Results 31 to 40 of about 2,725,603 (391)
Conversion of Fibroblasts to Neural Cells by p53 Depletion
Cell Reports, 2014 Conversion from fibroblasts to neurons has recently been successfully induced. However, the underlying mechanisms are poorly understood. Here, we find that depletion of p53 alone converts fibroblasts into all three major neural lineages.
Di Zhou +11 more
doaj +1 more source
Science, 2019 A physiological function for sAPP? Although the pathological role of the amyloid-β precursor protein (APP) in Alzheimer's disease is well studied, the physiological role of this protein has remained elusive. Rice et al. found that the secreted ectodomain
Heather C. Rice +18 more
semanticscholar +1 more source
eLife, 2016 Mouse CA1 pyramidal neurons express apamin-sensitive SK2-containing channels in the post-synaptic membrane, positioned close to NMDA-type (N-methyl-D-aspartate) glutamate receptors.
Gukhan Kim +8 more
doaj +1 more source
Frontiers in Molecular Neuroscience, 2022 Chronic Postsurgical Pain (CPSP) is well recognized to impair cognition, particularly memory. Mounting evidence suggests anatomic and mechanistic overlap between pain and cognition on several levels.
Zhen Li +5 more
doaj +1 more source
Photons guided by axons may enable backpropagation-based learning in the brain [PDF]
Sci Rep 12, 20720 (2022), 2022 Despite great advances in explaining synaptic plasticity and neuron function, a complete understanding of the brain's learning algorithms is still missing. Artificial neural networks provide a powerful learning paradigm through the backpropagation algorithm which modifies synaptic weights by using feedback connections.
arxiv +1 more source
Amyloid-β acts as a regulator of neurotransmitter release disrupting the interaction between synaptophysin and VAMP2. [PDF]
, 2012 BACKGROUND: It is becoming increasingly evident that deficits in the cortex and hippocampus at early stages of dementia in Alzheimer's disease (AD) are associated with synaptic damage caused by oligomers of the toxic amyloid-β peptide (Aβ42).
Alifragis, P +5 more
core +2 more sources
Stochastic lattice model of synaptic membrane protein domains [PDF]
Phys. Rev. E 95, 052406 (2017), 2017 Neurotransmitter receptor molecules, concentrated in synaptic membrane domains along with scaffolds and other kinds of proteins, are crucial for signal transmission across chemical synapses. In common with other membrane protein domains, synaptic domains are characterized by low protein copy numbers and protein crowding, with rapid stochastic turnover ...
arxiv +1 more source
Molecular Noise In Synaptic Communication [PDF]
, 2022 In synaptic molecular communication (MC), the activation of postsynaptic receptors by neurotransmitters (NTs) is governed by a stochastic reaction-diffusion process. This randomness of synaptic MC contributes to the randomness of the electrochemical downstream signal in the postsynaptic cell, called postsynaptic membrane potential (PSP).
arxiv +1 more source
Gain modulation of synaptic inputs by network state in auditory cortex in vivo [PDF]
, 2015 The cortical network recurrent circuitry generates spontaneous activity organized into Up (active) and Down (quiescent) states during slow-wave sleep or anesthesia.
Destexhe, Alain +4 more
core +3 more sources
Turbocharging synaptic transmission
FEBS Letters, 2023 Evidence from biochemistry, genetics, and electron microscopy strongly supports the idea that a ring of Synaptotagmin is central to the clamping and release of synaptic vesicles (SVs) for synchronous neurotransmission. Recent direct measurements in cell‐free systems suggest there are 12 SNAREpins in each ready‐release vesicle, consisting of six ...
James E. Rothman +3 more
openaire +2 more sources