Results 11 to 20 of about 15,323,666 (293)

T‐cell exhaustion in HIV infection [PDF]

Immunological Reviews, 2019
AbstractThe T‐cell response is central in the adaptive immune‐mediated elimination of pathogen‐infected and/or cancer cells. This activated T‐cell response can inflict an overwhelming degree of damage to the targeted cells, which in most instances leads to the control and elimination of foreign invaders.
Craig Fenwick, Victor Joo, Patricia Jacquier, Alessandra Noto, Riddhima Banga, Matthieu Perreau, Giuseppe Pantaleo   +6 more
openaire   +5 more sources

Deletion of SNX9 alleviates CD8 T cell exhaustion for effective cellular cancer immunotherapy

Nature Communications, 2023
The efficacy of T-cell-based cancer immunotherapies can be compromised by T cell exhaustion. Here the authors develop a human ex vivo exhaustion model and, based on a CRISPR-Cas9 screen, identify SNX9 as a regulator of T cell exhaustion, showing that ...
Marcel P. Trefny, Nicole Kirchhammer, Priska Auf der Maur, Marina Natoli, Dominic Schmid, Markus Germann, Laura Fernandez Rodriguez, Petra Herzig, Jonas Lötscher, Maryam Akrami, Jane C. Stinchcombe, Michal A. Stanczak, Andreas Zingg, Melanie Buchi, Julien Roux, Romina Marone, Leyla Don, Didier Lardinois, Mark Wiese, Lukas T. Jeker, Mohamed Bentires-Alj, Jérémie Rossy, Daniela S. Thommen, Gillian M. Griffiths, Heinz Läubli, Christoph Hess, Alfred Zippelius   +26 more
doaj   +2 more sources

T Cell Dysfunction and Exhaustion in Cancer [PDF]

Frontiers in Cell and Developmental Biology, 2020
Tumor immunotherapy is a promising therapeutic strategy for patients with advanced cancers. T cells are key mediators of antitumor function that specifically recognize and react to tumor-expressing antigens and have proven critical for cancer ...
Zhen Zhang, Shasha Liu, Bin Zhang, Liang Qiao, Yi Zhang, Yi Zhang, Yi Zhang, Yi Zhang, Yi Zhang   +8 more
doaj   +3 more sources

T-cell Exhaustion in Organ Transplantation

Transplantation, 2021
Exhaustion of T cells occurs in response to long-term exposure to self and foreign antigens. It limits T cell capacity to proliferate and produce cytokines, leading to an impaired ability to clear chronic infections or eradicate tumors. T-cell exhaustion is associated with a specific transcriptional, epigenetic, and metabolic program and characteristic
Angeletti A., Cantarelli C., Riella L. V., Fribourg M., Cravedi P.   +4 more
openaire   +3 more sources

Inhibitory receptors beyond T cell exhaustion [PDF]

Frontiers in Immunology, 2015
Inhibitory receptors (iRs) are frequently associated with T cell exhaustion. However, the expression of iRs is also dependent on T cell differentiation and activation.
Silvia A Fuertes Marraco, Silvia A Fuertes Marraco, Natalie J Neubert, Natalie J Neubert, Gregory eVerdeil, Gregory eVerdeil, Daniel E Speiser, Daniel E Speiser   +7 more
doaj   +5 more sources

Editorial: T Cell Exhaustion [PDF]

Frontiers in Immunology, 2020
Cristina Bonorino, Cristina Bonorino, Giuliana Mognol   +2 more
doaj   +3 more sources

Single-cell RNA-seq reveals T cell exhaustion and immune response landscape in osteosarcoma [PDF]

Frontiers in Immunology
BackgroundT cell exhaustion in the tumor microenvironment has been demonstrated as a substantial contributor to tumor immunosuppression and progression.
Qizhi Fan, Yiyan Wang, Jun Cheng, Boyu Pan, Xiaofang Zang, Renfeng Liu, Youwen Deng   +6 more
doaj   +2 more sources

Mitochondrial Metabolism in T-Cell Exhaustion

International Journal of Molecular Sciences
T cells play a vital role in resisting pathogen invasion and maintaining immune homeostasis. However, T cells gradually become exhausted under chronic antigenic stimulation, and this exhaustion is closely related to mitochondrial dysfunction in T cells.
Fei Li, Yu Feng, Zesheng Yin, Yahong Wang   +3 more
openaire   +4 more sources

Focus on T cell exhaustion: new advances in traditional Chinese medicine in infection and cancer

Chinese Medicine, 2023
In chronic infections and cancers, T lymphocytes (T cells) are exposed to persistent antigen or inflammatory signals. The condition is often associated with a decline in T-cell function: a state called “exhaustion”. T cell exhaustion is a state of T cell
Shenghao Li, Liyuan Hao, Junli Zhang, Jiali Deng, Xiaoyu Hu   +4 more
doaj   +2 more sources

Unlocking T cell exhaustion: Insights and implications for CAR-T cell therapy

Acta Pharmaceutica Sinica B
Chimeric antigen receptor T (CAR-T) cell therapy as a form of adoptive cell therapy (ACT) has shown significant promise in cancer treatment, demonstrated by the FDA-approved CAR-T cell therapies targeting CD19 or B cell maturation antigen (BCMA) for ...
Dian Xiong, Haijun Yu, Zhi-Jun Sun
doaj   +2 more sources