Results 21 to 30 of about 198,272 (298)

NanoSatellite: accurate characterization of expanded tandem repeat length and sequence through whole genome long-read sequencing on PromethION

Genome Biology, 2019
Technological limitations have hindered the large-scale genetic investigation of tandem repeats in disease. We show that long-read sequencing with a single Oxford Nanopore Technologies PromethION flow cell per individual achieves 30× human genome ...
Arne De Roeck, Wouter De Coster, Liene Bossaerts, Rita Cacace, Tim De Pooter, Jasper Van Dongen, Svenn D’Hert, Peter De Rijk, Mojca Strazisar, Christine Van Broeckhoven, Kristel Sleegers   +10 more
doaj   +1 more source

Evolutionary Study of Protein Short Tandem Repeats in Protein Families

Biomolecules, 2023
Tandem repeats in proteins are patterns of residues repeated directly adjacent to each other. The evolution of these repeats can be assessed by using groups of homologous sequences, which can help pointing to events of unit duplication or deletion.
Pablo Mier, Miguel A. Andrade-Navarro
doaj   +1 more source

Counting short tandem repeats [PDF]

Nature Methods, 2020
A method using CRISPR–Cas technology, nanopore sequencing and bioinformatics enables quantification of short tandem repeats with high accuracy.
openaire   +2 more sources

Specific tandem repeats are sufficient for paramutation-induced trans-generational silencing. [PDF]

PLoS Genetics, 2013
Paramutation is a well-studied epigenetic phenomenon in which trans communication between two different alleles leads to meiotically heritable transcriptional silencing of one of the alleles.
Christiane L Belele, Lyudmila Sidorenko, Maike Stam, Rechien Bader, Mario A Arteaga-Vazquez, Vicki L Chandler   +5 more
doaj   +1 more source

Ligand selectivity in stabilising tandem parallel folded G-quadruplex motifs in human telomeric DNA sequences [PDF]

, 2014
Biophysical studies of ligand interactions with three human telomeric repeat sequences (d(AGGG(TTAGGG)n, n = 3, 7 and 11)) show that an oxazole-based ‘click’ ligand, which induces parallel folded quadruplexes, preferentially stabilises longer telomeric ...
Alex R. O. Cousins, Balkwill, Bejugam, Biffi, Brooks, De Armond, De Cian, Dougal Ritson, Feng, Fernando, Fletcher, Garner, Grand, Haider, Huppert, John E. Moses, Kim, Kumari, Lingner, Lipps, Malcolm F. G. Stevens, Mark S. Searle, Mergny, Moorhouse, Moorhouse, Nakamura, Neidle, Pallavi Sharma, Petraccone, Petraccone, Randall, Renciuk, Ritson, Searle, Siddiqui-Jain, Todd, Vorlickova, Wang, Xu   +38 more
core   +1 more source

FISH landmarks reflecting meiotic recombination and structural alterations of chromosomes in wheat (Triticum aestivum L.)

BMC Plant Biology, 2021
Background DNA sequence composition affects meiotic recombination. However, the correlation between tandem repeat composition and meiotic recombination in common wheat (Triticum aestivum L.) is unclear.
Yang Zou, Linrong Wan, Jie Luo, Zongxiang Tang, Shulan Fu   +4 more
doaj   +1 more source

A Census of Tandemly Repeated Polymorphic Loci in Genic Regions Through the Comparative Integration of Human Genome Assemblies

Frontiers in Genetics, 2018
Polymorphic Tandem Repeat (PTR) is a common form of polymorphism in the human genome. A PTR consists in a variation found in an individual (or in a population) of the number of repeating units of a Tandem Repeat (TR) locus of the genome with respect to ...
Loredana M. Genovese, Filippo Geraci, Lucia Corrado, Eleonora Mangano, Romina D'Aurizio, Roberta Bordoni, Marco Severgnini, Giovanni Manzini, Giovanni Manzini, Gianluca De Bellis, Sandra D'Alfonso, Marco Pellegrini   +11 more
doaj   +1 more source

Condensin Promotes Position Effects within Tandem DNA Repeats via the RITS Complex

Cell Reports, 2016
Summary: Tandem repetitive DNA is highly abundant in eukaryotic genomes and contributes to transcription control and genome stability. However, how the individual sequences within tandem repeats behave remains largely unknown.
Haijin He, Shu Zhang, Danni Wang, Andreas Hochwagen, Fei Li   +4 more
doaj   +1 more source

Copy number evolution in simple and complex tandem repeats across the C57BL/6 and C57BL/10 inbred mouse lines

G3: Genes, Genomes, Genetics, 2021
Simple sequence tandem repeats are among the most rapidly evolving compartments of the genome. Some repeat expansions are associated with mammalian disease or meiotic segregation distortion, yet the rates of copy number change across generations are not ...
Jullien M Flynn, Emily J Brown, Andrew G Clark   +2 more
doaj   +1 more source

Tools for the identification of variable and potentially variable tandem repeats

BMC Genomics, 2006
Background Tandem repeat arrays showing variation between sequences within a population, between strains or across species may have functional effects. The increasing availability of genomic sequence data makes routine description of observed variation ...
Shields Denis C, O'Dushlaine Colm T
doaj   +1 more source