Bidirectional Dysregulation of AMPA Receptor-Mediated Synaptic Transmission and Plasticity in Brain Disorders [PDF]
Frontiers in Synaptic Neuroscience, 2020 AMPA receptors (AMPARs) are glutamate-gated ion channels that mediate the majority of fast excitatory synaptic transmission throughout the brain. Changes in the properties and postsynaptic abundance of AMPARs are pivotal mechanisms in synaptic plasticity,
Hongyu Zhang, Clive R. Bramham
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The CaMKII/NMDA receptor complex controls hippocampal synaptic transmission by kinase-dependent and independent mechanisms. [PDF]
Nature Communications, 2018 CaMKII is one of the most studied synaptic proteins, but many critical issues regarding its role in synaptic function remain unresolved. Using a CRISPR-based system to delete CaMKII and replace it with mutated forms in single neurons, we have rigorously ...
Asensio, Cedric S +8 more
core +3 more sources
A theory of synaptic transmission [PDF]
eLife, 2021 Rapid and precise neuronal communication is enabled through a highly synchronous release of signaling molecules neurotransmitters within just milliseconds of the action potential.
Bin Wang, Olga K Dudko
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Harvard Data Science Review, 2018 In this chapter, we will first discuss chemical synapses, which use chemical signaling to convey information between the pre- and postsynaptic neurons, and then we will look at electrical synapses, which are a more basic but important second type of synapse that relies on direct electrical signaling.
Flavio Fröhlich
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Thermal Impact on Spiking Properties in Hodgkin-Huxley Neuron with Synaptic Stimulus [PDF]
, 2007 The effect of environmental temperature on neuronal spiking behaviors is investigated by numerically simulating the temperature dependence of spiking threshold of the Hodgkin-Huxley neuron subject to synaptic stimulus. We find that the spiking threshold exhibits a global minimum in a "comfortable temperature" range where spike initiation needs weakest ...
A. F. Huxley +28 more
arxiv +4 more sources
Methamphetamine reduces LTP and increases baseline synaptic transmission in the CA1 region of mouse hippocampus. [PDF]
PLoS ONE, 2010 Methamphetamine (METH) is an addictive psychostimulant whose societal impact is on the rise. Emerging evidence suggests that psychostimulants alter synaptic plasticity in the brain--which may partly account for their adverse effects.
Jarod Swant +3 more
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Actin maintains synaptic transmission by restraining vesicle release probability [PDF]
iScienceSummary: Despite decades of pharmacological studies, how the ubiquitous cytoskeletal actin regulates synaptic transmission remains poorly understood. We addressed this issue with a tissue-specific knockout of actin β-isoform or γ-isoform, combined with ...
Xin-Sheng Wu +4 more
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Pre-post synaptic alignment through neuroligin-1 tunes synaptic transmission efficiency
eLife, 2018 The nanoscale organization of neurotransmitter receptors regarding pre-synaptic release sites is a fundamental determinant of the synaptic transmission amplitude and reliability.
Kalina T Haas +9 more
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Formation and Stability of Synaptic Receptor Domains [PDF]
Phys. Rev. Lett. 106, 238104 (2011), 2010 Neurotransmitter receptor molecules, concentrated in postsynaptic domains along with scaffold and a number of other molecules, are key regulators of signal transmission across synapses. Employing experiment and theory, we develop a quantitative description of synaptic receptor domains in terms of a reaction-diffusion model.
Antoine Triller +5 more
arxiv +6 more sources
Astroglia-Derived BDNF and MSK-1 Mediate Experience- and Diet-Dependent Synaptic Plasticity [PDF]
Brain Sciences, 2020 Experience- and diet-dependent regulation of synaptic plasticity can underlie beneficial effects of active lifestyle on the aging brain. Our previous results demonstrate a key role for brain-derived neurotrophic factor (BDNF) and MSK1 kinase in ...
Ulyana Lalo +3 more
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