Results 61 to 70 of about 45,863 (244)
The TATA-box motif and its impact on transcriptional gene regulation by miRNAs
Biomolecular Concepts, 2015 Emerging evidence suggests that components of the small RNAs pathway interact with chromatin to regulate nuclear events, such as gene transcription. However, it has recently been reported that in some cases, gene transcription regulation by cellular ...
Granados-Riveron Javier T. +1 more
doaj +1 more source
How global DNA unwinding causes non-uniform stress distribution and melting of DNA.
PLoS ONE, 2020 DNA unwinding is an important process that controls binding of proteins, gene expression and melting of double-stranded DNA. In a series of all-atom MD simulations on two DNA molecules containing a transcription start TATA-box sequence we demonstrate ...
Korbinian Liebl, Martin Zacharias
doaj +1 more source
A core promoter element downstream of the TATA box that is recognized by TFIIB
, 2005 We have defined a core promoter element downstream of the TATA box that is recognized by TFIIB. This involves a DNA-binding domain in TFIIB that is distinct from the helix-turn-helix motif (which recognizes an element upstream of the TATA box). The TFIIB
Deng, Wensheng, Roberts, Stefan G E
core +1 more source
Digital Technology's Role in Circular Waste Management: A Systematic Review
Business Strategy and the Environment, EarlyView.ABSTRACT Combining circular economy ideas with digital tools offers a game‐changing way to tackle global sustainability problems. This paper focuses on how digital changes and circular economy models link up. A review has been conducted for 112 articles from 2021 to September 2025, using PRISMA‐2020 methodology. This study covered new tech like AI, IoT,
Reza Eslamipoor
wiley +1 more source
Developmental Dynamics, EarlyView.Abstract Background The promoters and enhancers of heat shock genes, such as the 1.5‐kb promoter of the zebrafish hsp70l gene, are valuable tools for temporal activation of transgenes. It has been widely purported that heat shock treatments result in ubiquitous expression of hsp70l‐driven transgenes.
Jong‐Su Park, Xiangyun Wei
wiley +1 more source
Вавиловский журнал генетики и селекции, 2022 The GRIN1, ASCL3, and NOS1 genes are associated with various phenotypes of neuropsychiatric disorders. For instance, these genes contribute to the development of schizophrenia, Alzheimer’s and Parkinson’s diseases, and epilepsy.
E. B. Sharypova +4 more
doaj +1 more source
Dynamics of TBP binding to the TATA box [PDF]
SPIE Proceedings, 2008 Gene expression is highly controlled and regulated in living cells. One of the first steps in gene transcription is recognition of the promoter site by the TATA box Binding Protein (TBP). TBP recruits other transcriptions factors and eventually the RNA polymerase II to transcribe the DNA in mRNA.
Peter Schluesche +3 more
openaire +1 more source
TATA-box motif targeted siRNAs activate the promoter activities of 16 genes.
, 2014 (A) Schematic diagram for designing siRNAs that target the TATA-box motif. The consensus sequence of TATA-box motif was highlighted. SiRNAs targeting the TATA-box-centered position (CEN), siRNAs targeting the positions in upstream (UP) or downstream (DN)
Miaomiao Fan (548828) +6 more
core +1 more source
EMSA showing the inhibition of the binding of TsTBP1 to TATA-box of pAT5 by the anti-pTsTBP1-C.
, 2015 Lane 1: labeled TATA-box pAT5 dsDNA-biotin probe without T. solium nuclear extract; lane 2: TATA-box pAT5 interaction with T. solium nuclear extract; lane 3: TATA-box pAT5 plus T. solium nuclear extract and anti-pTsTBP1-C antibodies; lane 4: T.
Ángel Zarain-Herzberg (821381) +5 more
core +1 more source
Journal of Clinical Laboratory Analysis, EarlyView.This study developed a PCR‐based fragment analysis assay for UGT1A1 rs3064744 targeting TA5 (*36), TA6 (*1), TA7 (*28), and TA8 (*37). The assay was CLIA validated with data showing 100% concordance and a sensitivity of 0.5 ng/uL. The assay was then implemented in a patient cohort of n = 940 and the results compared with PharmacoScan.
Ryan N. Baugher +6 more
wiley +1 more source