Results 61 to 70 of about 373 (115)

Annexin A1 couples tanycyte nutrient sensing to microglial function and thermoregulation

Tanycytes are specialized glial cells lining the third ventricle that sense metabolic cues and contribute to hypothalamic regulation of energy balance. Although their role in nutrient sensing is well established, their contribution to hypothalamic immune
Irina Kolotuev, Emmanuel Di Valentin, David Lopez-Rodriguez, Chaitanya Gavani, Judith Estrada-Meza, Hannah Dulex, Andrea Messina, Rafik Dali, Léane Allaz, Fanny Langlet, Virginie Mansuy-Aubert, Antoine Rohrbach, Tamara Deglise, Xavier Berney   +13 more
core   +1 more source

3D reconstruction of electron microscopy image showed immunogold labels of vGluT2 associated with large dense-core vesicles in a neuroterminal of a representative middle-aged VEH treated rat.

, 2015
(A) Lower magnification electron microscopy image was taken from the portal capillary zone of the lateral median eminence. A vGluT2 immunolabeled neuroterminal (Term, pseudocolored in light orange) was separated from the portal capillary area ...
Deena M. Walker (137174), Penny D. Riha (751266), Zengrong Sun (751265), Weiling Yin (751264), Kelsey S. Bezner (751267), John M. Mendenhall (394558), Andrea C. Gore (137187)   +6 more
core   +1 more source

Acceleration of Lactate Uptake and Utilization Contributes to Neuroprotective Action of FGF21 Involved in Naturally Aging Mice

Aging Cell, Volume 25, Issue 3, March 2026.
The left panel shows cerebral lactate homeostasis in young mice. The middle panel displays accelerated ANLS rates due to FGF21 secretion in aging mice. The right panel demonstrates that lactate uptake and usage inhibition contribute to lactate extracellular accumulation, followed by HCA1‐mediated learning and memory decline in mice.
Keru Ji, Hongde Wei, Ruguang Wang, Yutong Wu, Chen Li, Hongchang Gao, Liangcai Zhao   +6 more
wiley   +1 more source

The role of fibroblast growth factors in cell and cancer metabolism

FEBS Letters, Volume 600, Issue 2, Page 140-163, January 2026.
Fibroblast growth factor (FGF) signaling regulates crucial signaling cascades that promote cell proliferation, survival, and metabolism. Therefore, FGFs and their receptors are often dysregulated in human diseases, including cancer, to sustain proliferation and rewire metabolism.
Jessica Price, Chiara Francavilla
wiley   +1 more source

Growth Differentiation Factor 15 Elevation in the Central Nervous System Is Associated With Failure to Thrive in Alexander Disease

Annals of Clinical and Translational Neurology, Volume 13, Issue 1, Page 144-156, January 2026.
ABSTRACT Objective Alexander disease (AxD) is a severe neurodegenerative disorder caused by gain‐of‐function mutations in the gene for GFAP, which lead to protein aggregation and a primary astrocytopathy. Symptoms vary, but failure to thrive (FTT) and frequent emesis are common and cause significant morbidity. Here we investigate GDF15, a member of the
Tracy L. Hagemann, Michelle M. Sonsalla, Cora Luzinski, Fernando Zacahua, David A. Harris, Dudley W. Lamming, Albee Messing   +6 more
wiley   +1 more source

LOCALIZATION OF TIGHT JUNCTIONS BETWEEN TANYCYTE-LIKE CELLS OF THE SULCUS MEDIANUS ORGANUM IN RAT BRAIN

The Iraqi Journal of Medical Sciences, 2017
Background: Tanycytes are highly specialized ependymal cells (ECs) that line the regions of circumventricular organs (CVOs) where the blood-brain barrier is absent.
Fadhil H. Ahmed, Muthanna A. Al-Kaabi, Sarmad E. Al-Marsoummi, Hayder A. Al-Aubaidy   +3 more
doaj   +6 more sources

Impact of Growth Hormone on Microglial and Astrocytic Function

Journal of Integrative Neuroscience
The role of growth hormone (GH) in the central nervous system (CNS) involves neuroprotection, neuroregeneration, formation of axonal projections, control of cognition, and regulation of metabolism.
Mariana R. Tavares, Frederick Wasinski, Martin Metzger, Jose Donato Jr.   +3 more
doaj   +1 more source

Tanycyte-Like Cells Derived From Mouse Embryonic Stem Culture Show Hypothalamic Neural Stem/Progenitor Cell Functions [PDF]

Tanycytes have recently been accepted as neural stem/progenitor cells in the postnatal hypothalamus. Persistent retina and anterior neural fold homeobox (Rax) expression is characteristic of tanycytes in contrast to its transient expression of whole ...
Kano, Mayuko, Tsunekawa, Taku, Hagiwara, Daisuke, Yamada, Tomiko, Kasai, Takatoshi, Onoue, Takeshi, Sugiyama, Mariko, Sakakibara, Mayu, Goto, Motomitsu, Banno, Ryoichi, Ito, Yoshihiro, Suga, Hidetaka, Takagi, Hiroshi, Ishihara, Takeshi, Soen, Mika, Mitsumoto, Kazuki, Ozaki, Hajime, Arima, Hiroshi, Iwama, Shintaro, 94289, 94284, 94283, 94282, 94281, 94288, 94287, 94286, 94285, 94280, 94279, 94295, 94294, 94293, 94292, 94297, 94296, 94291, 94290   +37 more
core  

The Identification and Characterization of Tanycyte Stem Cells

The formation of the brain is perhaps one of the most remarkable processes in biology, and at its core, is orchestrated by neural progenitors that give rise to a wide array of cell types in a precise, temporally coordinated manner.
Fong, Harmony
core   +1 more source

Glial Endozepines Inhibit Feeding-Related Autonomic Functions by Acting at the Brainstem Level

Frontiers in Neuroscience, 2017
Endozepines are endogenous ligands for the benzodiazepine receptors and also target a still unidentified GPCR. The endozepine octadecaneuropeptide (ODN), an endoproteolytic processing product of the diazepam-binding inhibitor (DBI) was recently shown to ...
Florent Guillebaud, Clémence Girardet, Anne Abysique, Stéphanie Gaigé, Rym Barbouche, Jérémy Verneuil, André Jean, Jérôme Leprince, Marie-Christine Tonon, Michel Dallaporta, Bruno Lebrun, Jean-Denis Troadec   +11 more
doaj   +1 more source