Results 41 to 50 of about 49,724 (234)

AN EXPERIMENTAL STUDY OF THE EFFECT OF RARE POLYMORPHISMS OF HUMAN HBB, HBD AND F9 PROMOTER TATA BOXES ON THE KINETICS OF INTERACTION WITH THE TATA-BINDING PROTEIN

Вавиловский журнал генетики и селекции, 2018
Human genes HBB, HBD and F9 belong to the hematopoiesis system. The deficiency or excess of these genes’ products is the cause of hereditary thalassemias of various severity and haemophilia B Leyden.
E. B. Sharypova, I. A. Drachkova, E. V. Kashina, D. A. Rasskazov, P. M. Ponomarenko, M. P. Ponomarenko, N. А. Kolchanov, L. K. Savinkova   +7 more
doaj   +1 more source

Estimating absolute configurational entropies of macromolecules: the minimally coupled subspace approach. [PDF]

PLoS ONE, 2010
We develop a general minimally coupled subspace approach (MCSA) to compute absolute entropies of macromolecules, such as proteins, from computer generated canonical ensembles.
Ulf Hensen, Oliver F Lange, Helmut Grubmüller   +2 more
doaj   +1 more source

Molecular dissection studies of TAC1, a transcription activator of Candida drug resistance genes of the human pathogenic fungus Candida albicans

Frontiers in Microbiology, 2023
The up-regulation of ABC transporters Cdr1p and Cdr2p that efflux antifungal azole drugs are a leading cause of Multi-Drug Resistance (MDR) in the white fungus Candida albicans. C.
Tushar Jain, Tushar Jain, Pankaj Mishra, Sushil Kumar, Gautam Panda, Gautam Panda, Dibyendu Banerjee, Dibyendu Banerjee   +7 more
doaj   +1 more source

Candidate SNP markers of reproductive potential are predicted by a significant change in the affinity of TATA-binding protein for human gene promoters

BMC Genomics, 2018
Background The progress of medicine, science, technology, education, and culture improves, year by year, quality of life and life expectancy of the populace.
Irina V. Chadaeva, Petr M. Ponomarenko, Dmitry A. Rasskazov, Ekaterina B. Sharypova, Elena V. Kashina, Dmitry A. Zhechev, Irina A. Drachkova, Olga V. Arkova, Ludmila K. Savinkova, Mikhail P. Ponomarenko, Nikolay A. Kolchanov, Ludmila V. Osadchuk, Alexandr V. Osadchuk   +12 more
doaj   +1 more source

TLR2-dependent inhibition of macrophage responses to IFN-gamma is mediated by distinct, gene-specific mechanisms. [PDF]

PLoS ONE, 2009
Mycobacterium tuberculosis uses multiple mechanisms to avoid elimination by the immune system. We have previously shown that M. tuberculosis can inhibit selected macrophage responses to IFN-gamma through TLR2-dependent and -independent mechanisms.
Sarah A Benson, Joel D Ernst
doaj   +1 more source

Fluorescence-based Analyses of the Effects of Full-length Recombinant TAF130p on the Interaction of TATA Box-binding Protein with TATA Box DNA [PDF]

Journal of Biological Chemistry, 2001
We have used a combination of fluorescence anisotropy spectroscopy and fluorescence-based native gel electrophoresis methods to examine the effects of the transcription factor IID-specific subunit TAF130p (TAF145p) upon the TATA box DNA binding properties of TATA box-binding protein (TBP). Purified full-length recombinant TAF130p decreases TBP-TATA DNA
U, Banik, J M, Beechem, E, Klebanow, S, Schroeder, P A, Weil   +4 more
openaire   +2 more sources

The functions of y-box binding proteins in caenorhabditis elegans [PDF]

, 2015
Members of the highly conserved family of Y-box binding proteins (YBPs) have a broad spectrum of functions in both transcriptional and post-transcriptional regulation of gene expression.
Arnold, Andreas
core   +1 more source

Molecular structure of promoter-bound yeast TFIID

Nature Communications, 2018
Transcription preinitiation complex assembly begins with the recognition of the gene promoter by the TATA-box Binding Protein-containing TFIID complex.
Olga Kolesnikova, Adam Ben-Shem, Jie Luo, Jeff Ranish, Patrick Schultz, Gabor Papai   +5 more
doaj   +1 more source

Pontin52, an interaction partner of β-catenin, binds to the TATA box binding protein

Proceedings of the National Academy of Sciences, 1998
β-catenin, the vertebrate homolog of the Drosophila Armadillo protein, has been shown to have dual cellular functions, as a component of both the cadherin-catenin cell adhesion complex and the Wnt signaling pathway.
A, Bauer, O, Huber, R, Kemler
openaire   +3 more sources

The Ewing sarcoma protein (EWS) binds directly to the proximal elements of the macrophage-specific promoter of the CSF-1 receptor (csf1r) gene [PDF]

, 2008
Many macrophage-specific promoters lack classical transcriptional start site elements such as TATA boxes and Sp1 sites. One example is the CSF-1 receptor (CSF-1R, CD115,c-fms), which is used as a model of the transcriptional regulation of macrophage ...
Constantin, Myrna, Sharma, Sudarshana M., Sasmono, Tedjo, Himes, S. Roy, Bronisz, Agnieszka, Hume, David A., Ostrowski, Michael C., Ross, Ian L.   +7 more
core   +1 more source