Results 1 to 10 of about 297,438 (167)

Actin maintains synaptic transmission by restraining vesicle release probability [PDF]

iScience
Summary: Despite decades of pharmacological studies, how the ubiquitous cytoskeletal actin regulates synaptic transmission remains poorly understood. We addressed this issue with a tissue-specific knockout of actin β-isoform or γ-isoform, combined with ...
Xin-Sheng Wu, Zhen Zhang, Yinghui Jin, Afreen Mushtaheed, Ling-Gang Wu   +4 more
doaj   +2 more sources

Cell-autonomous GABAARs are essential for NMDAR-mediated synaptic transmission, LTP, and spatial memory [PDF]

EMBO Reports
GABAA receptors (GABAARs) mediate most synaptic inhibition in the brain, but their cell-autonomous role in regulating glutamatergic transmission remains poorly understood.
Jing-jing Duan, Bin Jiang, Wei Yin, Yuan Lin, Guang-mei Yan, Wei Lu   +5 more
doaj   +2 more sources

Synaptic Transmission

Harvard Data Science Review, 2018
Flavio Fröhlich
doaj   +2 more sources

Turbocharging synaptic transmission

FEBS Letters, 2023
Evidence from biochemistry, genetics, and electron microscopy strongly supports the idea that a ring of Synaptotagmin is central to the clamping and release of synaptic vesicles (SVs) for synchronous neurotransmission. Recent direct measurements in cell‐free systems suggest there are 12 SNAREpins in each ready‐release vesicle, consisting of six ...
James E. Rothman, Kirill Grushin, Manindra Bera, Frederic Pincet   +3 more
openaire   +3 more sources

Retraction Note: Reprogramming glioblastoma multiforme cells into neurons by protein kinase inhibitors

Journal of Experimental & Clinical Cancer Research, 2021
This article has been retracted.
Jie Yuan, Fan Zhang, Dennis Hallahan, Zhen Zhang, Liming He, Ling-Gang Wu, Meng You, Qin Yang   +7 more
doaj   +1 more source

The role of thrombin in early-onset seizures

Frontiers in Cellular Neuroscience, 2023
A variety of clinical observations and studies in animal models of temporal lobe epilepsy (TLE) reveal dysfunction of blood-brain barrier (BBB) during seizures.
Alina Savotchenko, Mariia Klymenko, Mariia Shypshyna, Dmytro Isaev   +3 more
doaj   +1 more source

Synaptic actions of amyotrophic-lateral-sclerosis-associated G85R-SOD1 in the squid giant synapse [PDF]

, 2020
© The Author(s), 2020. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Song, Y.
Song, Yuyu
core   +1 more source

A Common Human Brain-Derived Neurotrophic Factor Polymorphism Leads to Prolonged Depression of Excitatory Synaptic Transmission by Isoflurane in Hippocampal Cultures

Frontiers in Molecular Neuroscience, 2022
Multiple presynaptic and postsynaptic targets have been identified for the reversible neurophysiological effects of general anesthetics on synaptic transmission and neuronal excitability. However, the synaptic mechanisms involved in persistent depression
Riley A. Williams, Kenneth W. Johnson, Francis S. Lee, Francis S. Lee, Francis S. Lee, Hugh C. Hemmings, Hugh C. Hemmings, Jimcy Platholi, Jimcy Platholi   +8 more
doaj   +1 more source

An ex vivo Model of Paired Cultured Hippocampal Neurons for Bi-directionally Studying Synaptic Transmission and Plasticity

Bio-Protocol, 2023
Synapses provide the main route of signal transduction within neuronal networks. Many factors regulate critical synaptic functions. These include presynaptic calcium channels, triggering neurotransmitter release, and postsynaptic ionotropic receptors ...
Ruslan Stanika, Gerald Obermair
doaj   +1 more source

The CaMKII/NMDA receptor complex controls hippocampal synaptic transmission by kinase-dependent and independent mechanisms. [PDF]

, 2018
CaMKII is one of the most studied synaptic proteins, but many critical issues regarding its role in synaptic function remain unresolved. Using a CRISPR-based system to delete CaMKII and replace it with mutated forms in single neurons, we have rigorously ...
Asensio, Cedric S, Bender, Kevin J, Díaz-Alonso, Javier, Iafrati, Jillian, Incontro, Salvatore, Nicoll, Roger A, Roche, Katherine W, Sohal, Vikaas S, Vieira, Marta   +8 more
core   +2 more sources