Analysis genome of Pseudotaxus chienii reveals insights into the origin and evolution of taxane biosynthesis [PDF]
Nature CommunicationsAs a sister genus to Taxus, Pseudotaxus holds significant importance for studying the origin and evolution of the taxane biosynthesis pathway. However, the reference genome of Pseudotaxus chienii is yet unavailable.
Mingshuang Wang +17 more
doaj +2 more sources
Spatial distribution of isoprenoid enzymes and MpABCG1 transporter influences sesquiterpene accumulation in Marchantia polymorpha oil bodies [PDF]
Communications BiologyMarchantia polymorpha oil bodies (OBs) are specialized cell structures housing a diverse array of C15-terpenes, called sesquiterpenes. These compounds act as herbivore repellents, yet the enzymes responsible for the biosynthesis of their precursors ...
Edith C. F. Forestier +5 more
doaj +2 more sources
Causal effect of gut microbiota metabolic pathways on CSAG1 expression in chondrosarcoma: a mendelian randomization analysis [PDF]
BMC CancerBackground Changes in gut microbiota metabolism might play an important role in the development of some cancers. However, the causal relationships of gut microbiome-related metabolic pathways in chondrosarcomas and the specific pathways affected remain ...
Xiaoyun Liu, Sen Yang, Liyun Liu
doaj +2 more sources
Engineering cyanobacteria as a new platform for producing taxol precursors directly from carbon dioxide [PDF]
Biotechnology for Biofuels and BioproductsTaxol serves as an efficient natural anticancer agent with extensive applications in the treatment of diverse malignancies. Although advances in synthetic biology have enabled the de novo synthesis of taxol precursors in various microbial chassis, the ...
Jialing Zhong +6 more
doaj +2 more sources
Paclitaxel biological synthesis promotes the innovation of anti‐cancer drugs [PDF]
Clin Transl MedClinical and Translational Medicine, Volume 15, Issue 2, February 2025.
Xiaolin Zhang, Gang Liu, Jianbin Yan
wiley +2 more sources
Intricate Metabolic Network for Paclitaxel Biosynthesis [PDF]
BioDesign ResearchPaclitaxel is a renowned broad-spectrum anticancer drug. With the establishment of a chromosome-level high-quality reference genome map of Taxus, recent research on paclitaxel biosynthesis has flourished. The oxetane ring is a distinctive chemical moiety
Yuanwei Gou +2 more
doaj +2 more sources
Biochemical synthesis of taxanes from mevalonate [PDF]
Synthetic and Systems BiotechnologyTaxanes are kinds of diterpenoids with important bioactivities, such as paclitaxel (taxol®) is an excellent natural broad-spectrum anticancer drug. Attempts to biosynthesize taxanes have made with limited success, mainly due to the bottleneck of the low ...
Jing Li +11 more
doaj +2 more sources
Taxane-Producing Fungi Isolated from Taxus globosa Tree Bark [PDF]
MicroorganismsThe taxane molecules extracted from the bark of trees from the Taxus genus demonstrate anticancer activity and are the main components of the drug paclitaxel.
Jocelyn Guadalupe Guevara-Sánchez +6 more
doaj +2 more sources
Reconstitution of early paclitaxel biosynthetic network [PDF]
Nature CommunicationsPaclitaxel is an anticancer therapeutic produced by the yew tree. Over the last two decades, a significant bottleneck in the reconstitution of early paclitaxel biosynthesis has been the propensity of heterologously expressed pathway cytochromes P450 ...
Jack Chun-Ting Liu +3 more
doaj +2 more sources
Designing Molecular Solar Thermal Systems Based on the Paternò–Büchi Reaction Coupled to Enzymatic Energy Release [PDF]
ChemSusChem, Volume 18, Issue 15, July 27, 2025.Molecular solar thermal systems urge for innovative building blocks to increase their present limits in storage density and light activation window. Here, a complete computational study of loading and unloading mechanisms for an experimentally inspired system based on the Paternò–Büchi reaction is presented.
Marta Delgado‐Gómez +5 more
wiley +2 more sources