CaMKIIalpha interacts with multi-PDZ domain protein MUPP1 in spermatozoa and prevents spontaneous acrosomal exocytosis [PDF]
, 2009 The success of acrosomal exocytosis, a complex process with a variety of inter-related steps, relies on the coordinated interaction of participating signaling molecules.
Ackermann, Frauke +5 more
core +1 more source
Ca2+ sensor synaptotagmin-1 mediates exocytosis in mammalian photoreceptors
eLife, 2019 To encode light-dependent changes in membrane potential, rod and cone photoreceptors utilize synaptic ribbons to sustain continuous exocytosis while making rapid, fine adjustments to release rate.
J. Grassmeyer +6 more
semanticscholar +1 more source
Tyrosine kinase inhibition produces specific alterations in axon guidance in the grasshopper embryo [PDF]
, 1998 Tyrosine kinase signaling pathways are essential for process outgrowth and guidance during nervous system development. We have examined the roles of tyrosine kinase activity in programming growth cone guidance decisions in an intact nervous system in ...
Menon, Kaushiki P., Zinn, Kai
core
PRRT2 Is a Key Component of the Ca2+-Dependent Neurotransmitter Release Machinery
Cell Reports, 2016 Heterozygous mutations in proline-rich transmembrane protein 2 (PRRT2) underlie a group of paroxysmal disorders, including epilepsy, kinesigenic dyskinesia, and migraine.
Pierluigi Valente +18 more
doaj +1 more source
Synaptotagmin I, a molecular target for steroid hormone signaling controlling the maturation of sexual behavior in an insect [PDF]
, 2015 As in vertebrates, the insect steroid hormones, especially 20-hydroxyecdysone (20E), initiate and regulate sexual behavior by acting on the central nervous system.
A. Abrieux +7 more
core +5 more sources
Phosphatidylinositol 4,5 bisphosphate controls the cis and trans interactions of synaptotagmin 1
bioRxiv, 2019 Synaptotagmin 1 acts as the Ca2+-sensor for synchronous neurotransmitter release; however, the mechanism by which it functions is not understood and is presently a topic of considerable interest.
Sarah B. Nyenhuis, A. Thapa, D. Cafiso
semanticscholar +1 more source
Genomic Analysis of Synaptotagmin Genes
Genomics, 2001 I used TBLASTn to probe DNA sequence databases with a consensus peptide sequence corresponding to the most highly conserved region of the rodent synaptotagmin (Syt) gene family, which is within the C2B domain. I found human homologues for all known rodent genes, and found six further human genomic loci which encode potential family members.
openaire +2 more sources
Synaptotagmin 7 confers frequency invariance onto specialized depressing synapses
Nature, 2017 At most synapses in the brain, short-term plasticity dynamically modulates synaptic strength. Rapid frequency-dependent changes in synaptic strength have key roles in sensory adaptation, gain control and many other neural computations.
J. Turecek, Skyler L. Jackman, W. Regehr
semanticscholar +1 more source
Synaptotagmin 4: A New Antiobesity Target? [PDF]
Neuron, 2011 In this issue of Neuron, Zhang et al. show that Synaptotagmin 4 (Syt4) is specifically induced in adult hypothalamic oxytocin neurons by high-fat diet. Evidence is provided to support a critical role for Syt4 in negative regulation of oxytocin release, which in turn is responsible for diet-induced obesity, raising the possibility of using Syt4 as a new
openaire +2 more sources
Wnt signalling tunes neurotransmitter release by directly targeting Synaptotagmin-1 [PDF]
, 2015 The functional assembly of the synaptic release machinery is well understood; however, how signalling factors modulate this process remains unknown. Recent studies suggest that Wnts play a role in presynaptic function. To examine the mechanisms involved,
Anane, Derek +9 more
core +2 more sources