Results 101 to 110 of about 31,353 (262)
Frontiers in Pharmacology, 2018 Calcium/calmodulin-dependent protein kinase II (CaMKII) is abundant in the brain and functions as a mediator of calcium signaling. We found that the relative activity of CaMKII was significantly lower in the WT mouse brains than in the Pin1-/- mouse ...
Taiki Shimizu +4 more
doaj +1 more source
Lifelong behavioral and neuropathological consequences of repetitive mild traumatic brain injury [PDF]
, 2017 Objective: Exposure to repetitive concussion, or mild traumatic brain injury (mTBI), has been linked with increased risk of long-term neurodegenerative changes, specifically chronic traumatic encephalopathy (CTE).
Acker, Christopher M. +11 more
core +2 more sources
Brain Pathology, EarlyView.Immunohistochemistry for TDP‐43: (A)—Dentate gyrus; (B)—Temporal lobe. Abstract Frontotemporal dementia (FTD) is the second most common cause of early‐onset dementia, typically manifesting before the age of 65, with a mean onset at 58 years. FTD may encompass a spectrum of neurodegenerative disorders resulting from frontotemporal lobar degeneration ...
Karen Daniela Román +13 more
wiley +1 more source
Frontiers in Aging Neuroscience, 2019 Globular glial tauopathies (GGTs) have heterogeneous presentations with little available information regarding typical clinical manifestations. We report on a case of atypical primary progressive aphasia (PPA) due to comorbid GGT and limbic transactive ...
Robert Rusina +11 more
doaj +1 more source
Modeling Chronic Traumatic Encephalopathy: The Way Forward for Future Discovery [PDF]
, 2015 Despite the extensive media coverage associated with the diagnosis of chronic traumatic encephalopathy (CTE), our fundamental understanding of the disease pathophysiology remains in its infancy.
Anthony L. Petraglia +9 more
core +2 more sources
Heritability in frontotemporal tauopathies
Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, 2019 AbstractIntroductionExploring the degree of heritability in a large cohort of frontotemporal lobar degeneration with tau‐immunopositive inclusions (FTLD‐tau) and determining if different FTLD‐tau subtypes are associated with stronger heritability will provide important insight into disease pathogenesis.MethodsUsing modified Goldman pedigree ...
Shelley L. Forrest +9 more
openaire +3 more sources
Rapid generation of prion disease models using AAV‐delivered PrP variants in knockout mice
Brain Pathology, EarlyView.We developed a rapid AAV‐based system to generate prion disease models in weeks rather than months. Following systemic AAV9P31 delivery of modified PrP to knockout mice, we achieved brain‐wide expression and successful propagation of both classical (RML) and atypical (GSS‐A117V) prion strains.
Maitena San‐Juan‐Ansoleaga +11 more
wiley +1 more source
Presymptomatic change in microRNAs modulates Tau pathology. [PDF]
, 2018 MicroRNAs (miRs) are 18~23 nucleotides long non-coding RNAs that regulate gene expression. To explore whether miR alterations in tauopathy contribute to pathological conditions, we first determined which hippocampal miRs are altered at the presymptomatic
Ali, Y.O. +6 more
core +2 more sources
From mechanism to phenotype: What fits in a basket trial
Epilepsia, EarlyView.
Kette D. Valente
wiley +1 more source
Brain Pathology, EarlyView.Neuritic plaques increase in the intermediate stage of Alzheimer's neuropathological change. The intermediate stage of Alzheimer's disease was investigated by transcriptomics and immunohistochemistry. This revealed that inflammasome sensors NLRP1, NLRP3, and AIM2 oligomerize with ASC speck to form the inflammasome complex and initiate the downstream ...
Juan Pablo de Rivero Vaccari +10 more
wiley +1 more source