Results 41 to 50 of about 87,488 (261)

Sunflower centromeres consist of a centromere-specific LINE and a chromosome-specific tandem repeat

Frontiers in Plant Science, 2015
The kinetochore is a protein complex including kinetochore-specific proteins that plays a role in chromatid segregation during mitosis and meiosis. The complex associates with centromeric DNA sequences that are usually species-specific. In plant species,
Kiyotaka eNagaki, Keisuke eTanaka, Naoki eYamaji, Hisato eKobayashi, Minoru eMurata   +4 more
doaj   +1 more source

Straglr: discovering and genotyping tandem repeat expansions using whole genome long-read sequences

Genome Biology, 2021
Tandem repeat (TR) expansion is the underlying cause of over 40 neurological disorders. Long-read sequencing offers an exciting avenue over conventional technologies for detecting TR expansions.
Readman Chiu, Indhu-Shree Rajan-Babu, Jan M. Friedman, Inanc Birol   +3 more
doaj   +1 more source

Evolution of Tandem Repeats Is Mirroring Post-polyploid Cladogenesis in Heliophila (Brassicaceae)

Frontiers in Plant Science, 2021
The unigeneric tribe Heliophileae encompassing more than 100 Heliophila species is morphologically the most diverse Brassicaceae lineage. The tribe is endemic to southern Africa, confined chiefly to the southwestern South Africa, home of two biodiversity
Mert Dogan, Mert Dogan, Milan Pouch, Milan Pouch, Terezie Mandáková, Terezie Mandáková, Petra Hloušková, Xinyi Guo, Pieter Winter, Zuzana Chumová, Adriaan Van Niekerk, Klaus Mummenhoff, Ihsan A. Al-Shehbaz, Ladislav Mucina, Ladislav Mucina, Martin A. Lysak, Martin A. Lysak   +16 more
doaj   +1 more source

Detecting Expansions of Tandem Repeats in Cohorts Sequenced with Short-Read Sequencing Data [PDF]

The American Journal of Human Genetics, 2018
Repeat expansions cause more than 30 inherited disorders, predominantly neurogenetic. These can present with overlapping clinical phenotypes, making molecular diagnosis challenging. Single-gene or small-panel PCR-based methods can help to identify the precise genetic cause, but they can be slow and costly and often yield no result.
Tankard, R.M., Bennett, M.F., Degorski, P., Delatycki, M.B., Lockhart, P.J., Bahlo, M.   +5 more
openaire   +2 more sources

Tandem repeats of the 5′ flanking region of human MUC5AC have a role as a novel enhancer in MUC5AC gene expression

Biochemistry and Biophysics Reports, 2019
MUC5AC is a well-known gastric differentiation marker, which has been frequently used for the classification of stomach cancer. However, the molecular mechanism of regulation of MUC5AC expression remains to be elucidated.
Natsuko Kageyama-Yahara, Nobutake Yamamichi, Yu Takahashi, Chihiro Takeuchi, Yuta Matsumoto, Yoshiki Sakaguchi, Kazuhiko Koike   +6 more
doaj   +1 more source

Identification of tandem repeat families from long-read sequences of Humulus lupulus.

PLoS ONE, 2020
Hop (Humulus lupulus L.) is known for its use as a bittering agent in beer and has a rich history of cultivation, beginning in Europe and now spanning the globe.
Katherine A Easterling, Nicholi J Pitra, Taylan B Morcol, Jenna R Aquino, Lauren G Lopes, Kristin C Bussey, Paul D Matthews, Hank W Bass   +7 more
doaj   +1 more source

TRiCoLOR: tandem repeat profiling using whole-genome long-read sequencing data [PDF]

GigaScience, 2020
Abstract Background Tandem repeat sequences are widespread in the human genome, and their expansions cause multiple repeat-mediated disorders. Genome-wide discovery approaches are needed to fully elucidate their roles in health and disease, but resolving tandem repeat variation accurately remains a ...
Davide Bolognini, Alberto Magi, Vladimir Benes, Jan O Korbel, Tobias Rausch   +4 more
openaire   +2 more sources

Differentially Amplified Repetitive Sequences Among Aegilops tauschii Subspecies and Genotypes

Frontiers in Plant Science, 2021
Genomic repetitive sequences commonly show species-specific sequence type, abundance, and distribution patterns, however, their intraspecific characteristics have been poorly described.
Rahman Ebrahimzadegan, Fatemeh Orooji, Pengtao Ma, Ghader Mirzaghaderi   +3 more
doaj   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source