Results 41 to 50 of about 15,323,666 (293)
Annual Review of ImmunologyT cell responses must be balanced to ensure adequate protection against malignant transformation and an array of pathogens while also limiting damage to healthy cells and preventing autoimmunity. T cell exhaustion serves as a regulatory mechanism to limit the activity and effector function of T cells undergoing chronic antigen stimulation.
Andrew, Baessler, Dario A A, Vignali
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T cell anergy versus T cell exhaustion.
, 2014 T cell anergy versus T cell exhaustion.
Mireille Laforge (349277) +6 more
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Research on strategies to inhibit CAR-T cell exhaustion [PDF]
Xin yixueImmunotherapy has achieved good efficacy in clinical anti-tumor therapy， especially chimeric antigen receptor T cell （CAR-T cell） therapy， as an emerging tumor immunotherapy， has achieved breakthrough efficacy in the clinical treatment of hematologic ...
FU Qiongyu, HAO Xinbao, TAO Shi
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T-cell exhaustion in the tumor microenvironment [PDF]
, 2016 T-cell exhaustion was originally identified during chronic infection in mice, and was subsequently observed in humans with cancer. The exhausted T cells in the tumor microenvironment show overexpressed inhibitory receptors, decreased effector cytokine ...
Jiang, Y, Zhu, B, Li, Y
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T-cell exhaustion in the tumor microenvironment [PDF]
Cell Death & Disease, 2015 AbstractT-cell exhaustion was originally identified during chronic infection in mice, and was subsequently observed in humans with cancer. The exhausted T cells in the tumor microenvironment show overexpressed inhibitory receptors, decreased effector cytokine production and cytolytic activity, leading to the failure of cancer elimination.
Jiang, Y, Li, Y, Zhu, B
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Tireless surveillance by exhausted T cells
Journal of Clinical Investigation, 2021 T cell exhaustion is an evocative concept that results in attenuated function in the face of chronic antigen exposure and is critical to avoid immunopathology. However, tumors often exploit this dampened T cell function to escape the antitumor immune response. In this issue of the JCI, You et al.
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Memory T cell, exhaustion, and tumor immunity
Immunological Medicine, 2020 CD8+T cells are important in protective immunity against intracellular pathogens and tumors. In chronic infections or cancer, CD8+T cells are constantly exposed to antigens and inflammatory signals.
Makoto Ando +4 more
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The epigenetic landscape of T cell exhaustion [PDF]
Science, 2016 Epigenetic profiling suggests that exhausted T cells are a distinct cell linage.
Sen, Debattama R +18 more
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Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Genome Medicine, 2020 Background T cells exhibit heterogeneous functional states in the tumor microenvironment. Immune checkpoint inhibitors (ICIs) can reinvigorate only the stem cell-like progenitor exhausted T cells, which suggests that inhibiting the exhaustion progress ...
Kyungsoo Kim +11 more
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