Results 51 to 60 of about 15,323,666 (293)

Early Acquisition of CD8+ T Cell Exhaustion State Is Regulated by Ezh2 [PDF]

, 2022
During infection with an acute microbial infection, responding CD8+ T cells give rise to effector cells that provide acute host defense and memory cells that provide sustained protection.
Quezada, Lauren Kainani
core   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Disturbed mitochondrial dynamics in CD8(+)TILs reinforce T cell exhaustion [PDF]

, 2020
[[abstract]]Ho and colleagues report that mitochondrial dysfunction and impaired mitophagy triggered by the tumor microenvironment lead to subsequent epigenetic changes and cause permanent T cell exhaustion and dysfunction.
Yu, YR;Imrichova, H;Wang, HP;Chao, T;Xiao, ZT;Gao, M;Rincon-Restrepo, M;Franco, F;Genolet, R;Cheng, WC;Jandus, C;Coukos, G;Jiang, YF;Locasale, JW;Zippelius, A;Liu, PS;Tang, L;Bock, C;Vannini, N;Ho, PC
core   +2 more sources

Exhaustion of CAR T cells: potential causes and solutions

Journal of Translational Medicine, 2022
Chimeric antigen receptor (CAR) T cell therapy has attracted attention for its promising therapeutic effects on hematological malignancies. However, there are problems such as relapse during long-term follow-up and limited effect on solid tumors with ...
Taku Kouro, Hidetomo Himuro, Tetsuro Sasada   +2 more
doaj   +1 more source

Exhaust the exhausters: Targeting regulatory T cells in the tumor microenvironment

Frontiers in Immunology, 2022
The concept of cancer immunotherapy has gained immense momentum over the recent years. The advancements in checkpoint blockade have led to a notable progress in treating a plethora of cancer types. However, these approaches also appear to have stalled due to factors such as individuals’ genetic make-up, resistant tumor sub-types and immune related ...
Bayley R. McRitchie, Bayley R. McRitchie, Billur Akkaya, Billur Akkaya, Billur Akkaya   +4 more
openaire   +3 more sources

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

CD147 regulates CD8+ T cell cytotoxic activity by facilitating phosphorylation and subsequent recruitment of proximal TCR signaling kinases

iScience
Summary: CD8+ T cells are the primary cytotoxic cells within the tumor microenvironment, where T cell receptor (TCR) signaling drives their activation and effector functions.
Taiyu Shu, Dan Wang, Hao Wang, Jie Zou, Heyao Qin, Xue Liang, Hongyong Cui, Qian He, Yuxi Zhang, Jianli Jiang   +9 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

MAF drives CD8(+) T-cell exhaustion.

, 2015
The molecular regulation of tumor induced T-cell exhaustion remains poorly characterized. Recently, we compared the transcriptome of "exhausted" CD8(+) T cells infiltrating melanomas to those of naive and acutely stimulated CD8(+) T cells.
Verdeil, G., Verdeil G
core   +1 more source