Results 1 to 10 of about 13,854 (115)

Biodiversity-Driven Screening of Amphibian Skin Secretions for Inflammatory Modulation in Joint Diseases [PDF]

Toxins
This study explores the direct effects of amphibian skin secretions on human cells involved in joint diseases, aiming to identify species with potential for inflammatory modulation.
Douglas Souza Oliveira, César Alexandre, Miryam Paola Alvarez-Flores, Isadora Maria Villas-Boas, Hugo Vigerelli, Isabel de Fátima Correia Batista, Michelle Cristiane Bufalo, Nancy Starobinas, Flávio Lichtenstein, Rafael Marques-Porto, Marcus Buri, Viviane Portas-Lopes, Pedro Luiz Mailho-Fontana, Marta Maria Antoniazzi, Denise Vilarinho Tambourgi, Ana Marisa Chudzinski-Tavassi, Catarina Teixeira, Carlos Jared, Olga Martinez Ibañez   +18 more
doaj   +2 more sources

Emerging Role of TRP Channels in Osteoarthritis Pathogenesis [PDF]

Cells
Osteoarthritis (OA) is a degenerative joint disease characterized by cartilage degradation, synovial inflammation, osteophyte formation, joint space narrowing, and persistent pain.
Shivmurat Yadav, Jyoti Yadav, Mary Beth Humphrey   +2 more
doaj   +2 more sources

IFNγ production during cell interactions distinguishes localized from diffuse pigmented villonodular synovitis and rheumatoid arthritis [PDF]

Arthritis Research & Therapy
Background Pigmented villonodular synovitis (PVNS) is a rare articular disease characterized by aggressive synovial proliferation, with localized or diffuse forms.
Mélissa Noack, Pierre Miossec
doaj   +2 more sources

A Matrigel-Free 3D Chondrocytic Spheroid Model for Rheumatoid Arthritis-Associated Synoviocytes Invasion Studies [PDF]

Journal of Inflammation Research
Yingjie Zhao,1,2,* Xuezhi Yang,3,* Feng Yao,1,2,* Ziwei Ouyang,2 Weirong Hu,2 Lin Li,4 Juan Cheng,5 Ke Wang,1,2 Jie Ding,2 Liang Zheng,1,2 Biao Qu,1,2 Cheng Sun,2 Shufang Li,1 Chen Jiang,2 Yanan Chen,2 Renpeng Zhou,1,2 Wei Hu1,2 1Department ...
Zhao Y, Yang X, Yao F, Ouyang Z, Hu W, Li L, Cheng J, Wang K, Ding J, Zheng L, Qu B, Sun C, Li S, Jiang C, Chen Y, Zhou R, Hu W   +16 more
doaj   +2 more sources

Nanomaterial-Based Drug Delivery Systems Targeting Functional Cells for Osteoarthritis Treatment: Mechanisms, Challenges and Future Prospects [PDF]

International Journal of Nanomedicine
Hui Kong,1,2 Qijun He,2 Juanjuan Han,2 Xin-An Zhang1,2 1College of Exercise and Health, Shanghai University of Sport, Shanghai, People’s Republic of China; 2College of Exercise and Health, Shenyang Sport University, Shenyang, People’s Republic of ...
Kong H, He Q, Han J, Zhang XA
doaj   +2 more sources

The use of animal models in rheumatoid arthritis research [PDF]

Journal of Yeungnam Medical Science, 2023
The pathological hallmark of rheumatoid arthritis (RA) is a synovial pannus that comprises proliferating and invasive fibroblast-like synoviocytes, infiltrating inflammatory cells, and an associated neoangiogenic response.
Jin-Sun Kong, Gi Heon Jeong, Seung-Ah Yoo   +2 more
doaj   +1 more source

β Boswellic Acid Blocks Articular Innate Immune Responses: An In Silico and In Vitro Approach to Traditional Medicine

Antioxidants, 2023
Osteoarthritis (OA) is hallmarked as a silent progressive rheumatic disease of the whole joint. The accumulation of inflammatory and catabolic factors such as IL6, TNFα, and COX2 drives the OA pathophysiology into cartilage degradation, synovia ...
Eloi Franco-Trepat, Ana Alonso-Pérez, María Guillán-Fresco, Miriam López-Fagúndez, Andrés Pazos-Pérez, Antía Crespo-Golmar, Susana Belén Bravo, Verónica López-López, Alberto Jorge-Mora, José P. Cerón-Carrasco, Ana Lois Iglesias, Rodolfo Gómez   +11 more
doaj   +1 more source

Pro Nerve Growth Factor and Its Receptor p75NTR Activate Inflammatory Responses in Synovial Fibroblasts: A Novel Targetable Mechanism in Arthritis

Frontiers in Immunology, 2022
We have recently provided new evidence for a role of p75NTR receptor and its preferential ligand proNGF in amplifying inflammatory responses in synovial mononuclear cells of chronic arthritis patients.
Luciapia Farina, Gaetana Minnone, Stefano Alivernini, Ivan Caiello, Lucy MacDonald, Marzia Soligo, Luigi Manni, Barbara Tolusso, Simona Coppola, Erika Zara, Libenzio Adrian Conti, Angela Aquilani, Silvia Magni-Manzoni, Mariola Kurowska-Stolarska, Elisa Gremese, Fabrizio De Benedetti, Fabrizio De Benedetti, Luisa Bracci-Laudiero, Luisa Bracci-Laudiero   +18 more
doaj   +1 more source

Signalling and putative therapeutic molecules on the regulation of synoviocyte signalling in rheumatoid arthritis

Bone & Joint Research, 2021
Rheumatoid arthritis (RA) is an autoimmune disease characterized by symmetrical and chronic polyarthritis. Fibroblast-like synoviocytes are mainly involved in joint inflammation and cartilage and bone destruction by inflammatory cytokines and matrix ...
Minjeong Ji, Hee Jung Ryu, Jeong Hee Hong   +2 more
doaj   +1 more source

Osteoarthritis In Vitro Models: Applications and Implications in Development of Intra-Articular Drug Delivery Systems

Pharmaceutics, 2021
Osteoarthritis (OA) is a complex multi-target disease with an unmet medical need for the development of therapies that slow and potentially revert disease progression.
Carlota Salgado, Olivier Jordan, Eric Allémann   +2 more
doaj   +1 more source