Results 61 to 70 of about 797 (157)

CRISPRa Lipid Nanocomplex‐Mediated Mt3 Targeting Enhances Astrocytic Endocytosis of Amyloid‐β in an Alzheimer's Disease Mouse Model

open access: yesAdvanced Science, Volume 13, Issue 4, 19 January 2026.
GeTe exhibits intrinsically high carrier concentrations that limit its thermoelectric performance. Herein, CuAgSe alloying synergistically tunes the band structure, induces band flattening and valence‐band convergence, promotes Cu‐ion delocalization, and generates multiscale hierarchical structures to suppress phonon transport.
Junhang Park   +13 more
wiley   +1 more source

Activation of the cGAS/STING Pathway Contributes to Neuroinflammation in Diabetes‐Associated Cognitive Decline

open access: yesMedicine Bulletin, Volume 1, Issue 2, Page 200-212, December 2025.
ABSTRACT Background and Aim Diabetes‐associated cognitive decline (DACD) is a prevalent central nervous system disorder that lacks effective therapies and remains poorly understood in terms of its underlying mechanisms. The activation of cGAS, a crucial cytosolic nucleic acid sensor for double‐stranded DNA, initiates the STING signaling pathway, which ...
Hai‐Jun Zhang   +6 more
wiley   +1 more source

Emerging Perspectives on Gonadotropin Regulation in Vertebrates Revealed by the Discovery of FSH‐RH in Teleosts

open access: yesBioEssays, Volume 47, Issue 11, November 2025.
Regarding pituitary gonadotropin regulation, recent studies have shown that in mammals, FSH and LH are regulated by a single GnRH (solo GnRH model), whereas in teleosts, they are regulated by CCK (FSH‐RH) and GnRH (LH‐RH), respectively (dual GnRH model).
Daichi Kayo   +3 more
wiley   +1 more source

Hypothalamic Astrocytes Exhibit Glycolytic Features Making Them Prone for Glucose Sensing

open access: yesGlia, Volume 73, Issue 11, Page 2253-2272, November 2025.
Main Points Hypothalamic astrocytes versus cortical astrocytes: are more glycolytic due to high Pkm2, Glut1 and Mct4 expression do not exhibit glutamate‐induced glycolysis detect glucose concentration variations via an AMPK sensor with altered lactate production.
Sarah Geller   +11 more
wiley   +1 more source

LOCALIZATION OF TIGHT JUNCTIONS BETWEEN TANYCYTE-LIKE CELLS OF THE SULCUS MEDIANUS ORGANUM IN RAT BRAIN

open access: yesThe Iraqi Journal of Medical Sciences, 2017
Background: Tanycytes are highly specialized ependymal cells (ECs) that line the regions of circumventricular organs (CVOs) where the blood-brain barrier is absent.
Fadhil H. Ahmed   +3 more
doaj   +6 more sources

Impact of Growth Hormone on Microglial and Astrocytic Function

open access: yesJournal of Integrative Neuroscience
The role of growth hormone (GH) in the central nervous system (CNS) involves neuroprotection, neuroregeneration, formation of axonal projections, control of cognition, and regulation of metabolism.
Mariana R. Tavares   +3 more
doaj   +1 more source

Glial Endozepines Inhibit Feeding-Related Autonomic Functions by Acting at the Brainstem Level

open access: yesFrontiers in Neuroscience, 2017
Endozepines are endogenous ligands for the benzodiazepine receptors and also target a still unidentified GPCR. The endozepine octadecaneuropeptide (ODN), an endoproteolytic processing product of the diazepam-binding inhibitor (DBI) was recently shown to ...
Florent Guillebaud   +11 more
doaj   +1 more source

Connexin-43 Gap Junctions Are Responsible for the Hypothalamic Tanycyte-Coupled Network

open access: yesFrontiers in Cellular Neuroscience, 2018
Tanycytes are hypothalamic radial glia-like cells that form the basal wall of the third ventricle (3V) where they sense glucose and modulate neighboring neuronal activity to control feeding behavior.
Antonia Recabal   +11 more
doaj   +1 more source

Recurrent Cerebral Astroblastoma with Aggressive Histology: An Uncommon Case

open access: yesIndian Journal of Neurosurgery, 2017
Astroblastomas are uncommon tumors of uncertain histogenesis. Recently tanycyte is postulated to be the cell of origin. These occur predominantly in the cerebral hemisphere of young adults and children. Astroblastoma constitutes approximately 0.45 to 2.8%
Sumit Bansal   +3 more
doaj   +1 more source

Hypothalamic tanycytes - masters and servants of metabolic, neuroendocrine and neurogenic functions

open access: yesFrontiers in Neuroscience, 2015
There is a resurgent interest in tanycytes, a radial glial-like cell population occupying the floor and ventro-lateral walls of the third ventricle (3V).
Timothy eGoodman   +1 more
doaj   +1 more source

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