Results 11 to 20 of about 31,353 (262)
Astrocytes in Tauopathies [PDF]
Frontiers in Neurology, 2020 Tauopathies are a group of neurodegenerative diseases characterized by the progressive accumulation across the brain of hyperphosphorylated aggregates of the microtubule-associated protein tau that vary in isoform composition, structural conformation and
Matthew J. Reid +4 more
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Seminars in Neurology, 2019 Tauopathies are rare neurodegenerative disorders related to microtubule-associated protein tau, which functions to stabilize microtubules. Pathological changes caused by overexpression or hyperphosphorylation of tau lead to the disengagement of tau from microtubules and accumulation of toxic intracellular inclusions.
Farwa, Ali, Keith, Josephs
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Immunotherapy for Tauopathies [PDF]
Journal of Molecular Neuroscience, 2011 Pathological tau protein is found in Alzheimer's disease and related tauopathies. The protein is hyperphosphorylated and/or mutated which leads to aggregation and neurotoxicity. Because cognitive functions correlate well with the degree of tau pathology, clearing these aggregates is a promising therapeutic approach.
Jiaping, Gu, Einar M, Sigurdsson
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Classification of tauopathies from human brain homogenates through salt-modulated tau amplification. [PDF]
Alzheimers DementAbstract INTRODUCTION Tauopathies are a heterogeneous group of neurodegenerative disorders defined by abnormal aggregation of tau protein. Although cryogenic electron microscopy (cryo‐EM) has uncovered disease‐specific tau structures, translating these insights into diagnostic tools remains difficult. METHODS We developed a heparin‐free, salt‐modulated
Santambrogio A +8 more
europepmc +2 more sources
Tau Protein Hyperphosphorylation and Aggregation in Alzheimer’s Disease and Other Tauopathies, and Possible Neuroprotective Strategies [PDF]
, 2016 Acknowledgments This work was supported by The Croatian Science Foundation grant No. IP-2014-09-9730 (“Tau protein hyperphosphorylation, aggregation, and trans-synaptic transfer in Alzheimer’s disease: cerebrospinal fluid analysis and assessment of ...
Babić Leko, Mirjana +11 more
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Tauopathy promotes spinal cord-dependent production of toxic amyloid-beta in transgenic monkeys
Signal Transduction and Targeted Therapy, 2023 Tauopathy, characterized by the hyperphosphorylation and accumulation of the microtubule-associated protein tau, and the accumulation of Aβ oligomers, constitute the major pathological hallmarks of Alzheimer’s disease.
Zhuchi Tu +13 more
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NAP (davunetide) rescues neuronal dysfunction in a Drosophila model of tauopathy [PDF]
, 2013 Alzheimer’s disease (AD) is a devastating neurodegenerative disease causing irreversible cognitive decline in the elderly. There is no disease-modifying therapy for this condition and the mechanisms underpinning neuronal dysfunction and neurodegeneration
Cowan, C.M., Mudher, A., Quraishe, S.
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Cellular and Molecular Life Sciences, 2007 Tau is a microtubule-associated protein predominantly expressed in nerve cells that promote microtubule assembly and microtubule stabilization. Tau is a cytosolic protein mainly present in axons and involved in anterograde axonal transport. In several neurodegenerative diseases, as for example Alzheimer's disease, tau metabolism is altered.
Hernández, Félix, Ávila, Jesús
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Frontiers in Neuroscience, 2023 Neurofibrillary tangles (NFTs) composed of hyperphosphorylated tau protein are primarily neuropathological features of a number of neurodegenerative diseases, collectively termed tauopathy.
Naruhiko Sahara, Rin Yanai
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The first NINDS/NIBIB consensus meeting to define neuropathological criteria for the diagnosis of chronic traumatic encephalopathy. [PDF]
, 2015 Chronic traumatic encephalopathy (CTE) is a neurodegeneration characterized by the abnormal accumulation of hyperphosphorylated tau protein within the brain. Like many other neurodegenerative conditions, at present, CTE can only be definitively diagnosed
Alvarez, Victor E +16 more
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