Synaptic vesicle recycling: steps and principles. [PDF]
EMBO J, 2014 Synaptic vesicle recycling is one of the best‐studied cellular pathways. Many of the proteins involved are known, and their interactions are becoming increasingly clear.
Rizzoli SO.
europepmc +6 more sources
Septin Polymerization Slows Synaptic Vesicle Recycling in Motor Nerve Endings. [PDF]
Acta Naturae, 2019 Septins are GTP-binding proteins recognized as a component of the cytoskeleton. Despite the fact that septins are highly expressed by neurons and can interact with the proteins that participate in synaptic vesicle exocytosis and endocytosis, the role of ...
Grigoryev PN, Khisamieva GA, Zefirov AL.
europepmc +2 more sources
Endophilin-A regulates presynaptic Ca2+ influx and synaptic vesicle recycling in auditory hair cells. [PDF]
EMBO J, 2019 Ribbon synapses of cochlear inner hair cells (IHCs) operate with high rates of neurotransmission; yet, the molecular regulation of synaptic vesicle (SV) recycling at these synapses remains poorly understood. Here, we studied the role of endophilins‐A1‐3,
Kroll J +9 more
europepmc +2 more sources
Revisiting the Role of Clathrin-Mediated Endoytosis in Synaptic Vesicle Recycling. [PDF]
Front Cell Neurosci, 2018 Without robust mechanisms to efficiently form new synaptic vesicles (SVs), the tens to hundreds of SVs typically present at the neuronal synapse would be rapidly used up, even at modest levels of neuronal activity.
Milosevic I.
europepmc +2 more sources
Carbonic anhydrase inhibitor acetazolamide shifts synaptic vesicle recycling to a fast mode at the mouse neuromuscular junction [PDF]
Synapse, 2017 Acetazolamide (AZ), a molecule frequently used to treat different neurological syndromes, is an inhibitor of the carbonic anhydrase (CA), an enzyme that regulates pH inside and outside cells.
Bertone Cueto, Nicolás Iván +5 more
core +2 more sources
Triose-phosphate isomerase deficiency is associated with a dysregulation of synaptic vesicle recycling in Drosophila melanogaster [PDF]
Frontiers in Synaptic Neuroscience, 2023 IntroductionNumerous neurodegenerative diseases are associated with neuronal dysfunction caused by increased redox stress, often linked to aberrant production of redox-active molecules such as nitric oxide (NO) or oxygen free radicals.
Aelfwin Stone +6 more
doaj +2 more sources
Endophilin A and B Join Forces With Clathrin to Mediate Synaptic Vesicle Recycling in Caenorhabditis elegans. [PDF]
Front Mol Neurosci, 2018 Synaptic vesicle (SV) recycling enables ongoing transmitter release, even during prolonged activity. SV membrane and proteins are retrieved by ultrafast endocytosis and new SVs are formed from synaptic endosomes (large vesicles—LVs).
Yu SC +4 more
europepmc +2 more sources
The BLOC-1 Subunit Pallidin Facilitates Activity-Dependent Synaptic Vesicle Recycling. [PDF]
eNeuro, 2017 Membrane trafficking pathways must be exquisitely coordinated at synaptic terminals to maintain functionality, particularly during conditions of high activity.
Chen X +5 more
europepmc +2 more sources
Effects of the clathrin inhibitor Pitstop-2 on synaptic vesicle recycling at a central synapse in vivo [PDF]
Frontiers in Synaptic Neuroscience, 2022 Four modes of endocytosis and subsequent synaptic vesicle (SV) recycling have been described at the presynapse to ensure the availability of SVs for synaptic release.
Alp Paksoy +5 more
doaj +2 more sources
Reduced Synaptic Vesicle Recycling during Hypoxia in Cultured Cortical Neurons. [PDF]
Front Cell Neurosci, 2017 Improvement of neuronal recovery in the ischemic penumbra, an area around the core of a brain infarct with some remaining perfusion, has a large potential for the development of therapy against acute ischemic stroke.
Fedorovich S +3 more
europepmc +2 more sources