Results 151 to 160 of about 38,926 (261)
Multiple factors maintain assembled trans-SNARE complexes in the presence of NSF and αSNAP
eLife, 2019 Neurotransmitter release requires formation of trans-SNARE complexes between the synaptic vesicle and plasma membranes, which likely underlies synaptic vesicle priming to a release-ready state.
Eric A Prinslow +4 more
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Models of synaptotagmin‐1 to trigger Ca2+‐dependent vesicle fusion
FEBS Letters, 2018 Vesicles in neurons and neuroendocrine cells store neurotransmitters and peptide hormones, which are released by vesicle fusion in response to Ca2+‐evoking stimuli.
Yongsoo Park, Je-Kyung Ryu
semanticscholar +1 more source
The Arabidopsis synaptotagmin SYTA regulates the cell-to-cell movement of diverse plant viruses
Frontiers in Plant Science, 2014 Synaptotagmins are a large gene family in animals that have been extensively characterized due to their role as calcium sensors to regulate synaptic vesicle exocytosis and endocytosis in neurons, and dense core vesicle exocytosis for hormone secretion ...
Asako eUchiyama +5 more
doaj +1 more source
Structural basis for the clamping and Ca2+ activation of SNARE-mediated fusion by synaptotagmin
Nature Communications, 2019 Synapotagmin-1 (Syt1) interacts with both SNARE proteins and lipid membranes to synchronize neurotransmitter release to calcium (Ca2+) influx. Here we report the cryo-electron microscopy structure of the Syt1–SNARE complex on anionic-lipid containing ...
K. Grushin +5 more
semanticscholar +1 more source
Synaptotagmin 7 functions as a Ca2+-sensor for synaptic vesicle replenishment
eLife, 2014 Synaptotagmin (syt) 7 is one of three syt isoforms found in all metazoans; it is ubiquitously expressed, yet its function in neurons remains obscure. Here, we resolved Ca2+-dependent and Ca2+-independent synaptic vesicle (SV) replenishment pathways, and ...
Huisheng Liu +7 more
doaj +1 more source
The high-affinity calcium sensor synaptotagmin-7 serves multiple roles in regulated exocytosis
The Journal of General Physiology, 2018 Synaptotagmin (Syt) proteins comprise a 17-member family, many of which trigger exocytosis in response to calcium. Historically, most studies have focused on the isoform Syt-1, which serves as the primary calcium sensor in synchronous neurotransmitter ...
Daniel D Macdougall +6 more
semanticscholar +1 more source
eLifeSNAP25 is one of three neuronal SNAREs driving synaptic vesicle exocytosis. We studied three mutations in SNAP25 that cause epileptic encephalopathy: V48F, and D166Y in the synaptotagmin-1 (Syt1)-binding interface, and I67N, which destabilizes the SNARE ...
Anna Kádková +8 more
doaj +1 more source
Dissecting the functions of Synaptotagmin-1 and Synaptotagmin-7 in synaptic transmission
, 2023 Die zugrundeliegenden Mechanismen, die die neuronale Kommunikation durch synaptische Übertragung steuern, werden seit Jahrzehnten in zahlreichen Studien untersucht. Die Neurotransmission erfolgt im präsynaptischen Bouton, in dem sich spezialisierte sekretorische Organellen, die synaptischen Vesikel (SVs), befinden.
openaire +2 more sources
In vitro fusion of single synaptic and dense core vesicles reproduces key physiological properties.
, 2019 Regulated exocytosis of synaptic vesicles is substantially faster than of endocrine dense core vesicles despite similar molecular machineries. The reasons for this difference are unknown and could be due to different regulatory proteins, different ...
Castle, J. +10 more
core +1 more source
The Extended Synaptotagmins of Physcomitrium patens
PlantsMembrane contact sites (MCSs) between the endoplasmic reticulum and the plasma membrane enable the transport of lipids without membrane fusion. Extended Synaptotagmins (ESYTs) act at MCSs, functioning as tethers between two membrane compartments. In plants, ESYTs have been mainly investigated in A.
Alexander Kaier, Maria Ntefidou
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