Results 31 to 40 of about 13,926 (184)

Advancing Early Detection of Osteoarthritis Through Biomarker Profiling and Predictive Modelling: A Review

Biologics
Osteoarthritis (OA) is a multifactorial chronic musculoskeletal disorder characterised by cartilage degradation, synovial inflammation, and subchondral bone remodelling. Conventional diagnostic modalities, including radiographic imaging and symptom-based
Laura Jane Coleman, John L. Byrne, Stuart Edwards, Rosemary O’Hara   +3 more
doaj   +1 more source

SIRT1 is transcriptionally repressed by YY1 and suppresses ferroptosis in rheumatoid arthritis

Advances in Rheumatology, 2023
Highlights 1. Combining SIRT1 with synoviocytes ferroptosis in rheumatoid arthritis for the first time. 2. The transcription factor YY1 combined to the SIRT1 promoter in synovial cells and inhibited its expression and functional roles. 3.
Yuwei Zhan, Zhou Yang, Feng Zhan, Yanyan Huang, Shudian Lin   +4 more
doaj   +1 more source

Interleukin-25 Produced by Synoviocytes Has Anti-inflammatory Effects by Acting As a Receptor Antagonist for Interleukin-17A Function

Frontiers in Immunology, 2017
The production and function of cytokines are highly regulated. One mechanism is the balance between pro- and anti-inflammatory cytokines. As interleukin (IL)-17A and IL-25 share the IL-17RA receptor chain, we hypothesize that IL-25 acts as an IL-17A ...
Fabien Lavocat, Ndiémé Ndongo-Thiam, Pierre Miossec   +2 more
doaj   +1 more source

Epigenetic Alterations in Rheumatoid Arthritis Fibroblast-Like Synoviocytes [PDF]

Epigenomics, 2017
Rheumatoid arthritis is an immune-mediated disease that primarily affects diarthrodial joints. Susceptibility and severity of this disease are influenced by nongenetic factors, such as environmental stress, suggesting an important role of epigenetic changes.
Doody, Karen M, Bottini, Nunzio, Firestein, Gary S   +2 more
openaire   +4 more sources

Th17 and Th1 Lymphocytes in Oligoarticular Juvenile Idiopathic Arthritis

Frontiers in Immunology, 2019
In the last years much attention has focused on the Th17 and Th1 phenotypes and on their pathogenic role in juvenile idiopathic arthritis, investigating how the cytokines produced by T helper cells act on resident cells on the synovia and which signal ...
Laura Maggi, Alessio Mazzoni, Rolando Cimaz, Francesco Liotta, Francesco Annunziato, Lorenzo Cosmi   +5 more
doaj   +1 more source

Synoviocytes and skin fibroblasts show opposite effects on IL-23 production and IL-23 receptor expression during cell interactions with immune cells

Arthritis Research & Therapy, 2022
Background The IL-23/IL-17 axis is involved in inflammatory diseases including arthritis and psoriasis. However, the response to IL-23 or IL-17 inhibitors is different depending on the disease.
Mélissa Noack, Pierre Miossec
doaj   +1 more source

Altered phospholipids in human rheumatoid synoviocytes. [PDF]

Annals of the Rheumatic Diseases, 1978
A specific cytochemical reaction for freely available phospholipids has shown a raised concentration of such phospholipids in the lining cells of human synovial membranes removed from rheumatoid joints. Quantitative measurement, by microdensitometry, of the amount of reaction-product per cell showed that the rheumatoid synoviocytes contained almost ...
B, Henderson, L, Bitensky, J, Chayen
openaire   +2 more sources

An overview of carbonic anhydrases and membrane channels of synoviocytes in inflamed joints

Journal of Enzyme Inhibition and Medicinal Chemistry, 2019
The highly aggressive fibroblast-like synoviocytes (FLSs) are inflammatory mediators involved in synovial joint destruction. Membrane channels and transporters are essential components of the cell migration apparatus and are involved in various cellular ...
Min Jeong Ji, Jeong Hee Hong
doaj   +1 more source

Pyroptosis for osteoarthritis treatment: insights into cellular and molecular interactions inflammatory

Frontiers in Immunology
Osteoarthritis (OA) is a widely prevalent chronic degenerative disease often associated with significant pain and disability. It is characterized by the deterioration of cartilage and the extracellular matrix (ECM), synovial inflammation, and subchondral
Minghui Lin, Cunxin Zhang, Haiming Li, Kang Li, Shuao Gou, Xiao He, Xiao He, Chaoliang Lv, Kai Gao   +8 more
doaj   +1 more source

The autocrine role of proteoglycan-4 (PRG4) in modulating osteoarthritic synoviocyte proliferation and expression of matrix degrading enzymes

Arthritis Research & Therapy, 2017
Background Lubricin/proteoglycan 4 (PRG4) is a mucinous glycoprotein secreted by synovial fibroblasts and superficial zone chondrocytes. Recently, we showed that recombinant human PRG4 (rhPRG4) is a putative ligand for CD44 receptor.
Ali Alquraini, Maha Jamal, Ling Zhang, Tannin Schmidt, Gregory D. Jay, Khaled A. Elsaid   +5 more
doaj   +1 more source