Results 191 to 200 of about 107,361 (347)

Translocation of cytosolic acetylcholine into synaptic vesicles and demonstration of vesicular release.

, 1986
D. M. Michaelson, M. Burstein, Roxana Licht   +2 more
openalex   +1 more source

New insights into epileptic spasm generation and treatment from the TTX animal model

Epilepsia Open, EarlyView.
Abstract Currently, we have an incomplete understanding of the mechanisms underlying infantile epileptic spasms syndrome (IESS). However, over the past decade, significant efforts have been made to develop IESS animal models to provide much‐needed mechanistic information for therapy development.
John W. Swann, Carlos J. Ballester‐Rosado, Chih‐Hong Lee   +2 more
wiley   +1 more source

α-Synuclein-Assembled Synaptic Vesicle Pools at the Presynaptic Terminal: A Study of α-Synuclein Function Using a Novel Mouse Model. [PDF]

Acta Histochem Cytochem
Suzuki C, Yamaguchi J, Tanida I, Uchiyama Y.   +3 more
europepmc   +2 more sources

APOE4 triggers dysregulated synaptic vesicle release by disrupting SNARE complex assembly. [PDF]

Cell Mol Life Sci
Chen F, Chen Y, Feng S, Chen H, Deng L, Ma F, Ke Q, Liang Q, Chen J, Peng X, Lu J, Liu Y, Xie Y, Cao H, Sun Y, Wu W, Cui L, Wang Y.   +17 more
europepmc   +1 more source

L-glutamate stimulation of Na+ efflux from brain synaptic membrane vesicles.

, 1981
H. H. Chang, Elias K. Michaelis
openalex   +1 more source

The upside of epilepsy: Theories of an evolutionary paradox

Epilepsia Open, EarlyView.
Abstract The persistence of common, heritable conditions, like epilepsy, that are associated with reduced reproductive fitness is an evolutionary paradox. Endogenous analgesic, anti‐depressant, and inflammatory mechanisms able to repair compromised functions can offer advantages in unexpected crises.
Alyssa Ailion, Christoph Helmstaedter, Annamaria Vezzani, Matthias J. Koepp   +3 more
wiley   +1 more source

Pathways to Progressive Disability in Multiple Sclerosis: The Role of Glial Cells in Chronic CNS Inflammation

Glia, EarlyView.
ABSTRACT Multiple sclerosis (MS) is the most common non‐infectious inflammatory CNS disease, characterized by progressive neurodegeneration and focal demyelinated lesions. Traditionally considered an autoimmune disease, MS is driven by the immune system's attack on CNS myelin, resulting in cumulative disability.
Volker Siffrin
wiley   +1 more source

Dynamic regulation of vesicle pools in a detailed spatial model of the complete synaptic vesicle cycle. [PDF]

Sci Adv
Gallimore AR, Hepburn I, Georgiev SV, Rizzoli SO, De Schutter E.   +4 more
europepmc   +1 more source

SVOP, an Evolutionarily Conserved Synaptic Vesicle Protein, Suggests Novel Transport Functions of Synaptic Vesicles [PDF]

, 1998
Roger Janz, Kay Hofmann, Thomas C. Südhof   +2 more
openalex   +1 more source

Impaired Volume Regulation and Electrophysiology of Astrocytes In Situ in a Mouse Model for Megalencephalic Leukoencephalopathy With Subcortical Cysts

Glia, EarlyView.
Cell culture studies show disrupted astrocyte physiology in the leukodystrophy MLC. Are intact astrocytes similarly affected? This study on astrocytes in MLC mouse brain slices confirms and extends in vitro studies on altered astrocyte physiology. ABSTRACT Electrical signaling, driven by ion fluxes between intra‐ and extracellular compartments, is ...
Sven Kerst, Nina Meesters, Tim S. Heistek, Marjo S. van der Knaap, Huibert D. Mansvelder, Rogier Min   +5 more
wiley   +1 more source