Results 261 to 270 of about 15,323,666 (293)

CD8+ T cell exhaustion

Seminars in Immunopathology, 2019
CD8+ T cells are important for the protective immunity against intracellular pathogens and tumor. In the case of chronic infection or cancer, CD8+ T cells are exposed to persistent antigen and/or inflammatory signals. This excessive amount of signals often leads CD8+ T cells to gradual deterioration of T cell function, a state called "exhaustion ...
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Restimulation by macrophages exhausts T cells

Immunity
Inhibiting T cell exhaustion is an attractive cancer immunotherapy strategy. In this issue of Immunity, Waibl Polania et al. examine the microenvironmental signals regulating terminal T cell exhaustion and find that antigen presentation by tumor-associated macrophages, not tumor cells, drives terminal T cell exhaustion in glioblastoma.
Fernando Fernández-García, Barbara B. Maier   +1 more
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T-cell exhaustion in HIV infection

Current HIV/AIDS Reports, 2008
Generation of memory T cells, which mediate immunity against microbes and cancers, relies, for optimal activity, on the interactions of multiple cell types that are highly regulated through the expression of soluble factors and negative and positive receptors.
Mohamed, El-Far, Rabih, Halwani, Elias, Said, Lydie, Trautmann, Mehrnoosh, Doroudchi, Loury, Janbazian, Simone, Fonseca, Julien, van Grevenynghe, Bader, Yassine-Diab, Rafick-Pierre, Sékaly, Elias K, Haddad   +10 more
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Overcoming CAR T cell exhaustion

Nature Reviews Immunology, 2019
Overexpression of JUN by CAR T cells renders them resistant to exhaustion and improves tumour control in mouse models, including of solid tumours and of tumours with low levels of antigen expression.
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Stress to exhaustion: Proteotoxicity in T cells

Molecular Cell
In a recent Nature paper, Yi et al.1 uncover that a noncanonical proteotoxic stress response (PSR) in exhausted T cells (Tex), termed "Tex-PSR," drives T cell exhaustion. This response is characterized by sustained global protein synthesis, accumulation of protein aggregate, and selective upregulation of chaperone proteins.
Ting, Zhang, Chen, Dong
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Regulators of CD8+ T cell exhaustion

Nature Reviews Immunology
T cell exhaustion is an adaptive and distinct cell fate that emerges in response to persistent antigen stimulation, primarily in chronic infections and cancer. It is characterized by a progressive loss of effector functions and sustained expression of multiple inhibitory receptors.
Qinli Sun, Chen Dong
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T cell exhaustion in human cancers

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
T cell exhaustion refers to a progressive state in which T cells become functionally impaired due to sustained antigenic stimulation, which is characterized by increased expression of immune inhibitory receptors, but weakened effector functions, reduced self-renewal capacity, altered epigenetics, transcriptional programme and metabolism.
Kuan, Kang, Xin, Lin, Pan, Chen, Huai, Liu, Feng, Liu, Wei, Xiong, Guiyuan, Li, Mei, Yi, Xiayu, Li, Hui, Wang, Bo, Xiang   +10 more
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T-cell exhaustion in multiple myeloma

Expert Review of Hematology
Chimeric Antigen Receptor (CAR) T-cells and Bispecific Antibodies (BsAb) are the leading platforms for redirecting the immune system against cells expressing the specific antigen, revolutionizing the treatment of hematological malignancies, including multiple myeloma (MM).
Krzysztof Żyłka, Tadeusz Kubicki, Lidia Gil, Dominik Dytfeld   +3 more
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Bypassing T cell 'exhaustion'

Nature Immunology, 2013
The hypoxia-inducible factor (HIF) pathway controls diverse aspects of the immunological response. Enhanced HIF activity is able to extend and potentiate the effector response of CD8+ T cells against chronic infections and tumor growth.
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Clinical Implications of T Cell Exhaustion for Cancer Immunotherapy

Nature Reviews Clinical Oncology, 2022
Jedd D. Wolchok, Christopher A. Klebanoff, Andrew Chow   +2 more
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