Ethan Y. Xu, Guey-Ying Liao, Haifei Xu, Sang-Hoon Lee, Na-Young Do, Chan Hee Lee, Amy E. Clipperton-Allen, Soonwook Kwon, Damon T. Page, Kea Joo Lee, Baoji Xu   +15 more
doaj   +1 more source

Neonatal inflammation increases hippocampal KCC2 expression through methylation-mediated TGF-β1 downregulation leading to impaired hippocampal cognitive function and synaptic plasticity in adult mice [PDF]

, 2023
Jing Rong, Yang Yang, Min Liang, Haiquan Zhong, Yingchun Li, Yichao Zhu, Sha Sha, Lei Chen, Rong Zhou   +8 more
openalex   +1 more source

Dynamic Control of Synaptic Plasticity by Competing Ferroelectric and Trap‐Assisted Switching in IGZO Transistors with Al2O3/HfO2 Dielectrics

Advanced Functional Materials, EarlyView.
A frequency‐tunable ferroelectric synaptic transistor based on a buried‐gate InGaZnO channel and Al2O3/HfO2 dielectric stack exhibits linear and reversible weight updates using single‐polarity pulses. By switching between ferroelectric and trap‐assisted modes depending on input frequency, the device simplifies neuromorphic circuit design and achieves ...
Ojun Kwon, Dong Ho Lee, Seyoung Oh, Jongwon Yoon, Hyo‐Bae Kim, Ji‐Hoon Ahn, Woojin Park, Han Seul Kim, Byungjin Cho   +8 more
wiley   +1 more source