Results 21 to 30 of about 31,353 (262)

Astrocytic PYGM attenuates tau pathology by promoting lactate-mediated neuroprotection. [PDF]

Alzheimers Dement
Abstract INTRODUCTION Tauopathies are characterized by hyperphosphorylated tau accumulation and neurodegeneration. Although astrocytic metabolism is known to support neuronal health, the role of astrocytic glycogen metabolism, particularly the glycogenolytic enzyme PYGM (glycogen phosphorylase, muscle associated), in tauopathies remains unclear ...
Cao J, Meng J, Chen Y, Tang Z, Wang Y, Li K, Zhang X, Luo H, Li H, Wang Z, Zhang YW.   +10 more
europepmc   +2 more sources

Distinct Lysosomal Network Protein Profiles in Parkinsonian Syndrome Cerebrospinal Fluid. [PDF]

, 2016
BackgroundClinical diagnosis of parkinsonian syndromes like Parkinson's disease (PD), corticobasal degeneration (CBD) and progressive supranuclear palsy (PSP) is hampered by overlapping symptomatology and lack of diagnostic biomarkers, and definitive ...
Boman, Andrea, Boxer, Adam, Karydas, Anna, Kågedal, Katarina, Miller, Bruce, Rojas, Julio C, Seeley, William W, Svenningsson, Per, Svensson, Samuel   +8 more
core   +1 more source

Progressive tauopathy disrupts breathing stability and chemoreflexes during presumptive sleep in mice

Frontiers in Physiology, 2023
Rationale: Although sleep apnea occurs in over 50% of individuals with Alzheimer’s Disease (AD) or related tauopathies, little is known concerning the potential role of tauopathy in the pathogenesis of sleep apnea.
Alexandria B. Marciante, Carter Lurk, Luz Mata, Jada Lewis, Leah R. Reznikov, Gordon S. Mitchell   +5 more
doaj   +1 more source

Early alterations of neurovascular unit in the retina in mouse models of tauopathy

Acta Neuropathologica Communications, 2021
The retina, as the only visually accessible tissue in the central nervous system, has attracted significant attention for evaluating it as a biomarker for neurodegenerative diseases.
Fan Xia, Yonju Ha, Shuizhen Shi, Yi Li, Shengguo Li, Jonathan Luisi, Rakez Kayed, Massoud Motamedi, Hua Liu, Wenbo Zhang   +9 more
doaj   +1 more source

Sex-Related Motor Deficits in the Tau-P301L Mouse Model

Biomedicines, 2021
The contribution of mouse models for basic and translational research at different levels is important to understand neurodegenerative diseases, including tauopathies, by studying the alterations in the corresponding mouse models in detail.
Luana Cristina Camargo, Dominik Honold, Robert Bauer, N. Jon Shah, Karl-Josef Langen, Dieter Willbold, Janine Kutzsche, Antje Willuweit, Sarah Schemmert   +8 more
doaj   +1 more source

Mutant Tau knock-in mice display frontotemporal dementia relevant behaviour and histopathology [PDF]

, 2016
Peer ...
Drever, Benjamin D., Koss, David J., Platt, Bettina, Plucinska, Kaja, Riedel, Gernot, Robinson, Lianne, Stoppelkamp, Sandra, Veselcic, Peter   +7 more
core   +3 more sources

Pneumonia initiates a tauopathy [PDF]

The FASEB Journal, 2021
Abstract Pneumonia causes short‐ and long‐term cognitive dysfunction in a high proportion of patients, although the mechanism(s) responsible for this effect are unknown. Here, we tested the hypothesis that pneumonia‐elicited cytotoxic amyloid and tau variants: (1) are present in the circulation during infection; (2) lead to impairment
Ron Balczon, Mike T. Lin, Ji Young Lee, Adeel Abbasi, Phoibe Renema, Sarah B. Voth, Chun Zhou, Anna Koloteva, C. Michael Francis, Neel R. Sodha, Jean‐Francois Pittet, Brant M. Wagener, Jessica Bell, Chung‐Sik Choi, Corey E. Ventetuolo, Troy Stevens   +15 more
openaire   +2 more sources

Isoflurane anesthesia precipitates tauopathy and upper airways dysfunction in pre-symptomatic Tau.P301L mice: Possible implication for neurodegenerative diseases

Neurobiology of Disease, 2012
The postoperative cognitive decline resulting from volatile anesthesia is gaining acceptance as a major health problem. The common anesthetic isoflurane is suspected to precipitate neurodegeneration in Alzheimer's disease by unknown mechanisms.
Clément Menuet, Peter Borghgraef, Nicolas Voituron, Christian Gestreau, Lies Gielis, Herman Devijver, Mathias Dutschmann, Fred Van Leuven, Gérard Hilaire   +8 more
doaj   +1 more source

Prolonged tau clearance and stress vulnerability rescue by pharmacological activation of autophagy in tauopathy neurons

Nature Communications, 2020
Disruption of autophagy function in cellular and animal models of tauopathy increases tau aggregation. Here, the authors describe a small-molecule screen to identify compounds that promote autophagy clearance of tau and rescue disease-relevant phenotypes
M. Catarina Silva, Ghata A. Nandi, Sharon Tentarelli, Ian K. Gurrell, Tanguy Jamier, Diane Lucente, Bradford C. Dickerson, Dean G. Brown, Nicholas J. Brandon, Stephen J. Haggarty   +9 more
doaj   +1 more source

Loss of vesicular dopamine release precedes tauopathy in degenerative dopaminergic neurons in a Drosophila model expressing human tau. [PDF]

, 2013
While a number of genome-wide association studies have identified microtubule-associated protein tau as a strong risk factor for Parkinson's disease (PD), little is known about the mechanism through which human tau can predispose an individual to this ...
Chang, Hui-Yun, Chiang, Ann-Shyn, Chuang, Chia-Lung, Krantz, David E, Lu, Yu-Ning, Wu, Chia-Lin, Wu, Ting-Han   +6 more
core   +2 more sources