Results 81 to 90 of about 183,884 (308)
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
, 2022 A novel protocol of rhodium-catalyzed tandem C–H annulation of aldehyde and aniline with diazonaphthalen-1(2H)-one via transient directing group strategy and sequential nucleophilic substitution has been demonstrated in moderate to excellent yields. This
Jin-Ping Zhang (237904) +5 more
core +1 more source
Tandem polymer solar cells: simulation and optimization through a multiscale scheme
Beilstein Journal of Nanotechnology, 2017 In this paper, polymer solar cells with a tandem structure were investigated and optimized using a multiscale simulation scheme. In the proposed multiscale simulation, multiple aspects – optical calculation, mesoscale simulation, device scale simulation ...
Fanan Wei +4 more
doaj +1 more source
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
TanDEM-X Performance Optimization
, 2007 TanDEM-X (TerraSAR-X add-on for Digital Elevation Measurement) is a space borne earth observation mission with the goal of generating a global Digital Elevation Model (DEM) with an unprecedented accuracy corresponding to the HRTI-3 specifications. TanDEM-
Huber, Sigurd +3 more
core
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Nano-Micro LettersHighlights Integrating perovskite solar cells onto irregular rough CuIn(Ga)Se2 (CIGS) surfaces remains a challenge; new strategy was explored to develop monolithic perovskite/CIGS tandem solar cell by manipulating the crystallization of perovskite ...
Cong Geng +9 more
doaj +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
The TanDEM-X Mission Design and Data Acquisition Plan
, 2006 The TanDEM-X mission comprises two fully active synthetic aperture radar Xband satellites, operating three years as a joint mission. The primary goal of this mission is the derivation of a high-precision global DEM according to HRTI level 3 quality. Also
Wickler, Martin +7 more
core