Results 21 to 30 of about 15,323,666 (293)

Molecular insight into T cell exhaustion in hepatocellular carcinoma

Pharmacological Research
Hepatocellular carcinoma is one of the leading causes of cancer-related mortality globally. The emergence of immunotherapy has been shown to be a promising therapeutic approach for hepatocellular carcinoma in recent years.
Yonghua Zhu, Huabing Tan, Jincheng Wang, Haiwen Zhuang, Huanbin Zhao, Xiaojie Lu   +5 more
doaj   +2 more sources

T cell exhaustion in malignant gliomas

Trends in Cancer, 2023
Despite advances in understanding tumor biology, malignant gliomas remain incurable. While immunotherapy has improved outcomes in other cancer types, comparable efficacy has not yet been demonstrated for primary cancers of the central nervous system (CNS).
Matthew B. Watowich, Mark R. Gilbert, Mioara Larion   +2 more
openaire   +2 more sources

Mathematical deconvolution of CAR T-cell proliferation and exhaustion from real-time killing assay data [PDF]

, 2020
Chimeric antigen receptor (CAR) T-cell therapy has shown promise in the treatment of haematological cancers and is currently being investigated for solid tumours, including high-grade glioma brain tumours.
Brown, Christine E., Yang, Xin, Maestrini, Davide, Rockne, Russell C., Rockne, Russell C, Cho, Heyrim, Adhikarla, Vikram, Abler, Daniel, Wang, Dongrui, Machuca, Vanessa, Frankhouser, David, Barish, Michael, Gutova, Margarita, Sahoo, Prativa, Brown, Christine E, Branciamore, Sergio   +15 more
core   +2 more sources

Killer fatigue: Transition to NK-cell-like phenotype is a signature of CAR-T cell exhaustion [PDF]

, 2021
Exhaustion of chimeric antigen receptor (CAR)-T cells hinders their therapeutic efficacy, especially in treating solid tumors. In this issue of Cell, Good et al.
Chen, Yvonne Y, Hong, Mihe, Mihe Hong, Yvonne Y. Chen   +3 more
core   +1 more source

Chronic type I interferon signaling promotes lipid-peroxidation-driven terminal CD8+ T cell exhaustion and curtails anti-PD-1 efficacy

, 2022
Identifying signals that govern the differentiation of tumor-infiltrating CD8+ T cells (CD8+ TILs) toward exhaustion can improve current therapeutic approaches for cancer.
Yau, SW, Chen, WX, Che, CM, Javed, A, Teo, JMN, Ma, SPN, Huang, YH, Ling, GS, Wong, MYM, Lok, CN   +9 more
core   +1 more source

Schrödinger’s T Cells: Molecular Insights Into Stemness and Exhaustion

Frontiers in Immunology, 2021
T cell stemness and exhaustion coexist as two key contrasting phenomena during chronic antigen stimulation, such as infection, transplant, cancer, and autoimmunity.
Nancy M. Gonzalez, Nancy M. Gonzalez, Dawei Zou, Andy Gu, Wenhao Chen, Wenhao Chen   +5 more
doaj   +1 more source

Combating Chronic T-cell Exhaustion [PDF]

Immunotherapy, 2012
T cells are currently being employed for the treat‐ ment of patients with persistent viral infections or cancer in many immunotherapeutic approaches, including provision of cytokines, therapeutic vaccines or adoptive transfer of virus‐ or tumor‐ specific T cells [1–6].
Megan S, McAfee, Joseph N, Blattman
openaire   +2 more sources

Upregulation of the Tim-3/galectin-9 pathway of T cell exhaustion in chronic hepatitis B virus infection. [PDF]

, 2012
The S-type lectin galectin-9 binds to the negative regulatory molecule Tim-3 on T cells and induces their apoptotic deletion or functional inactivation.
Cheng, Y, Richard Gilson, Singh, HD, Nebbia Gaia, Dusheiko, G., William Rosenberg, Peppa, D, Cheng, Y., Geoffrey Dusheiko, Cheng Yang, Joanne ChinAleong, ChinAleong, J, Patrick Kennedy, Dusheiko Geoffrey, Maini Mala K., Singh Harsimran D., Pooja Khanna, Maini, MK, Nebbia, G., Khanna, P, Gaia Nebbia (125377), Rosenberg, W, Rosenberg William, Rosenberg, W., Schurich, Anna; id_orcid, Gilson, R, ChinAleong Joanne, Mala K. Maini (125417), Patrick Kennedy (125414), Mala K Maini, Harsimran D Singh, Gilson Richard, ChinAleong, J., Gaia Nebbia, Harsimran D. Singh (125388), Nebbia, G, Khanna Pooja, Kennedy, P., Richard Gilson (125405), Schurich, A, Anna Schurich, Joanne ChinAleong (125409), Geoffrey Dusheiko (125400), Kennedy, P, Singh, H.D., Pooja Khanna (125385), William Rosenberg (14858), Khanna, P., Peppa Dimitra, Gilson, R., Kennedy Patrick, Yang Cheng (125394), Dusheiko, G, Dimitra Peppa, Dimitra Peppa (125379), Yang Cheng, Anna Schurich (125382), Maini, M.K., Peppa, D., Schurich Anna   +59 more
core   +1 more source

Bibliometric and visual analyses of trends in the field of T cell exhaustion research: Findings from 2000 to 2022

International Journal of Immunopathology and Pharmacology, 2023
Background T cell exhaustion refers to a state wherein T cells become less functional as a result of their prolonged exposure to cognate antigens. A wealth of T cell exhaustion-focused research has been conducted in recent decades, transforming the ...
Ziling Liu, Huan Wan, Yao Tan, Deshuang Li, Jianguo Huang, Chuanhe Zhang, Fangyuan Liu, Bo Qin   +7 more
doaj   +1 more source

T cell exhaustion in protozoan disease [PDF]

Trends in Parasitology, 2012
Protozoan parasites cause severe morbidity and mortality in humans worldwide, especially in developing countries where access to chemotherapeutic agents is limited. Although parasites initially evoke a robust immune response, subsequent immunity fails to clear infection, ultimately leading to the chronic stage.
Jason P, Gigley, Rajarshi, Bhadra, Magali M, Moretto, Imtiaz A, Khan   +3 more
openaire   +2 more sources