Results 281 to 290 of about 107,361 (347)

Chromosome‐Level Genome Assembly of the Loach Goby Rhyacichthys aspro Offers Insights Into Gobioidei Evolution

Molecular Ecology Resources, EarlyView.
ABSTRACT The percomorph fish clade Gobioidei is a suborder that comprises over 2200 species distributed in nearly all aquatic habitats. To understand the genetics underlying their species diversification, we sequenced and annotated the genome of the loach goby, Rhyacichthys aspro, an early‐diverging group, and compared it with nine additional Gobioidei
Tzi‐Yuan Wang, Yu‐Wei Wu, Hao‐Jun Lu, Te‐Yu Liao, Jui‐Hung Tai, Shih‐Pin Huang, Feng‐Yu Wang, Tsung‐Han Yu, Chau‐Ti Ting, Shu‐Miaw Chaw, Hurng‐Yi Wang   +10 more
wiley   +1 more source

GMP-compliant automated radiosynthesis of [¹⁸F] SynVesT-1 for PET imaging of synaptic vesicle glycoprotein 2 A (SV2A). [PDF]

EJNMMI Radiopharm Chem
Chen L, Li X, Ge Y, Li H, Li R, Song X, Liang J, Zhang W, Li X, Wang X, Wang Y, Wu Y, Bai Y, Wang M.   +13 more
europepmc   +1 more source

The Proprotein Convertase BLI‐4 Is Required for Axenic Dietary Restriction Mediated Longevity in Caenorhabditis elegans

Aging Cell, EarlyView.
In ADR‐induced longevity in C. elegans, neuronal BLI‐4 processes neuropeptides, which are then released with the assistance of UNC‐31 and GOLG‐2. ABSTRACT Dietary restriction (DR) is a well‐established method for extending lifespan across various species, including C. elegans.
Ping Wu, Lieselot Vandemeulebroucke, Huaihan Cai, Bart P. Braeckman   +3 more
wiley   +1 more source

Synaptic vesicle pool heterogeneity drives an anomalous form of synaptic plasticity. [PDF]

Proc Natl Acad Sci U S A
Guzikowski NJ, Kavalali ET.
europepmc   +1 more source

Age‐Associated Decline in Autophagy Pathways in the Retinal Pigment Epithelium and Protective Effects of Topical Trehalose in Light‐Induced Outer Retinal Degeneration in Mice

Aging Cell, EarlyView.
Transcriptomic analyses reveal an age‐related decline in autophagy pathways in RPE/choroid. These pathways remain unchanged in early AMD but become bidirectionally dysregulated in later stages, along with increased RPE loss. Pre‐treatment with trehalose eyedrops enhances RPE autophagy flux and prevents light‐induced outer retinal degeneration in mice ...
Katherine Cox, Gongyu Shi, Neve Read, Mohamed T. Patel, Kepeng Ou, Zijia Liu, Jiahui Wu, Suci Cendanawati, Jenna Le Brun Powell, Pola Goldberg Oppenheimer, Lisa J. Hill, Lindsay B. Nicholson, Andrew D. Dick, Jian Liu   +13 more
wiley   +1 more source

Presynaptic cAMP-PKA-mediated potentiation induces reconfiguration of synaptic vesicle pools and channel-vesicle coupling at hippocampal mossy fiber boutons. [PDF]

PLoS Biol
Kim O, Okamoto Y, Kaufmann WA, Brose N, Shigemoto R, Jonas P.   +5 more
europepmc   +1 more source

The role of auditory sensory input during functional pre- and postsynaptic maturation of the calyx of Held synapse. [PDF]

, 2007
Erazo Fischer, E.
core   +1 more source

Accumulation of GSK‐3β in Interneurons Impairs Adult Hippocampal Neurogenesis by Inhibiting GABAergic Transmission

Aging Cell, EarlyView.
Overexpression of GSK‐3β in DG GABAergic neurons impairs neurogenesis by reducing GABA release, which can be reversed by enhancing GABAergic transmission. ABSTRACT The activation of glycogen synthase kinase 3β (GSK‐3β) and the deterioration of spatial memory represent prominent pathological and clinical manifestations of Alzheimer's disease (AD ...
Fei Liu, Jiu‐Jing Cui, Xiao‐Lin Li, Zeng‐Min Zhang, Shao‐Hua Liang, Yi Sun, Jing‐Min Li, Hong‐Lin Qu, Jing Ye, Qi‐Peng Guo, Quan Zheng, Yong‐Feng Liu   +11 more
wiley   +1 more source

Interplay between Copper, Phosphatidylserine, and α-Synuclein Suggests a Link between Copper Homeostasis and Synaptic Vesicle Cycling. [PDF]

ACS Chem Neurosci
Teng X, Stefaniak E, Willison KR, Ying L.   +3 more
europepmc   +1 more source

Regenerative Response 35 Days After Esophageal Replacement in a Porcine Model; Technical Difficulties and Attempts to Achieve Optimal Tissue Remodeling

Artificial Organs, EarlyView.
ABSTRACT Background In previous articles, a porcine model for bridging circumferential defects in the intrathoracic esophagus was developed. The aims of this present study were to evaluate the continued healing response after 35 days, avoid stent migration of the esophageal stent, and to investigate whether it would be beneficial to add new ...
A. Sandin, L. Jönsson, E. Jennische, M. Dellenmark Blom, L.‐G. Friberg, V. Gatzinsky, O. Holmqvist, K. Abrahamsson   +7 more
wiley   +1 more source