Results 1 to 10 of about 169,161 (276)

Actin maintains synaptic transmission by restraining vesicle release probability [PDF]

iScience
Summary: Despite decades of pharmacological studies, how the ubiquitous cytoskeletal actin regulates synaptic transmission remains poorly understood. We addressed this issue with a tissue-specific knockout of actin β-isoform or γ-isoform, combined with ...
Xin-Sheng Wu, Zhen Zhang, Yinghui Jin, Afreen Mushtaheed, Ling-Gang Wu   +4 more
doaj   +2 more sources

Effect of Noradrenaline on the Facial Stimulation-Evoked Mossy Fiber-Granule Cell Synaptic Transmission in Mouse Cerebellar Cortex

Frontiers in Neuroscience, 2021
Noradrenaline is an important neuromodulator in the cerebellum. We previously found that noradrenaline depressed cerebellar Purkinje cell activity and climbing fiber–Purkinje cell synaptic transmission in vivo in mice.
Bing-Xue Li, Bing-Xue Li, Hua Jin, Hua Jin, Guang-Jian Zhang, Guang-Jian Zhang, Li-Na Cui, Li-Na Cui, Chun-Ping Chu, Chun-Ping Chu, De-Lai Qiu, De-Lai Qiu   +11 more
doaj   +2 more sources

Inferring synaptic transmission from the stochastic dynamics of the quantal content: An analytical approach. [PDF]

PLoS Comput Biol
Vahdat Z, Gambrell O, Fisch J, Friauf E, Singh A.   +4 more
europepmc   +2 more sources

Correction: The C-terminal of CASY-1/Calsyntenin regulates GABAergic synaptic transmission at the Caenorhabditis elegans neuromuscular junction. [PDF]

PLoS Genet
Thapliyal S, Vasudevan A, Dong Y, Bai J, Koushika SP, Babu K.   +5 more
europepmc   +3 more sources

Synaptic Transmission

Harvard Data Science Review, 2018
Flavio Fröhlich
doaj   +2 more sources

Turbocharging synaptic transmission

FEBS Letters, 2023
Evidence from biochemistry, genetics, and electron microscopy strongly supports the idea that a ring of Synaptotagmin is central to the clamping and release of synaptic vesicles (SVs) for synchronous neurotransmission. Recent direct measurements in cell‐free systems suggest there are 12 SNAREpins in each ready‐release vesicle, consisting of six ...
James E. Rothman, Kirill Grushin, Manindra Bera, Frederic Pincet   +3 more
openaire   +3 more sources

Propofol regulates arousal by enhancing inhibitory synaptic transmission of noradrenergic neurons in the locus coeruleus of adult male mice. [PDF]

Sci Rep
Abe T, Kurabe M, Nakamura Y, Sasaki M, Seino Y, Furutani K, Ueno M, Baba H.   +7 more
europepmc   +3 more sources

Retraction Note: Reprogramming glioblastoma multiforme cells into neurons by protein kinase inhibitors

Journal of Experimental & Clinical Cancer Research, 2021
This article has been retracted.
Jie Yuan, Fan Zhang, Dennis Hallahan, Zhen Zhang, Liming He, Ling-Gang Wu, Meng You, Qin Yang   +7 more
doaj   +1 more source

The role of thrombin in early-onset seizures

Frontiers in Cellular Neuroscience, 2023
A variety of clinical observations and studies in animal models of temporal lobe epilepsy (TLE) reveal dysfunction of blood-brain barrier (BBB) during seizures.
Alina Savotchenko, Mariia Klymenko, Mariia Shypshyna, Dmytro Isaev   +3 more
doaj   +1 more source

A Common Human Brain-Derived Neurotrophic Factor Polymorphism Leads to Prolonged Depression of Excitatory Synaptic Transmission by Isoflurane in Hippocampal Cultures

Frontiers in Molecular Neuroscience, 2022
Multiple presynaptic and postsynaptic targets have been identified for the reversible neurophysiological effects of general anesthetics on synaptic transmission and neuronal excitability. However, the synaptic mechanisms involved in persistent depression
Riley A. Williams, Kenneth W. Johnson, Francis S. Lee, Francis S. Lee, Francis S. Lee, Hugh C. Hemmings, Hugh C. Hemmings, Jimcy Platholi, Jimcy Platholi   +8 more
doaj   +1 more source