Results 21 to 30 of about 49,724 (234)

The Crystal Structure of a Hyperthermophilic Archaeal TATA-box Binding Protein [PDF]

Journal of Molecular Biology, 1996
This study analyzes the three-dimensional structure of the TATA-box binding protein (TBP) from the hyperthermophilic archaea Pyrococcus woesei. The crystal structure of P. woesei TBP (PwTBP) was solved at 2.2 A by X-ray diffraction and as expected from sequence homology (36% to 41% identical to eukaryotic TBPs) its overall structure is very similar to ...
B S, DeDecker, R, O'Brien, P J, Fleming, J H, Geiger, S P, Jackson, P B, Sigler   +5 more
openaire   +2 more sources

Analysis of a hybrid TATA box binding protein originating from mesophilic and thermophilic donor organisms [PDF]

, 2010
The TATA Box Binding Protein (TBP) is a 20 kD protein that is essential and universally conserved in eucarya and archaea. Especially among archaea, organisms can be found that live below 0°C as well as organisms that grow above 100°C.
Soppa, Jörg, Hauser, Karin, Kopitz, Annette   +2 more
core   +1 more source

Molecular determinants underlying functional innovations of TBP and their impact on transcription initiation

Nature Communications, 2020
The TATA-box binding protein (TBP) is required for transcription initiation in archaea and eukaryotes. Here the authors delineate how TBP’s function has evolved new functional features through context-dependent interactions with various protein partners.
Charles N. J. Ravarani, Tilman Flock, Sreenivas Chavali, Madhanagopal Anandapadamanaban, M. Madan Babu, Santhanam Balaji   +5 more
doaj   +1 more source

ZNF384-Related Fusion Genes in Acute Lymphoblastic Leukemia

Cancer Control, 2023
Zinc finger protein 384 ( ZNF384 ) encodes a C2H2-type zinc finger protein that can function as a transcription factor. ZNF384 rearrangement in acute lymphoblastic leukemia (ALL) was first reported in 2002.
Liwen Zhu MS, Wenke Bai MS, Qianyi Cheng BS, Jianpei Fang MD   +3 more
doaj   +1 more source

The Small Nuclear RNA-activating Protein 190 Myb DNA Binding Domain Stimulates TATA Box-binding Protein-TATA Box Recognition [PDF]

Journal of Biological Chemistry, 2003
Human U6 small nuclear RNA (snRNA) gene transcription by RNA polymerase III requires cooperative promoter binding involving the snRNA-activating protein complex (SNAP(c)) and the TATA-box binding protein (TBP). To investigate the role of SNAP(c) for TBP function at U6 promoters, TBP recruitment assays were performed using full-length TBP and a mini ...
Craig S, Hinkley, Heather A, Hirsch, Liping, Gu, Brandon, LaMere, R William, Henry   +4 more
openaire   +2 more sources

A Small Trinucleotide Expansion in the TBP Gene Gives Rise to a Sporadic Case of SCA17 with Abnormal Putaminal Findings on MRI [PDF]

, 2008
A Japanese woman developed gait disturbances at 25 years of age, and subsequently underwent gradual changes in her personality. By the age of 42, she showed clear signs of dementia and cerebellar ataxia, and displayed behavioral abnormalities, choreic ...
Suzuki, Chieko, Tomiyama, Masahiko, Jackson, Mandy, Ikeda, Yoshio, Yamamoto-Watanabe, Yukiko, Watanabe, Mitsunori, Kawarabayashi, Takeshi, Shoji, Mikio, Wakasaya, Yasuhito, Monai, Natsuki, Kimura, Tamaki, Miki, Yasuo, Matsubara, Etsuro, Seino, Yusuke   +13 more
core   +1 more source

Architecture of TAF11/TAF13/TBP complex suggests novel regulation properties of general transcription factor TFIID

eLife, 2017
General transcription factor TFIID is a key component of RNA polymerase II transcription initiation. Human TFIID is a megadalton-sized complex comprising TATA-binding protein (TBP) and 13 TBP-associated factors (TAFs).
Kapil Gupta, Aleksandra A Watson, Tiago Baptista, Elisabeth Scheer, Anna L Chambers, Christine Koehler, Juan Zou, Ima Obong-Ebong, Eaazhisai Kandiah, Arturo Temblador, Adam Round, Eric Forest, Petr Man, Christoph Bieniossek, Ernest D Laue, Edward A Lemke, Juri Rappsilber, Carol V Robinson, Didier Devys, Làszlò Tora, Imre Berger   +20 more
doaj   +1 more source

A role for voltage-dependent anion channel Vdac1 in polyglutamine-mediated neuronal cell death. [PDF]

PLoS ONE, 2007
Expansion of trinucleotide repeats in coding and non-coding regions of genes is associated with sixteen neurodegenerative disorders. However, the molecular effects that lead to neurodegeneration have remained elusive.
Tanay Ghosh, Neeraj Pandey, Arindam Maitra, Samir K Brahmachari, Beena Pillai   +4 more
doaj   +1 more source

Cellular localization of Y-box binding protein 1 in brain tissue of rats, macaques, and humans [PDF]

, 2009
Background: The Y-box binding protein 1 (YB-1) is considered to be one of the key regulators of transcription and translation. However, so far only limited knowledge exists regarding its cellular distribution in the adult brain.Results: Analysis of YB-1 ...
Maria S Balda, Pekcec, A, Baumgaertner, Wolfgang, Balda Maria S, Pekcec, Anton, Wehmeyer, A, Baumgärtner Wolfgang, Potschka Heidrun, Baumgartner, W, Christina Fuest, Potschka, H, Unkruer, B, Wehmeyer Andrea, Fuest, C, Horn Anja, Anja Horn, Balda, MS, Heidrun Potschka, Anton Pekcec, Horn, Anja, Horn, A, Wolfgang Baumgärtner, Balda, Maria S., Unkrueer, Bernadette, Unkrüer Bernadette, Bernadette Unkrüer, Andrea Wehmeyer, Wehmeyer, Andrea, Fuest, Christina, Pekcec Anton, Potschka, Heidrun, Fuest Christina   +31 more
core   +1 more source

Drosophila TAF _II 230 and the transcriptional activator VP16 bind competitively to the TATA box-binding domain of the TATA box-binding protein [PDF]

Proceedings of the National Academy of Sciences, 1997
The transcription initiation factor TFIID, consisting of the TATA box-binding protein (TBP) and many TBP-associated factors (TAFs), plays a central role in both basal and activated transcription. An intriguing finding is that the 80-residue N-terminal region of Drosophila TAF II 230 [dTAF
J, Nishikawa, T, Kokubo, M, Horikoshi, R G, Roeder, Y, Nakatani   +4 more
openaire   +2 more sources