Results 81 to 90 of about 44,470 (243)

Circadian regulation of developmental synaptogenesis via the hypocretinergic system

, 2023
The circadian clock orchestrates a wide variety of physiological and behavioral processes, enabling animals to adapt to daily environmental changes, particularly the day-night cycle.
Ying Li, Xiao-Lan Peng, Guang Li, Taole Liu, Bing Xu, Yu Zhang, Fu-Ning Li, Jun Yan, Han Wang, Xu-Fei Du, Jiu-Lin Du   +10 more
core   +1 more source

Characterization of dermatan sulfate and chondroitin sulfate profiles during brain regeneration in Styela plicata

The FEBS Journal, EarlyView.
Adult ascidians are capable of regenerating their entire brains following injury, and glycosaminoglycans have been shown to either promote or inhibit neuritogenesis. In this study, dermatan 2,6‐disulfate (D2,6S) was identified as the predominant complex carbohydrate in the ascidian brain.
Taynan Motta Portal, Samara de Oliveira Pimentel, Bruno da Costa Rodrigues, Mauro Sérgio Gonçalves Pavão, Rodrigo Nunes da Fonseca, Cintia Monteiro de Barros   +5 more
wiley   +1 more source

Thrombospondin-4 and excitatory synaptogenesis promote spinal sensitization after painful mechanical joint injury [PDF]

, 2015
Facet joint injury induces persistent pain that may be maintained by structural plasticity in the spinal cord. Astrocyte-derived thrombospondins, especially thrombospondin-4 (TSP4), have been implicated in synaptogenesis and spinal sensitization in ...
Dong, Ling, Zaucke, Frank, Crosby, Nathan D, Kras, Jeffrey V, Winkelstein, Beth A, Luo, Z David   +5 more
core   +1 more source

Editorial Perspective: Expanding the search for environmental exposures related to children's development

Journal of Child Psychology and Psychiatry, EarlyView.
In the fields of child psychology and psychiatry, countless environmental factors have been identified as correlates of children's health and development, yet each of these generally accounts for a small proportion of variance. The unaccounted‐for variation in a model may be due to measurement error, random variation, model misspecifications or ...
Mark Wade, Maya Mammon
wiley   +1 more source

Orchestrated molecular changes of proliferative, migratory‐fibrillar, synaptic, and postmigratory compartments align with precocious cortex‐type specification in the early human pallium

Journal of Anatomy, EarlyView.
Early human cortical development is organized by transient cellular compartments that define cortical types before mature layers form. Analysis of the human fetal pallium (7.5–15 PCW) shows distinct spatiotemporal trajectories for the archicortex, mesocortex, and neocortex, with delayed but accelerated differentiation in allocortical regions.
Janja Kopić, Fran Božić, Alisa Junaković Munjas, Željka Krsnik, Ivica Kostović   +4 more
wiley   +1 more source

Neuromuscular synaptogenesis in wild-type and mutant zebrafish [PDF]

, 2005
Genetic screens for synaptogenesis mutants have been performed in many organisms, but few if any have simultaneously screened for defects in pre- and postsynaptic specializations.
Dosch, Roland, Wagner, Daniel, Gibbs, Sarah M., Panzer, Jessica A., Balice-Gordon, Rita J., Mullins, Mary C., Granato, Michael   +6 more
core   +1 more source

A posttranslational proteomic survey of a single anatomically preserved human 20‐week postconception brain

Journal of Anatomy, EarlyView.
A well‐preserved 20 post‐conception week human brain was obtained and finely dissected into 18 anatomically distinct regions, including the pia mater. Each region underwent in‐depth proteomic analysis, encompassing both total protein content and post‐translational modifications.
S. Bandiera, H. Bogetofte, P. Jensen, R. Hussain, S. A. Nischal, L. Rihova, G. J. Clowry, M. R. Larsen, Z. Molnár, B. C. Carlyle   +9 more
wiley   +1 more source

Immune proteomic associations with indices of cortical development in 5‐year‐old children

Journal of Anatomy, EarlyView.
Typically developing 5‐year‐old children (n = 101–126) from the FinnBrain Birth Cohort Study, Finland, underwent both targeted serum immune proteomics and magnetic resonance brain imaging. Multiple inflammatory markers, from one cluster of co‐expressed immune proteins, were negatively associated with indices of cortical development, including thickness,
Aaron Barron, Aylin Rosberg, Jetro J. Tuulari, Minna Lukkarinen, Harri Merisaari, Eero Silver, Venla Kumpulainen, Anni Copeland, Ekaterina Saukko, Alex M. Dickens, Matej Oresic, Tuulia Hyötylainen, Linnea Karlsson, Hasse Karlsson, Isabella L. C. Mariani Wigley, Elmo P. Pulli   +15 more
wiley   +1 more source

Leptin–cholesterol crosstalk in pregnancy: Mechanistic implications for placental function and cardiometabolic programming

Experimental Physiology, EarlyView.
Abstract Pregnancy requires the coordinated maternal reorganization of lipid and endocrine pathways to sustain fetal growth and anticipate neonatal nutrition. Leptin, produced by adipose tissue and the placenta, acts as an integrative signal linking maternal energy status with trophoblast function and vascular adaptation, while cholesterol provides ...
Julio Flores, Diego Gumera, Andreina Arias, Cristián A. Amador, María José Yañez   +4 more
wiley   +1 more source

On the Stability of Receptivity-Based Adaptive Synaptogenesis

, 2008
: We investigate the stability properties of the receptivity-based adaptive synaptogenesis process. We show that, following convergence, synaptogenesis enters an oscillatory state unless a switching mechanism is employed for its termination.
Hakan Deliç, William B. Levy
core