Results 71 to 80 of about 183,884 (308)

Hydrazonyl Radical-Participated Tandem Reaction: A Strategy for the Synthesis of Pyrazoline-Functionalized Oxindoles

, 2015
An efficient and practical tandem cyclization/addition/cyclization strategy is developed for the initial generated hydrazonyl radicals derived from the oxidation of β,γ-unsaturated hydrazones.
Pan-Pan Jia (1457575), Xiao-Yong Duan (1457578), Xiu-Long Yang (1457581), Man Zhang (466843), Bing Han (38992)   +4 more
core   +2 more sources

Tandem CAR-T cells targeting mesothelin and MUC16 overcome tumor heterogeneity by targeting one antigen at a time

Journal for ImmunoTherapy of Cancer
Background Tumor heterogeneity and antigen escape are mechanisms of resistance to chimeric antigen receptor (CAR)-T cell therapy, especially in solid tumors.
Eugene Kim, Marcela V Maus, Alexander Armstrong, Amanda A Bouffard, Mark B Leick, Christopher Kelly, Giulia Escobar, Filippo Birocchi, Diego Salas-Benito, Tamina Kienka, Sangwoo Park, Cassidy E Ho, Aiyana L Parker, Jessica A Frank, Kiana Graham, Sadie Goncalves, Bo Rueda, Trisha R Berger   +17 more
doaj   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

A Quantitative Shape Control Strategy for Hot Tandem Mill

, 2011
For modern hot tandem mill, various shape control means are equipped, so its shape control ability is strong. How to reasonably distribute every stand’s shape control ability is a difficult problem. If the distribution scheme is unreasonable, every stand’
Hong Min Liu, Dong Cheng Wang
core   +1 more source

Simulation study of reducing reflection losses in all-perovskite tandem solar cells through dual serrated structure

Frontiers of Optoelectronics
The power conversion efficiency of all-perovskite tandem solar cells is predominantly constrained by optical absorption losses, especially reflection losses.
Wenjiang Ye, Aoyue Chen, Ping Fu, Jiang Tang, Chao Chen   +4 more
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Perbedaan Pengaruh Tandem Gait Exercise Dan Ankle Strategy Exercise Terhadap Keseimbangan Pada Lanjut Usia [PDF]

, 2018
Latar Belakang:Seorang lansia akan membawa perubahan yang menyeluruh pada fisiknya yang berkaitan dengan menurunnya kemampuan jaringann tubuh terutama pada fungsi fisiologi dalam sistem muskuloskeletal dan sistem neurologis. Perubahan
Sari, Ririn Puspita
core  

Palladium-catalyzed tandem aza-Heck reaction of alkene-tethered oxime esters with cyclopropanols

Green Synthesis and Catalysis
Aza-Heck cyclization of alkene-tethered oxime esters has received considerable attention as an effective strategy for synthesizing 1-pyrroline derivatives. However, the achievement of tandem aza-Heck reaction with alkyl electrophiles remains a challenge.
Kangning Cao, Shutao Qi, Jianhui Li, Wenshao Ye, Junfeng Yang, Junliang Zhang, Fener Chen   +6 more
doaj   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Surface chemical polishing and passivation minimize non-radiative recombination for all-perovskite tandem solar cells

Nature Communications
All-perovskite tandem solar cells have shown great promise in breaking the Shockley–Queisser limit of single-junction solar cells. However, the efficiency improvement of all-perovskite tandem solar cells is largely hindered by the surface defects induced
Yongyan Pan, Jianan Wang, Zhenxing Sun, Jiaqi Zhang, Zheng Zhou, Chenyang Shi, Sanwan Liu, Fumeng Ren, Rui Chen, Yong Cai, Huande Sun, Bin Liu, Zhongyong Zhang, Zhengjing Zhao, Zihe Cai, Xiaojun Qin, Zhiguo Zhao, Yitong Ji, Neng Li, Wenchao Huang, Zonghao Liu, Wei Chen   +21 more
doaj   +1 more source