A conserved GA element in TATA-less RNA polymerase II promoters. [PDF]
PLoS ONE, 2011 Initiation of RNA polymerase (Pol) II transcription requires assembly of the pre-initiation complex (PIC) at the promoter. In the classical view, PIC assembly starts with binding of the TATA box-binding protein (TBP) to the TATA box.
Martin Seizl +6 more
doaj +3 more sources
Transcriptional regulation of the human ALDH1A1 promoter by the oncogenic homeoprotein TLX1/HOX11
Hematology Reports, 2009 The homeoprotein TLX1, which is essential to spleen organogenesis and oncogenic when aberrantly expressed in immature T cells, functions as a bifunctional transcriptional regulator, being capable of activation or repression depending on cell type and/or ...
Kim Rice +4 more
doaj +3 more sources
TATA-Box Binding Protein O-GlcNAcylation at T114 Regulates Formation of the B-TFIID Complex and Is Critical for Metabolic Gene Regulation. [PDF]
Mol Cell, 2020 Hardivillé S +9 more
europepmc +2 more sources
Bidirectional binding of the TATA box binding protein to the TATA box [PDF]
Proceedings of the National Academy of Sciences, 1997 By selective attachment of a DNA cleavage agent to specific residues in the yeast TATA box binding protein (yTBP), we demonstrate that, in solution, yTBP binds to the TATA boxes of both the adenovirus major late promoter and the yeast CYC1 promoter with only a modest preference in orientation and binds well to ...
J M, Cox +7 more
openaire +2 more sources
Hepatology, EarlyView., 2022 IL‐31 levels correlate with pruritus in patients with cholestatic and metabolic liver diseases Abstract Background and Aims Pruritus is associated with multiple liver diseases, particularly those with cholestasis, but the mechanism remains incompletely understood.
Jun Xu +20 more
wiley +1 more source
Selective Binding of the TATA Box-Binding Protein to the TATA Box-Containing Promoter: Analysis of Structural and Energetic Factors [PDF]
Biophysical Journal, 1998 We report the results of an energy-based exploration of the components of selective recognition of the TATA box-binding protein (TBP) to a TATA box sequence that includes 1) the interaction between the hydrophobic Leu, Pro, and Phe residues of TBP with the TA, AT, AA, TT, and CG steps, by ab initio quantum mechanical calculations; and 2) the free ...
Pardo, Leonardo +2 more
openaire +2 more sources
Comprehensive study in the inhibitory effect of berberine on gene transcription, including TATA box. [PDF]
PLoS ONE, 2011 Berberine (BBR) is an established natural DNA intercalator with numerous pharmacological functions. However, currently there are neither detailed reports concerning the distribution of this alkaloid in living cells nor reports concerning the relationship
Yugang Wang +6 more
doaj +1 more source
An experimental verification of the predicted effects of promoter TATA-box polymorphisms associated with human diseases on interactions between the TATA boxes and TATA-binding protein. [PDF]
PLoS ONE, 2013 Human genome sequencing has resulted in a great body of data, including a stunningly large number of single nucleotide polymorphisms (SNPs) with unknown phenotypic manifestations. Identification and comprehensive analysis of regulatory SNPs in human gene
Ludmila Savinkova +5 more
doaj +1 more source
TATA-box binding protein-associated factor 2 regulates grain size in rice
Crop Journal, 2023 Grain size, characterized by a combination of grain length, width, and thickness, is one of the major determinants of yield in rice. The present study identified TATA-box binding protein-associated factor 2 (TAF2) as an essential component regulating ...
Ling Jiang +8 more
doaj +1 more source
Stepwise Bending of DNA by a Single TATA-Box Binding Protein [PDF]
Biophysical Journal, 2006 The TATA-box Binding Protein (TBP) is required by all three eukaryotic RNA polymerases for the initiation of transcription from most promoters. TBP recognizes, binds to, and bends promoter sequences called ``TATA-boxes'' in the DNA. We present results from the study of individual Saccharomyces cerevisia TBPs interacting with single DNA molecules ...
S. F. TOLIC NORRELYKKE +4 more
openaire +6 more sources