Results 1 to 10 of about 2,550,854 (361)
A theory of synaptic transmission [PDF]
eLife, 2021 Rapid and precise neuronal communication is enabled through a highly synchronous release of signaling molecules neurotransmitters within just milliseconds of the action potential.
Bin Wang, Olga K Dudko
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Frontiers in Synaptic Neuroscience, 2020 AMPA receptors (AMPARs) are glutamate-gated ion channels that mediate the majority of fast excitatory synaptic transmission throughout the brain. Changes in the properties and postsynaptic abundance of AMPARs are pivotal mechanisms in synaptic plasticity,
Hongyu Zhang, Clive R. Bramham
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Pre-post synaptic alignment through neuroligin-1 tunes synaptic transmission efficiency
eLife, 2018 The nanoscale organization of neurotransmitter receptors regarding pre-synaptic release sites is a fundamental determinant of the synaptic transmission amplitude and reliability.
Kalina T Haas +9 more
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Modulation of synaptic transmission through O-GlcNAcylation [PDF]
Molecular BrainO-GlcNAcylation is a posttranslational modification where N-acetylglucosamine (O-GlcNAc) is attached and detached from a serine/threonine position by two enzymes: O-GlcNAc transferase and O-GlcNAcase.
Seunghyo Han +5 more
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Harvard Data Science Review, 2018 In this chapter, we will first discuss chemical synapses, which use chemical signaling to convey information between the pre- and postsynaptic neurons, and then we will look at electrical synapses, which are a more basic but important second type of synapse that relies on direct electrical signaling.
Flavio Fröhlich
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Synaptic adhesion molecules and excitatory synaptic transmission
Current Opinion in Neurobiology, 2017 Synaptic adhesion molecules have been extensively studied for their contribution to the regulation of synapse development through trans-synaptic adhesions. However, accumulating evidence increasingly indicates that synaptic adhesion molecules are also involved in the regulation of excitatory synaptic transmission and plasticity, often through direct or
Seil Jang, Hyejin Lee, Eunjoon Kim
semanticscholar +4 more sources
ERRα regulates synaptic transmission through reactive oxygen species in hippocampal neurons [PDF]
HeliyonReactive oxygen species (ROS) play multiple roles in synaptic transmission, and estrogen-related receptor α (ERRα) is involved in regulating ROS production.
De-Mei Xu +4 more
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Minireview: pH and synaptic transmission [PDF]
FEBS Letters, 2013 As a general rule a rise in pH increases neuronal activity, whereas it is dampened by a fall of pH. Neuronal activity per se also challenges pH homeostasis by the increase of metabolic acid equivalents. Moreover, the negative membrane potential of neurons promotes the intracellular accumulation of protons.
A. Sinning, C. Hübner
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Turbocharging synaptic transmission
FEBS Letters, 2023 Evidence from biochemistry, genetics, and electron microscopy strongly supports the idea that a ring of Synaptotagmin is central to the clamping and release of synaptic vesicles (SVs) for synchronous neurotransmission. Recent direct measurements in cell‐free systems suggest there are 12 SNAREpins in each ready‐release vesicle, consisting of six ...
James E. Rothman +3 more
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