Results 31 to 40 of about 15,323,666 (293)

Dual function of the NK cell receptor 2B4 (CD244) in the regulation of HCV-specific CD8+ T cells [PDF]

, 2011
The outcome of viral infections is dependent on the function of CD8+ T cells which are tightly regulated by costimulatory molecules. The NK cell receptor 2B4 (CD244) is a transmembrane protein belonging to the Ig superfamily which can also be expressed ...
Lunemann, Sebastian, Bektas, Hueseyin, Heiner Wedemeyer, Wedemeyer Heiner, Suneetha, Pothakamuri Venkata, Grabowski, Jan, Michael Peter Manns, Markus Cornberg, Sarrazin, Christoph, Julia Dietz, Hueseyin Bektas, Christoph Sarrazin, Helfritz Fabian, Schlaphoff, Verena, Lunemann Sebastian, Fabian Helfritz, Suneetha Pothakamuri Venkata, Dietz, Julia, Jaroszewicz, Jerzy, Wedemeyer, Heiner, Bektas Hueseyin, Sebastian Lunemann, Pothakamuri Venkata Suneetha, Sarrazin Christoph, Manns Michael Peter, Jaroszewicz Jerzy, Jerzy Jaroszewicz, Helfritz, Fabian Arnold, Cornberg, Markus, Jan Grabowski, Schlaphoff Verena, Dietz Julia, Manns, Michael P., Verena Schlaphoff, Grabowski Jan, Cornberg Markus   +35 more
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Illuminating T-cell Exhaustion [PDF]

Cancer Discovery, 2016
Abstract Two studies have illuminated some of the molecular underpinnings of T-cell exhaustion. The first pinpoints the subset of exhausted T cells that revive upon PD-1 blockade. The second describes key metabolic deficiencies—restricted glucose uptake and mitochondrial dysfunction—that drive T cells to exhaustion.
openaire   +2 more sources

CD39 Expression Identifies Terminally Exhausted CD8+ T Cells. [PDF]

PLoS Pathogens, 2015
Exhausted T cells express multiple co-inhibitory molecules that impair their function and limit immunity to chronic viral infection. Defining novel markers of exhaustion is important both for identifying and potentially reversing T cell exhaustion ...
Prakash K Gupta, Jernej Godec, David Wolski, Emily Adland, Kathleen Yates, Kristen E Pauken, Cormac Cosgrove, Carola Ledderose, Wolfgang G Junger, Simon C Robson, E John Wherry, Galit Alter, Philip J R Goulder, Paul Klenerman, Arlene H Sharpe, Georg M Lauer, W Nicholas Haining   +16 more
doaj   +1 more source

Stepwise activities of mSWI/SNF family chromatin remodeling complexes direct T cell activation and exhaustion

, 2023
Highly coordinated changes in gene expression underlie T cell activation and exhaustion. However, the mechanisms by which such programs are regulated and how these may be targeted for therapeutic benefit remain poorly understood. Here, we comprehensively
Perna, Fabiana, Cervantes, Kasey S., Ntatsoulis, Konstantinos, Lee, Soobeom, Cesarano, Annamaria, Comstock, Dawn E., Rodriguez Hernaez, Javier, Hockemeyer, Kathryn, Kadoch, Cigall, Hixon, Kimberlee A., Tsirigos, Aristotelis, Witkowski, Matthew T., Qi, Jun, Haining, W. Nicholas, Chen, Xufeng, Hinkley, Madeline M., Battistello, Elena, Collings, Clayton K., Aifantis, Iannis, Cigall Kadoch, Xufeng Chen, Kimberlee A. Hixon, Kasey S. Cervantes, Soobeom Lee, Dawn E. Comstock, Matthew T. Witkowski, Javier Rodriguez Hernaez, Clayton K. Collings, W. Nicholas Haining, Elena Battistello, Madeline M. Hinkley, Kathryn Hockemeyer, Konstantinos Ntatsoulis, Annamaria Cesarano, Fabiana Perna, Iannis Aifantis, Jun Qi, Aristotelis Tsirigos   +37 more
core   +1 more source

SnapShot: T Cell Exhaustion

Cell, 2015
Exhaustion is a state of T cell differentiation common during chronic infection and cancer that results in T cell dysfunction. Exhausted T cells (TEX) progressively lose effector functions and develop defects in memory T cell properties due to exposure to persistent antigen and inflammation.
Pauken, Kristen E., Wherry, E. John
openaire   +2 more sources

Malaria drives T cells to exhaustion [PDF]

Frontiers in Microbiology, 2014
Malaria is a significant global burden but after >30 years of effort there is no vaccine on the market. While the complex life cycle of the parasite presents several challenges, many years of research have also identified several mechanisms of immune evasion by Plasmodium spp. Recent research on malaria, has investigated the programmed cell death-1 (PD-
Michelle N Wykes, Joshua M Horne-Debets, Joshua M Horne-Debets, Chiuan-Yee eLeow, Deshapriya eKarunarathne   +4 more
openaire   +6 more sources

Aberrant T-cell exhaustion in severe combined immunodeficiency survivors with poor T-cell reconstitution after transplantation [PDF]

, 2022
BACKGROUND: Severe combined immunodeficiency (SCID) comprises rare inherited disorders of immunity that require definitive treatment through hematopoietic cell transplantation (HCT) or gene therapy for survival.
Pulsipher, Michael, Chandra, Sharat, Buckley, Rebecca, Griffith, Linda, Boufaied, Ines, Cowan, Morton, Labrosse, Roxane, Dvorak, Christopher, Kapoor, Neena, Parrott, Roberta, Bourbonnais, Sara, Chan, Wendy, Decaluwe, Hélène, Barreiro, Luis, Logan, Brent, Cuvelier, Geoffrey, Heimall, Jennifer, Goldman, Fred, Randolph, Haley, Haddad, Élie, Kohn, Donald, Gona, Saideep, Pai, Sung-Yun, Dávila Saldaña, Blachy, Berthe, Chloé, Puck, Jennifer, Chaudhury, Sonali, OReilly, Richard, Notarangelo, Luigi, Shenoy, Shalini, Kolb, Edward, Eissa, Hesham, Bourdin, Benoîte, Barreiro, Luis B., Logan, Brent R., O’Reilly, Richard, S, Shalini Shenoy, Buckley, Rebecca H., Parrott, Roberta E., Dvorak, Christopher C., et al.,, Goldman, Fred D., Kohn, Donald B., Notarangelo, Luigi D., Cowan, Morton J., Randolph, Haley E., Saldaña, Blachy J. Dávila, Griffith, Linda M., Cuvelier, Geoffrey D.E., Kolb, Edward A., Puck, Jennifer M.   +50 more
core   +1 more source

Mitochondrial dysfunction defines T cell exhaustion [PDF]

Cell Metabolism, 2021
When T cells are exposed to continuous antigen stimulation, they become exhausted. Here, we preview findings from Scharping et al. (2021), who have illuminated the molecular mechanism by which the persistent antigen stimulation and severe hypoxic conditions in the intratumoral environment drive T cell exhaustion, losing their cytotoxic function and ...
Soto-Heredero, Gonzalo, Desdín-Micó, Gabriela, Mittelbrunn, María   +2 more
openaire   +3 more sources

Expression of Programmed Cell Death 1 (PD-1) as a Marker of T-Cell Exhaustion and Its Correlation with Interleukin-10 Serum Level in Patients with COVID-19

, 2021
Coronavirus disease 2019 (COVID-19), which is a major global concern, is characterized by a progressive disease pattern involving diverse host immune responses. Programmed cell death marker-1(PD-1) expression, a critical checkpoint for T cell exhaustion,
Wafaa K. Zaki, Fatma M. Mahmoud, Dalia M. Ibrahim, Amr H. Hamza, Nadia M. ElSheshtawy   +4 more
core   +1 more source

Reprogramming T cell differentiation and exhaustion in CAR-T cell therapy

Journal of Hematology & Oncology, 2023
T cell differentiation is a highly regulated, multi-step process necessary for the progressive establishment of effector functions, immunological memory, and long-term control of pathogens.
Yannick Bulliard, Borje S. Andersson, Mehmet A. Baysal, Jason Damiano, Apostolia M. Tsimberidou   +4 more
doaj   +1 more source