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Defining ‘T Cell Exhaustion’ [PDF]
Nature Reviews Immunology, 2019 'T cell exhaustion' is a broad term that has been used to describe the response of T cells to chronic antigen stimulation, first in the setting of chronic viral infection but more recently in response to tumours. Understanding the features of and pathways to exhaustion has crucial implications for the success of checkpoint blockade and adoptive T cell ...
Pamela L. Schwartzberg, William Haining
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Genome-Wide CRISPR Screens of T Cell Exhaustion Identify Chromatin Remodeling Factors That Limit T Cell Persistence [PDF]
Cancer Cell, 2022 T cell exhaustion limits antitumor immunity, but the molecular determinants of this process remain poorly understood. Using a chronic stimulation assay, we performed genome-wide CRISPR-Cas9 screens to systematically discover regulators of T cell ...
Kathryn E Yost +2 more
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Science Signaling, 2023
Catecholamines associated with stress promote T cell exhaustion through the β 1 -adrenergic receptor.
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Catecholamines associated with stress promote T cell exhaustion through the β 1 -adrenergic receptor.
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Epigenetic regulation of T cell exhaustion
Nature Immunology, 2022Chronic antigen stimulation during viral infections and cancer can lead to T cell exhaustion, which is characterized by reduced effector function and proliferation, and the expression of inhibitory immune checkpoint receptors. Recent studies have demonstrated that T cell exhaustion results in wholescale epigenetic remodeling that confers phenotypic ...
Julia A. Belk +2 more
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Charting the Roadmap of T Cell Exhaustion
Immunity, 2020Exposure to chronic infection or malignant tumors triggers the differentiation of functionally impaired, so-called exhausted T cells. In this issue of Immunity, Beltra et al. reveal a multi-step developmental process that defines how T cells transition from proliferating progenitors into terminally differentiated exhausted T cells.
Talyn, Chu, Dietmar, Zehn
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Transcriptional regulation and T cell exhaustion
Current Opinion in HIV and AIDS, 2014This review highlights the control of transcriptional networks, including induction of inhibitory receptors, by T cell-specific transcription factors in exhausted T cells that accumulate in chronic viral infections including HIV.Transcriptional profiling has established distinct molecular phenotypes for exhausted CD4 and CD8 T cells in chronic viral ...
Matthew H, Collins, Andrew J, Henderson
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Nature Immunology, 2011
T cell exhaustion is a state of T cell dysfunction that arises during many chronic infections and cancer. It is defined by poor effector function, sustained expression of inhibitory receptors and a transcriptional state distinct from that of functional effector or memory T cells. Exhaustion prevents optimal control of infection and tumors.
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T cell exhaustion is a state of T cell dysfunction that arises during many chronic infections and cancer. It is defined by poor effector function, sustained expression of inhibitory receptors and a transcriptional state distinct from that of functional effector or memory T cells. Exhaustion prevents optimal control of infection and tumors.
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Reversal of exhaustion in engineered T cells
Science, 2021Antitumor activity of exhausted engineered T cells is improved with pulsatile ...
Maksim, Mamonkin, Malcolm K, Brenner
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Blood, 2013
In this issue of Blood, Riches and colleagues provide an in-depth characterization of T cells and particularly CD8+ T cells from patients with chronic lymphocytic leukemia (CLL). They demonstrate that CD8+ T cells exhibit defects in proliferation, cytotoxicity, and increased expression of inhibitory receptors and thus exhibit features of T-cell ...
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In this issue of Blood, Riches and colleagues provide an in-depth characterization of T cells and particularly CD8+ T cells from patients with chronic lymphocytic leukemia (CLL). They demonstrate that CD8+ T cells exhibit defects in proliferation, cytotoxicity, and increased expression of inhibitory receptors and thus exhibit features of T-cell ...
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Rather active for ‘exhausted’ T cells
Nature Reviews Immunology, 2021A recent preprint describes that human exhausted T cells turn on an active migratory programme in tumours that could reflect an unexplored function.
Julie M, Mazet, Anne, Chauveau
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