Results 251 to 260 of about 53,467 (282)

SNARE Proteins in Synaptic Vesicle Fusion

2023
Neurotransmitters are stored in small membrane-bound vesicles at synapses; a subset of synaptic vesicles is docked at release sites. Fusion of docked vesicles with the plasma membrane releases neurotransmitters. Membrane fusion at synapses, as well as all trafficking steps of the secretory pathway, is mediated by SNARE proteins.
Mark T, Palfreyman, Sam E, West, Erik M, Jorgensen   +2 more
openaire   +2 more sources

Reconstituting Synaptic Vesicle Fusion

Science Signaling, 2013
A model of neurotransmitter release explains why two proteins not needed for membrane fusion in vitro are needed in vivo.
openaire   +2 more sources

pRIMing synaptic vesicles for fusion

Nature Neuroscience, 2001
A characterization of C. elegans lacking the gene for Rim suggests that this protein may be involved in priming synaptic vesicles for fusion, not in docking or organizing active zones.
Thomas E. Lloyd, Hugo J. Bellen
openaire   +1 more source

Snares and munc18 in synaptic vesicle fusion

Nature Reviews Neuroscience, 2002
The release of neurotransmitters by Ca2+-triggered synaptic vesicle exocytosis is an exquisitely regulated process that is fundamental for interneuronal communication. This process involves several steps and is controlled by a protein machinery that must prevent release before Ca2+ entry into presynaptic terminals, and yet must rapidly induce release ...
Josep, Rizo, Thomas C, Südhof
openaire   +2 more sources

Synaptic vesicle docking and fusion

Current Opinion in Neurobiology, 1999
Neurotransmitter secretion shares many features with constitutive membrane trafficking. In both cases, vesicles are targeted to a specific acceptor membrane and fuse via a series of protein-protein interactions. Recent work has added to the list of protein complexes involved and is beginning to define the order in which they act.
openaire   +2 more sources

Dynamics of synaptic vesicle fusion and membrane retrieval in synaptic terminals

Nature, 1994
Communication among neurons occurs at specialized synaptic junctions, where neurotransmitter is released via calcium-dependent exocytosis from the synaptic terminal of the presynaptic cell onto the postsynaptic target neuron. Here we exploit the unique properties of giant synaptic terminals of bipolar neurons from goldfish retina to establish the ...
H, von Gersdorff, G, Matthews
openaire   +2 more sources

Synaptic-vesicle fusion: a need for speed

Nature Structural & Molecular Biology, 2015
Two new studies reveal mechanistic insights into how neurons control the assembly of SNARE complexes and the rapid fusion of synaptic vesicles. Structural, biophysical and functional experiments are combined to elucidate the roles of two critical regulators: Munc13 and synaptotagmin.
openaire   +2 more sources

Evidence That Synaptobrevin Is Involved in Fusion between Synaptic Vesicles and Synaptic Plasma Membrane Vesicles

Biochemical and Biophysical Research Communications, 1997
We have developed a model system, consisting of rat brain synaptic vesicles and rat brain synaptic plasma membrane vesicles, to study the fusion process associated with the exocytotic release of neurotransmitters. Our results show a significant increase in the extent of fusion when the reaction takes place in cytosol compared to that obtained when ...
M T, Almeida, J, Ramalho-Santos, C R, Oliveira, M C, Pedroso de Lima   +3 more
openaire   +2 more sources

Axolemmal repair requires proteins that mediate synaptic vesicle fusion

Journal of Neurobiology, 2000
A damaged cell membrane is repaired by a seal that restricts entry or exit of molecules and ions to that of the level passing through an undamaged membrane. Seal formation requires elevation of intracellular Ca(2+) and, very likely, protein-mediated fusion of membranes. Ca(2+) also regulates the interaction between synaptotagmin (Syt) and syntaxin (Syx)
E, Detrait, C S, Eddleman, S, Yoo, M, Fukuda, M P, Nguyen, G D, Bittner, H M, Fishman   +6 more
openaire   +2 more sources

Coupling calcium to SNARE–mediated synaptic vesicle fusion

Nature Neuroscience, 1999
Calcium triggers vesicle fusion, but the molecular mechanism is largely unknown. Now Ilardi and colleagues identify Snapin, a protein that may provide the missing link.
Sabine Hilfiker, Paul Greengard, George J. Augustine   +2 more
openaire   +1 more source