The role of mitochondrially derived ATP in synaptic vesicle recycling. [PDF]
J Biol Chem, 2015 Background: The ATP requirements of synaptic vesicle release are poorly understood. Results: Mitochondrially derived ATP supports the function of boutons with and without mitochondria.
Pathak D +9 more
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Ethanol Mediated Inhibition of Synaptic Vesicle Recycling at Amygdala Glutamate Synapses Is Dependent upon Munc13-2. [PDF]
Front Neurosci, 2017 Chronic exposure to alcohol produces adaptations within the basolateral amygdala (BLA) that are associated with the development of anxiety-like behaviors during withdrawal.
Gioia DA, Alexander N, McCool BA.
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Endogenous Leucine-Rich Repeat Kinase 2 Slows Synaptic Vesicle Recycling in Striatal Neurons. [PDF]
Front Synaptic Neurosci, 2017 Dominant mutations in leucine-rich repeat kinase 2 (LRRK2) produce the most common inherited form of Parkinson’s disease (PD) but the function of LRRK2 remains poorly understood.
Maas JW, Yang J, Edwards RH.
europepmc +2 more sources
SNARE Regulatory Proteins in Synaptic Vesicle Fusion and Recycling
Frontiers in Molecular Neuroscience, 2021 Membrane fusion is a universal feature of eukaryotic protein trafficking and is mediated by the soluble N-ethylmaleimide sensitive factor attachment protein receptor (SNARE) family.
Chad W. Sauvola +2 more
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Spontaneous Vesicle Recycling in the Synaptic Bouton [PDF]
Frontiers in Cellular Neuroscience, 2014 The trigger for synaptic vesicle exocytosis is Ca2+, which enters the synaptic bouton following action potential stimulation. However, spontaneous release of neurotransmitter also occurs in the absence of stimulation in virtually all synaptic boutons. It
Sven eTruckenbrodt +4 more
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Botulinum Neurotoxins Can Enter Cultured Neurons Independent of Synaptic Vesicle Recycling. [PDF]
PLoS One, 2015 Botulinum neurotoxins (BoNTs) are the causative agent of the severe and long-lasting disease botulism. At least seven different serotypes of BoNTs (denoted A-G) have been described.
Pellett S +3 more
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Concurrent imaging of synaptic vesicle recycling and calcium dynamics. [PDF]
Frontiers in Molecular Neuroscience, 2011 Synaptic transmission involves the calcium-dependent release of neurotransmitter from synaptic vesicles. Genetically encoded optical probes emitting different wavelengths of fluorescent light in response to neuronal activity offer a powerful approach to
Haiyan eLi +12 more
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Activity-dependent facilitation of Synaptojanin and synaptic vesicle recycling by the Minibrain kinase. [PDF]
Nat Commun, 2014 Phosphorylation has emerged as a crucial regulatory mechanism in the nervous system to integrate the dynamic signalling required for proper synaptic development, function and plasticity, particularly during changes in neuronal activity.
Chen CK +5 more
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Synaptic Vesicle-Recycling Machinery Components as Potential Therapeutic Targets. [PDF]
Pharmacol Rev, 2017 Li YC, Kavalali ET.
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Botulinum neurotoxin Light Chain/A1 uses fast synaptic vesicle cycling to cleave plasma membrane bound SNAP-25 [PDF]
Communications BiologyBotulinum neurotoxins (BoNT) are the most potent protein toxins for humans, yet how BoNT-Light Chain/A1 (LC/A1) journeys to cleave intracellular SNAP-25 is understudied.
Alexander Gardner +4 more
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