Results 241 to 250 of about 15,323,666 (293)

Single‐Cell Transcriptomic Profiling Identifies B Cell‐Intrinsic Dysregulation of Sphingolipid Biosynthesis and Could Be Improved by Inhibiting UGCG in Primary Immune Thrombocytopenia

Advanced Science, EarlyView.
This study generates the single‐cell atlas of pathogenic B‐cell subset Bc‐5 in ITP. It identifies RUNX3 as a key survival regulator and uncovers sphingolipid‐driven metabolic reprogramming, validating UGCG inhibition as a therapeutic candidate and building a valuable resource for ITP mechanistic and therapeutic exploration.
Dongmei Luo, Yanxia Zhan, Lili Ji, Pengcheng Xu, Pu Chen, Hao Pang, Yunan Ling, Fanli Hua, Xibing Zhuang, Hao Chen, Yunfeng Cheng   +10 more
wiley   +1 more source

Development and validation of a novel T cell exhaustion-related signature to predict prognosis in patients with breast cancer. [PDF]

Discov Oncol
Guo L, Chen X, Zhou F.
europepmc   +1 more source

Optimized Land–Water Management Expands Afforestation Potential Under Land and Human Water‐Use Constraints

Advanced Science, EarlyView.
Human water demand constrains China's feasible afforestation potential more strongly than is commonly recognized, and future climate change further intensifies this limitation. Integrating land‐use optimization with water‐saving measures substantially expands feasible afforestation area and associated carbon sinks, revealing a practical pathway to ...
Binbin Huang, Fei Lu, Yuebo Su, Xuming Wang, Hua Zheng, Zhiyun Ouyang   +5 more
wiley   +1 more source

Altered OXPHOS potential in ascites immune cells is linked to CD4 T-cell exhaustion and a higher risk of spontaneous bacterial peritonitis in cirrhosis. [PDF]

Front Immunol
Cosgun HT, Kumar P, Zhang IW, Hammerich L, Sudheer V, Pavlidis C, Wang J, Schwarz H, Tacke F, Canbay A, Engelmann C.   +10 more
europepmc   +1 more source

Proteasome-guided haem signalling axis contributes to T cell exhaustion. [PDF]

Nature
Xu Y, Shangguan Y, Chuang YM, Chang TH, Liu W, Peng JJ, Garnica J, Xie L, Hsueh PC, Lin MC, Wang YH, Hajdu KL, Wu Y, Akrami M, Wang C, Kohl A, Zippelius A, Qi W, Wang M, Budiarto BR, Chen SY, Xiao Z, Vardaka P, Roychoudhuri R, Bai Z, Fan R, Carmona S, Yu YR, Scheiermann C, Wang J, Ho PC.   +30 more
europepmc   +1 more source

Traditional Chinese Medicine in Chronic Hepatitis B: Integrating Antiviral Effects and Immune Modulation in the Context of T Cell Exhaustion. [PDF]

Drug Des Devel Ther
Zhao X, Mei C, Cheng FE, Li S, Zheng S, Qi W, Ye Y.   +6 more
europepmc   +1 more source

T Cell Exhaustion in Hepatocellular Carcinoma: A Substantial Barrier in Immunotherapy. [PDF]

J Cell Mol Med
Nouri K, Asadollahei N, Haghir-Sharif-Zamini Y, Seydi H, Salehi M, Mesdaghi M, Najimi M, Vosough M.   +7 more
europepmc   +1 more source

Cytotoxic T-cell exhaustion analyses by in situ single-cell immunofluorescence in relation to colorectal cancer patient age, tissue bacteria and mortality. [PDF]

BMJ Oncol
Nakazawa N, Matsuda K, Ugai S, Miyahara S, Kondo A, Higashioka M, Zhong Y, Mannucci A, Cavestro GM, Chan AT, Nowak JA, Song M, Saeki H, Giannakis M, Väyrynen JP, Ugai T, Ogino S.   +16 more
europepmc   +1 more source