Results 111 to 120 of about 31,353 (262)

Role of FK506 binding protein 51 in central nervous system diseases

Frontiers in Molecular Neuroscience
FK506-binding protein 51 (FKBP51) is a pivotal molecular chaperone and scaffolding protein that integrates and modulates multiple signaling pathways—including those involving HSP90, the glucocorticoid receptor, AKT, and NF-κB—through its FK1, FK2, and ...
Haokun Peng, Yanhao Wei, Yanmei Qiu, Rentang Bi, Longhai Zeng, Bo Hu, Yanan Li   +6 more
doaj   +1 more source

Amyloid β1-42 (Aβ1-42) Induces the CDK2-Mediated Phosphorylation of Tau through the Activation of the mTORC1 Signaling Pathway While Promoting Neuronal Cell Death

Frontiers in Molecular Neuroscience, 2017
Alzheimer’s disease (AD) is a neurodegenerative disorder, characterized by cognitive impairment and memory loss. Amyloid β1-42 (Aβ) and hyper-phosphorylation of microtubule-associated protein tau have been considered as major histological features in AD.
Ki Hoon Lee, Sei-Jung Lee, Hyun Jik Lee, Gee Euhn Choi, Young Hyun Jung, Dah Ihm Kim, Amr Ahmed Gabr, Amr Ahmed Gabr, Jung Min Ryu, Ho Jae Han   +9 more
doaj   +1 more source

The Importance of Tau Phosphorylation for Neurodegenerative Diseases [PDF]

, 2013
Fibrillar deposits of highly phosphorylated tau are a key pathological feature of several neurodegenerative tauopathies including Alzheimer’s disease and some frontotemporal dementias.
Christopher C. J. Miller, Diane P. Hanger, Simon Lovestone, Wendy Noble   +3 more
core   +2 more sources

Neurodegenerative Disease Tauopathies

Annual Review of Pathology: Mechanisms of Disease
Tauopathies are a diverse group of progressive and fatal neurodegenerative diseases characterized by aberrant tau inclusions in the central nervous system. Tau protein forms pathologic fibrillar aggregates that are typically closely associated with neuronal cell death, leading to varied clinical phenotypes including dementia, movement disorders, and ...
Creekmore, Benjamin C., Watanabe, Ryohei, Lee, Edward B.   +2 more
openaire   +2 more sources

E3 ligase Praja1 mediates ubiquitination and degradation of microtubule‐associated protein tau

The FEBS Journal, EarlyView.
E3 ligase Praja1, but not its paralogue Praja2, recognizes and ubiquitinates tau protein for proteasomal degradation. This newly identified function of Praja1‐mediated tau degradation suggests its role in protein quality control, which may provide insights into the pathogenesis of tauopathies.
Shiho Aoki, Wataru Onodera, Akihiko Takashima, Kotaro Kawasaki, Kazuki Imadegawa, Hikaru Kurahashi, Mizuho Oishi, Toru Asahi, Yoshiyuki Soeda   +8 more
wiley   +1 more source

Prefoldin 5 is a microtubule-associated protein that suppresses Tau aggregation and neurotoxicity

eLife
Tauopathies represent a major class of neurodegenerative disorders associated with intracellular aggregates of the microtubule-associated protein Tau.
Anjali Bisht, Srikanth Pippadpally, Snehasis Majumder, Athulya T Gopi, Abhijit Das, Chandan Sahi, Mani Ramaswami, Vimlesh Kumar   +7 more
doaj   +1 more source

Muscarinic receptor-dependent long term depression in the perirhinal cortex and recognition memory are impaired in the rTg4510 mouse model of tauopathy. [PDF]

, 2018
This is the final version of the article. Available from the publisher via the DOI in this record.Neurodegenerative diseases affecting cognitive dysfunction, such as Alzheimer's disease and fronto-temporal dementia, are often associated impairments in ...
Barker, GRI, Brown, JT, Randall, AD, Scullion, SE, Warburton, EC   +4 more
core   +3 more sources

Co‐localization of tau and TDP‐43 after extracellular vesicle delivery to cells

The FEBS Journal, EarlyView.
Extracellular vesicles (EVs) derived from donor cells transfected with EGFP–2N4R‐tau or mCherry‐wtTDP‐43 were taken up by recipient cells, leading to cytosolic co‐localization of tau and TDP‐43. Molecular modeling revealed that tau and TDP‐43 directly interact through hydrogen bonding, suggesting a mechanistic link underlying their co‐pathology ...
Farhang Aliakbari, Kathryn Volkening, Zahra Nayeri, Aysegul Yucel Polat, Neil Donison, Jacqueline Palik, Michael J. Strong   +6 more
wiley   +1 more source

A Novel Model of Mixed Vascular Dementia Incorporating Hypertension in a Rat Model of Alzheimer's Disease. [PDF]

, 2019
Alzheimer's disease (AD) and mixed dementia (MxD) comprise the majority of dementia cases in the growing global aging population. MxD describes the coexistence of AD pathology with vascular pathology, including cerebral small vessel disease (SVD ...
Ahmadian, Akiyama, Areosa, Attems, Babcock, Bailey, Baker, Baumgart, Beas, Beauchet, Biancardi, Bouras, Bubber, Bueche, Burm, Calkins, Cao, Cerejeira, Cifuentes, Cohen, Coisne, Csiszar, Custodio, de la Torre, De Reuck, Deane, Dey, Di Marco, Donahue, Du, Engelmann, Fan, Farkas, Feihl, Ferrero, Ferri, Fiandaca, Fischer, Frautschy, Galisova, Gallart-Palau, Gattu, Gattu, Ghosh, Giri, Giri, Goel, Goetzl, Gottesman, Grammas, Gratton, Grinberg, Hainsworth, Hainsworth, Harrison, Heagerty, Hebert, Held, Hernandez, Hoshi, Iadecola, Infante-Garcia, Jalal, Jandke, Jellinger, Jiang, Jolivel, Kaiser, Kalaria, Kalinowska, Kanekiyo, Kantak, Katsouri, Kelly, Kelly, Khan, Khoshnam, Kim, Kim, Kitaguchi, Klakotskaia, Koundal, Kovacs, Krebs, Kruyer, Kwon, Lafosse, Lan, Launer, Liu, Liu, Looi, Lukatela, Marfany, McKee, Meissner, Mendez, Meneses, Moody, Munoz-Moreno, Nabika, Ngandu, Oberlin, Okamoto, Petrovitch, Petrovitch, Pirici, Planton, Power, Ramirez-Gomez, Ramos-Rodriguez, Rizzi, Rodrigue, Romer, Sabbatini, Sayed, Schreiber, Sevigny, Shang, Shih, Sicard, Singh, Smith, Staals, Stoiljkovic, Swerdlow, Sydow, Takemori, Tang, Tayebati, Tayebati, Tayebati, Terry, Tomassoni, Traykov, Ueno, Valenti, Varghese, Vedder, Venkat, Venkat, Vinters, Vos, Walker, Wang, Wang, Wardlaw, Weaver, Wennberg, Wimo, Wimo, Xu, Yang, Yang, Yao, Yasar, Yu, Zhang, Zhang, Zhao, Zhou   +160 more
core   +1 more source

Proteostasis of organelles in aging and disease

The FEBS Journal, EarlyView.
Cells rely on regulated proteostasis mechanisms to keep their internal compartments functioning properly. When these mechanisms fail, damaged proteins accumulate, disrupting organelles, such as the nucleus, mitochondria, endoplasmic reticulum, Golgi, and lysosomes, as well as membraneless organelles, such as stress granules, processing bodies, the ...
Yara Nabawi, Cansu Doğan, Dunja Petrović, Gülce Perçin, Seda Koyuncu, David Vilchez   +5 more
wiley   +1 more source