Results 181 to 190 of about 95,123 (301)

T cell development in the chicken [PDF]

, 1994
T. KUBOTA, Chen, Chen-Lo H., Cooper, Max D., M.D. COOPER, Kubota, Takayuki, Göbel, Thomas W. F., T.W.F. GÖBEL, C.H. CHEN   +7 more
core   +1 more source

Autoreactivity vs autoimmunity: characteristics of autoantigen‐specific CD4 T‐cells in rheumatoid arthritis and health.

Arthritis &Rheumatology, Accepted Article.
Background CD4 T cells specific for citrullinated (cit)‐peptides are key players in RA immunopathogenesis. Characterising these cells and identifying features of healthy and RA‐associated autoreactivity will provide valuable insight into disease mechanisms and form the basis of immune state biomarkers to facilitate the next generation of RA treatments.
James A. Stanway, Daniel Peters, Helen Waller, Jeremy Lakey, Henrique De Paula Lemos, Kristian Williams, Abbie Degnan, Julie Diboll, Abdul Mannan Baru, David Tough, Arthur G. Pratt, Catharien M.U. Hilkens, Amy E. Anderson, John D. Isaacs   +13 more
wiley   +1 more source

Editorial: New avenues for the development of advanced immunotherapies: capitalizing on studies of the B and T cell receptor repertoire. [PDF]

Front Immunol
Nicolini F, Naranjo Gomez M, Pelegrin M, De Lucia A, Mazzotti L, Mazza M.   +5 more
europepmc   +1 more source

A current and future perspective on T cell receptor repertoire profiling. [PDF]

Front Genet, 2023
Shen Y, Voigt A, Leng X, Rodriguez AA, Nguyen CQ.   +4 more
europepmc   +1 more source

Integrated Clinical and Proteomic Profiling of CD19 Chimeric Antigen Receptor T Cell Therapy in Progressive Systemic Sclerosis

Arthritis &Rheumatology, EarlyView.
Objective To characterize the clinical, immunologic, and proteomic changes associated with CD19 chimeric antigen receptor T cell therapy in patients with progressive systemic sclerosis (SSc). Methods Patients with progressive SSc received CD19 chimeric antigen receptor (CAR)‐T cell therapy and were observed longitudinally for safety, clinical efficacy,
Chenhan Jia, Wanyi Lin, Zhangyi Zhao, Fenglin Wu, Chaoyu Gu, Yuankai Sun, Zhe Ding, Chang Wei, Xinyu Li, Cuiwei Xie, Peng Xia, Zhen Xia, Xuesong Liu, Shaoying Yang, Chunyan Zhang, Hanlin Yin, Liangjing Lu   +16 more
wiley   +1 more source

Circulating T-cell receptor repertoire and clinicopathological correlations in breast cancer patients: immune repertoire analysis from the VGH-TAYLOR study. [PDF]

Breast Cancer Res
Tseng LM, Huang CC, Chen JL, Tsai YF, Chao TC, Wu WC, Lien PJ, Lin YS, Feng CJ, Chen YJ, Lai JI, Chiu JH, Hsu CY, Liu CY.   +13 more
europepmc   +1 more source

The role of IgM anti‐acetylated protein antibodies and B cells in the origin of anti‐modified protein autoimmunity in rheumatoid arthritis

Arthritis &Rheumatology, Accepted Article.
Objective Rheumatoid arthritis (RA) is characterized by anti‐modified protein antibodies (AMPAs), including anti‐citrullinated (ACPA), anti‐carbamylated (anti‐CarP), and anti‐acetylated (AAPA) protein antibodies. In contrast to other AMPAs, AAPA IgM is found in healthy individuals, raising questions about its role in early immune responses.
Aegli Athanasiadou, Sanne Kroos, Renee van de Wetering, Rian Schopmeijer, Carin van der Keur HLO, Michael Eikmans, Caroline Meijer, Solbritt Rantapää‐Dahlqvist, René E.M. Toes, Linda M. Slot, Diane van der Woude   +10 more
wiley   +1 more source

Large-Scale T-cell Receptor Repertoire Profiling Unveils Tumor-Specific Signals for Diagnosing Indeterminate Pulmonary Nodules. [PDF]

Cancer Res
Luo H, Guo W, Luan X, Yue T, Yu S, Yin X, Zu R, Rao L, Hu B, Liu X, Xiang R, Zhou P, Liu J, Zhang P, Chen Y, Zhang X, Zhou S, Wang J, Li ZC, Qin W, Yang X, Gu J, Guo AY, Xu M, Yi Q, Huang J, Liu J, Wang D, Chen S.   +28 more
europepmc   +1 more source

Immunoinformatics‐Based Design of a Multi‐Epitope Vaccine Targeting a Conserved Copper–Associated Protein in Neisseria gonorrhoeae

Biotechnology and Applied Biochemistry, EarlyView.
ABSTRACT Neisseria gonorrhoeae poses an urgent public health challenge due to rapidly increasing antimicrobial resistance and the absence of an effective vaccine. Targeting conserved bacterial pathways involved in essential physiological processes may provide new opportunities for vaccine antigen discovery.
Sinethemba H. Yakobi, Uchechukwu U. Nwodo   +1 more
wiley   +1 more source

Resistance potential of the HLA-A2-restricted immunodominant SARS-CoV-2-specific CD8⁺ T cell receptor repertoire to antigenic drift. [PDF]

Nat Commun
Malone MJ, Huang C, Zhang Y, Qi Y, Williams L, Su LF, Lou J, Jiang N.   +7 more
europepmc   +1 more source