Results 101 to 110 of about 53,467 (282)

Hijacking the Host Clock: A Nematode Effector Antagonizes Soybean Circadian Defense and Translation Control

Advanced Science, EarlyView.
Soybean employs its circadian clock, governed by GmCCA1, to rhythmically defend against soybean cyst nematodes. The pathogen retaliates by secreting the effector Hg4E02, which hijacks the clock to suppress defense and co‐opt the host's translation machinery for nutrient acquisition.
Xingwei Wang, Yufeng Xu, Yanfei Hu, Lijun Cao, Ru Jiang, Changtian Chen, Rick Masonbrink, Thomas Maier, Yuchen Tu, Yabo Shi, Enhui Liu, Lingan Kong, Chan Guo, Wei Zhao, Peng Shi, Wenzhen Du, Andrew Severin, Thomas Baum, Deliang Peng, Huan Peng, Mian Zhou, Wei Wang   +21 more
wiley   +1 more source

SNAP25 undergoes phase separation to facilitate the assembly of the synaptic vesicle fusion machinery

Cell Reports
Summary: The assembly of the SNARE complexes drives synaptic exocytosis in neurotransmission. SNAP25 is a key SNARE protein that pairs with syntaxin-1 and VAMP2 in synaptic vesicle fusion.
Min Zhu, Yulei Jin, Jintong Liu, Xiaoxu Kong, Yinghui Liu, Haijia Yu   +5 more
doaj   +1 more source

Accumulation of Dense Core Vesicles in Hippocampal Synapses Following Chronic Inactivity. [PDF]

, 2018
The morphology and function of neuronal synapses are regulated by neural activity, as manifested in activity-dependent synapse maturation and various forms of synaptic plasticity.
Bi, Guo-Qiang, Lau, Pak-Ming, Liu, Yun-Tao, Tao, Chang-Lu, Zhou, Z Hong   +4 more
core   +2 more sources

Synchrotron XRF Imaging Reveals Manganese Accumulation in the Golgi and Post‐Synapses of Neurons and Enhanced Uptake in Astrocytes

Advanced Science, EarlyView.
Despite widespread exposure, the mechanisms of manganese neurotoxicity remain poorly understood. Using correlative cryogenic fluorescence and synchrotron X‐ray fluorescence imaging techniques, we show that the Golgi apparatus is the primary accumulation site for manganese in both neurons and astrocytes, and that manganese targets the neuronal ...
Ines Kelkoul, Aiyarin Kittilukkana, Luis C. C. Huarte, Hiram Castillo‐Michel, Murielle Salome, Stéphane Roudeau, Pauline Belzanne, Matthieu Sainlos, Noémie Pied, Monica Fernandez‐Monreal, Daniel Choquet, Richard Ortega, Asuncion Carmona   +12 more
wiley   +1 more source

All-carbon multi-electrode array for real-time in vitro measurements of oxidizable neurotransmitters [PDF]

, 2016
We report on the ion beam fabrication of all-carbon multi electrode arrays (MEAs) based on 16 graphitic micro-channels embedded in single-crystal diamond (SCD) substrates.
Battiato, A., Bernardi, E., Carabelli, V., Carbone, E., Franchino, C., Gosso, S., Olivero, P., Pasquarelli, A., Picollo, F., Plaitano, M.   +9 more
core   +2 more sources

Regulation of synaptic vesicle fusion by protein kinase C

The Journal of Physiology, 1999
Activation of protein kinase C (PKC) by phorbol esters stimulates secretion of neurotransmitters from most presynaptic terminals. This action of PKC may be even more general, because secretion from many non-neuronal cells is also stimulated by these agents.
S, Hilfiker, G J, Augustine
openaire   +3 more sources

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Postsynaptic Complexin Mediates Constitutive Exocytosis of Nicotinic Acetylcholine Receptor

Advanced Science, EarlyView.
Beyond its established presynaptic role, complexin is identified as a postsynaptic regulator of neurotransmitter receptor trafficking. By promoting constitutive and activity‐dependent exocytosis of nicotinic acetylcholine receptors, complexin controls spontaneous synaptic signaling at the C.
Ya Wang, Yixiang Deng, Nan Xia, Shuzo Sugita, Shangbang Gao   +4 more
wiley   +1 more source

Differential Release of Exocytosis Marker Dyes Indicates Stimulation-Dependent Regulation of Synaptic Activity

Frontiers in Neuroscience, 2019
There is a general consensus that synaptic vesicular release by a full collapse process is the primary machinery of synaptic transmission. However, competing view suggests that synaptic vesicular release operates via a kiss-and-run mechanism.
Andreas W. Henkel, Abdeslam Mouihate, Oliver Welzel   +2 more
doaj   +1 more source

Nanoscale-targeted patch-clamp recordings of functional presynaptic ion channels [PDF]

, 2013
Important modulatory roles have been attributed to presynaptic NMDA receptors (NMDARs) located on cerebellar interneuron terminals. Evidence supporting a presynaptic location includes an increase in the frequency of mini events following the application ...
Benton, DCH, Caldwell, M, Moss, GWJ, Robertson, AD, Smart, TG   +4 more
core   +1 more source