Results 21 to 30 of about 13,926 (184)

Insulin Exacerbates Inflammation in Fibroblast-Like Synoviocytes [PDF]

Inflammation, 2020
Abstract Osteoarthritis (OA) is considered the most frequent degenerative disease and is characterized by cartilage degradation and synovial inflammation. Fibroblast-like synoviocytes (FLSs) are vital to synovial inflammation in OA. Type 2 diabetes mellitus (T2DM) is characterized by insulin resistance and hyperinsulinemia (HINS) and has been ...
Li Qiao, Yi Li, Shui Sun
openaire   +2 more sources

Simvastatin Induces Apoptosis of Fibroblast-Like Synoviocytes [PDF]

The Open Rheumatology Journal, 2009
Background: Statins (3-Hydroxy-3-methylglutaryl-CoA reductase inhibitors) exert favorable effects on lipoprotein metabolism, but appeared to possess anti-inflammatory properties among others, as suggested by their ability to inhibit collagen-induced arthritis in mice.
Litinsky, Ira, Golan, Itshak, Yaron, Michael, Yaron, Ilana, Caspi, Dan, Elkayam, Ori   +5 more
openaire   +2 more sources

Reduction of expression of IL‐18, IL‐1β genes in the articular joint by sumac fruit extract (Rhus coriaria L.)

Molecular Genetics & Genomic Medicine, 2019
Background Osteoarthritis is the most common malignant disease in the world. The disease is caused by changes in the metabolism, the structure and function of multiple joints, and joint tissues.
Amin Momeni, Hossein Maghsoodi, Sadegh Rezapour, Mostafa Shiravand, Mahnaz Mardani   +4 more
doaj   +1 more source

Monoclonal expansion of synoviocytes in rheumatoid arthritis [PDF]

Arthritis & Rheumatism, 1998
To examine whether synoviocytes from patients with rheumatoid arthritis (RA) have a stronger growth ability than those from patients with osteoarthritis (OA), and to determine whether these synoviocytes clonally expand in situ.Synovial tissues from 13 RA patients and 4 OA patients were cultured, and their ability to form colonies in soft agarose was ...
F, Imamura, H, Aono, T, Hasunuma, T, Sumida, H, Tateishi, S, Maruo, K, Nishioka   +6 more
openaire   +2 more sources

Fibrochondrogenic potential of synoviocytes from osteoarthritic and normal joints cultured as tensioned bioscaffolds for meniscal tissue engineering in dogs [PDF]

PeerJ, 2014
Meniscal tears are a common cause of stifle lameness in dogs. Use of autologous synoviocytes from the affected stifle is an attractive cell source for tissue engineering replacement fibrocartilage. However, the diseased state of these cells may impede in
Jennifer J. Warnock, Gerd Bobe, Katja F. Duesterdieck-Zellmer   +2 more
doaj   +2 more sources

Angiopoietin-Like Protein 2 Induces Synovial Inflammation in the Facet Joint Leading to Degenerative Changes via Interleukin-6 Secretion [PDF]

Asian Spine Journal, 2019
Study Design Experimental human study. Purpose To determine whether angiopoietin-like protein 2 (ANGPTL2) is highly expressed in the hyperplastic facet joint (FJ) synovium and whether it activates interleukin-6 (IL-6) secretion in FJ synoviocytes ...
Kazuki Sugimoto, Takayuki Nakamura, Takuya Tokunaga, Yusuke Uehara, Tatsuya Okada, Takuya Taniwaki, Toru Fujimoto, Yuichi Oike, Eiichi Nakamura   +8 more
doaj   +1 more source

Regulatory T cells provide chondroprotection through increased TIMP1, IL-10 and IL-4, but cannot mitigate the catabolic effects of IL-1β and IL-6 in a tri-culture model of osteoarthritis

Osteoarthritis and Cartilage Open, 2021
Objective: To gain insight into Treg interactions with synovial tissues in early OA, an equine tri-culture model of OA was used to test the hypothesis that Tregs, in the absence of T Helper 17 ​cells, are sufficient to resolve inflammation elicited by IL-
Laura E. Keller, Elia D. Tait Wojno, Laila Begum, Lisa A. Fortier   +3 more
doaj   +1 more source

Epigenetic analysis in rheumatoid arthritis synoviocytes

Experimental & Molecular Medicine, 2019
Rheumatoid arthritis (RA) is a complex chronic systematic disease with progressive destruction of the joints by invasive synoviocytes. To characterize the key regulators involved in the development of RA, we obtained multilayer epigenomics data including DNA methylation by whole-genome bisulfite sequencing, miRNA profiles, genetic variations by whole ...
Seokjin Ham, Jae-Bum Bae, Suman Lee, Bong-Jo Kim, Bok-Ghee Han, Seung-Ki Kwok, Tae-Young Roh   +6 more
openaire   +4 more sources

Systems-biology analysis of rheumatoid arthritis fibroblast-like synoviocytes implicates cell line-specific transcription factor function

Nature Communications, 2022
Fibroblast-like synoviocytes (FLS) are used as a model of rheumatoid arthritis synoviocytes, although cell lines derived from individual patients can have heterogeneous biology.
Richard I. Ainsworth, Deepa Hammaker, Gyrid Nygaard, Cecilia Ansalone, Camilla Machado, Kai Zhang, Lina Zheng, Lucy Carrillo, Andre Wildberg, Amanda Kuhs, Mattias N. D. Svensson, David L. Boyle, Gary S. Firestein, Wei Wang   +13 more
doaj   +1 more source

Interactive Cytokine Regulation of Synoviocyte Lubricant Secretion [PDF]

Tissue Engineering Part A, 2010
Cytokine regulation of synovial fluid (SF) lubricants, hyaluronan (HA), and proteoglycan 4 (PRG4) is important in health, injury, and disease of synovial joints, and may also provide powerful regulation of lubricant secretion in bioreactors for articulating tissues.
Megan E, Blewis, Brian J, Lao, Barbara L, Schumacher, William D, Bugbee, Robert L, Sah, Gary S, Firestein   +5 more
openaire   +2 more sources