Results 1 to 10 of about 31,353 (262)

Therapeutic VEGFC treatment provides protection against traumatic-brain-injury-driven tauopathy pathogenesis [PDF]

Cell Reports
Summary: Traumatic brain injury (TBI) increases one’s risk of developing Alzheimer’s disease and tauopathy. Yet, the mechanisms linking TBI to neurodegenerative disease remain poorly defined.
Ana Royo Marco, Katherine R. Bruch, Maureen N. Cowan, Julia G. Dill, Katelyn A. Moore, Ashley C. Bolte, John R. Lukens   +6 more
doaj   +2 more sources

DAP12 deletion reduces neuronal SLIT2 and demyelination and enhances brain resilience in female tauopathy mice [PDF]

Molecular Neurodegeneration
Background Pathogenic tau accumulation drives neurodegeneration in Alzheimer’s disease (AD). Enhancing the aging brain’s resilience to tau pathology would lead to novel therapeutic strategies.
Hao Chen, Li Fan, Qi Guo, Man Ying Wong, Jingjie Zhu, Nessa Foxe, Winston Wang, Aviram Nessim, Gillian Carling, Bangyan Liu, Chloe Lopez-Lee, Yige Huang, Sadaf Amin, Tark Patel, Sue-Ann Mok, Won-min Song, Bin Zhang, Shiaoching Gong, Qin Ma, Hongjun Fu, Li Gan, Wenjie Luo   +21 more
doaj   +2 more sources

Distinct Poly(A) nucleases have differential impact on sut-2 dependent tauopathy phenotypes.

Neurobiology of Disease, 2021
Aging drives pathological accumulation of proteins such as tau, causing neurodegenerative dementia disorders like Alzheimer's disease. Previously we showed loss of function mutations in the gene encoding the poly(A) RNA binding protein SUT-2/MSUT2 ...
Rebecca L. Kow, Timothy J. Strovas, Pamela J. McMillan, Ashley M. Jacobi, Mark A. Behlke, Aleen D. Saxton, Caitlin S. Latimer, C. Dirk Keene, Brian C. Kraemer   +8 more
doaj   +1 more source

Positron Emission Tomography in Animal Models of Tauopathies

Frontiers in Aging Neuroscience, 2022
The microtubule-associated protein tau (MAPT) plays an important role in Alzheimer’s disease and primary tauopathy diseases. The abnormal accumulation of tau contributes to the development of neurotoxicity, inflammation, neurodegeneration, and cognitive ...
Lei Cao, Lei Cao, Yanyan Kong, Bin Ji, Yutong Ren, Yihui Guan, Ruiqing Ni, Ruiqing Ni   +7 more
doaj   +1 more source

Age-related impairment of ultrasonic vocalization in Tau.P301L mice: possible implication for progressive language disorders. [PDF]

PLoS ONE, 2011
Tauopathies, including Alzheimer's Disease, are the most frequent neurodegenerative diseases in elderly people and cause various cognitive, behavioural and motor defects, but also progressive language disorders. For communication and social interactions,
Clément Menuet, Yves Cazals, Christian Gestreau, Peter Borghgraef, Lies Gielis, Mathias Dutschmann, Fred Van Leuven, Gérard Hilaire   +7 more
doaj   +1 more source

Seizures are a druggable mechanistic link between TBI and subsequent tauopathy

eLife, 2021
Traumatic brain injury (TBI) is a prominent risk factor for dementias including tauopathies like chronic traumatic encephalopathy (CTE). The mechanisms that promote prion-like spreading of Tau aggregates after TBI are not fully understood, in part due to
Hadeel Alyenbaawi, Richard Kanyo, Laszlo F Locskai, Razieh Kamali-Jamil, Michèle G DuVal, Qing Bai, Holger Wille, Edward A Burton, W Ted Allison   +8 more
doaj   +1 more source

Implication of type 4 NADPH oxidase (NOX4) in tauopathy

Redox Biology, 2022
Aggregates of the microtubule-associated protein tau are a common marker of neurodegenerative diseases collectively termed as tauopathies, such as Alzheimer's disease (AD) and frontotemporal dementia.
Enrique Luengo, Paula Trigo-Alonso, Cristina Fernández-Mendívil, Ángel Nuñez, Marta del Campo, César Porrero, Nuria García-Magro, Pilar Negredo, Sergio Senar, Cristina Sánchez-Ramos, Juan A. Bernal, Alberto Rábano, Jeroen Hoozemans, Ana I. Casas, Harald H.H.W. Schmidt, Manuela G. López   +15 more
doaj   +1 more source

Increased neuronal activity in motor cortex reveals prominent calcium dyshomeostasis in tauopathy mice

Neurobiology of Disease, 2021
Perturbed neuronal Ca2+ homeostasis is implicated in Alzheimer's disease, which has primarily been demonstrated in mice with amyloid-β deposits but to a lesser and more variable extent in tauopathy models.In this study, we injected AAV to express Ca2 ...
Qian Wu, Yang Bai, Wei Li, Erin E. Congdon, Wenke Liu, Yan Lin, Changyi Ji, Wen-Biao Gan, Einar M. Sigurdsson   +8 more
doaj   +1 more source

Microglial activation arises after aggregation of phosphorylated-tau in a neuron-specific P301S tauopathy mouse model [PDF]

, 2020
Alzheimer's disease, progressive supranuclear palsy and frontotemporal dementia are characterized by neuronal expression of aberrant tau protein, tau hyperphosphorylation (pTAU), tau aggregation and neurofibrillary tangle formation sequentially ...
Carmans, Sofie, de Vries, Helga E., Franssen, Marc, Kamermans, Alwin, Popovic, Marko, Roucourt, Bart, Schouten, Marijn, Sobrino, Tomás, van der Pol, Susanne M.A., van Olst, Lynn, Vandenbroucke, Roosmarijn, Verhaege, Daan, Wever, Dennis, Ytebrouck, Ellen   +13 more
core   +1 more source

Magnetic Resonance Imaging in Tauopathy Animal Models

Frontiers in Aging Neuroscience, 2022
The microtubule-associated protein tau plays an important role in tauopathic diseases such as Alzheimer’s disease and primary tauopathies such as progressive supranuclear palsy and corticobasal degeneration.
Ruiqing Ni, Ruiqing Ni
doaj   +1 more source