Results 41 to 50 of about 1,120 (154)

Salicylic Acid-Responsive Factor TcWRKY33 Positively Regulates Taxol Biosynthesis in Taxus chinensis in Direct and Indirect Ways

Frontiers in Plant Science, 2021
Taxol is a rare secondary metabolite that accumulates considerably in Taxus species under salicylic acid (SA) and methyl jasmonate treatment. However, the molecular mechanism of its accumulation remains unclear.
Ying Chen, Ying Chen, Ying Chen, Hua Zhang, Hua Zhang, Hua Zhang, Meng Zhang, Meng Zhang, Meng Zhang, Wenli Zhang, Wenli Zhang, Wenli Zhang, Ziqi Ou, Ziqi Ou, Ziqi Ou, Zehang Peng, Zehang Peng, Zehang Peng, Chunhua Fu, Chunhua Fu, Chunhua Fu, Chunfang Zhao, Chunfang Zhao, Chunfang Zhao, Longjiang Yu, Longjiang Yu, Longjiang Yu   +26 more
doaj   +1 more source

Exploring optimal Taxol® CYP725A4 activity in Saccharomyces cerevisiae

Microbial Cell Factories, 2022
Background CYP725A4 catalyses the conversion of the first Taxol® precursor, taxadiene, to taxadiene-5α-ol (T5α-ol) and a range of other mono- and di-hydroxylated side products (oxygenated taxanes).
Behnaz Nowrouzi, Liang Lungang, Leonardo Rios-Solis   +2 more
doaj   +1 more source

In situ recovery of taxadiene using solid adsorption in cultivations with Saccharomyces cerevisiae [PDF]

, 2023
In this study, an engineered strain of Saccharomyces cerevisiae was used to produce taxadiene, a precursor in the biosynthetic pathway of the anticancer drug paclitaxel. Taxadiene was recovered in situ with the polymeric adsorbent Diaion © HP-20. Here we
Dimartino, Simone, Santoyo-Garcia, Jorge H, Galindo-Rodriguez, Giuseppe R, Rios-Solis, Leonardo   +3 more
core   +1 more source

DataSheet1_Elimination of enzymes catalysis compartmentalization enhancing taxadiene production in Saccharomyces cerevisiae.docx

, 2023
Taxadiene is an important precursor in taxol biosynthesis pathway, but its biosynthesis in eukaryotic cell factories is limited, which seriously hinders the biosynthesis of taxol.
Tianyu Dong (4764558), Wang Chen (559614), Mingdong Yao (3383978), Bingzhi Li (3398189), Wenhai Xiao (3495275), Chenglong Zhang (1668559), Ying Wang (11406)   +6 more
core   +1 more source

TcMYB29a, an ABA-Responsive R2R3-MYB Transcriptional Factor, Upregulates Taxol Biosynthesis in Taxus chinensis

Frontiers in Plant Science, 2022
Paclitaxel (Taxol), a highly modified diterpene agent mainly obtained from Taxus species, is the most widely used anticancer drug. Abscisic acid (ABA) is a well-known stress hormone that plays important roles in the secondary metabolism of plants, and it
Xiaoying Cao, Lingxia Xu, Ludan Li, Wen Wan, Jihong Jiang   +4 more
doaj   +1 more source

Identification and in-silico characterization of taxadien-5α-ol-O-acetyltransferase (TDAT) gene in Corylus avellana L.

PLoS ONE, 2021
Paclitaxel® (PC) is one of the most effective and profitable anti-cancer drugs. The most promising sources of this compound are natural materials such as tissue cultures of Taxus species and, more recently, hazelnut (Corylus avellana L.). A large part of
Mona Raeispour Shirazi, Sara Alsadat Rahpeyma, Sajad Rashidi Monfared, Jafar Zolala, Azadeh Lohrasbi-Nejad   +4 more
doaj   +1 more source

A new 2α,5α,10β,14β-tetraacetoxy-4(20),11-taxadiene (SIA) derivative overcomes paclitaxel resistance by inhibiting MAPK signaling and increasing paclitaxel accumulation in breast cancer cells. [PDF]

PLoS ONE, 2014
Tumor resistance due to multiple mechanisms seriously hinders the efficacy of chemotherapy drugs such as paclitaxel. The most widely studied P-glycoprotein inhibitors still have limited ability to reverse resistance in the clinic.
Mei Mei, Dan Xie, Yi Zhang, Jing Jin, Feng You, Yan Li, Jungui Dai, Xiaoguang Chen   +7 more
doaj   +1 more source

From SMILES Codes for Reactants and Products to Transition States With VeloxChem

Journal of Computational Chemistry, Volume 47, Issue 18, July 5, 2026.
Initial guesses for transition state optimizations are produced from a mere input of reactant and product SMILES codes, and achieved by interpolating generated force fields for reactants and products. The entire workflow scheme is implemented in the VeloxChem software.
Bastiaan van Hoorn, Patrick Norman, Mårten S. G. Ahlquist   +2 more
wiley   +1 more source

Strain‐Specific Biotransformation of Grape Marc by Lactic Acid Bacteria: Genomic Validation and Gut Microbiota Modulation

Food Frontiers, Volume 7, Issue 4, July 2026.
ABSTRACT Grape marc (GM) is a polyphenol‐rich winery byproduct that remains underutilized due to its complex fiber matrix, which limits the bioaccessibility of bound phenolics. While lactic acid fermentation (LAF) can enhance the release of these compounds, the strain‐specific metabolic fate of GM phenolics during digestion and colonic fermentation ...
Ziyao Liu, Hanjing Wu, Brendan Holland, Colin J. Barrow, Hafiz A. R. Suleria   +4 more
wiley   +1 more source

Taxadiene synthase structure and evolution of modular architecture in terpene biosynthesis [PDF]

Nature, 2010
With more than 55,000 members identified so far in all forms of life, the family of terpene or terpenoid natural products represents the epitome of molecular biodiversity. A well-known and important member of this family is the polycyclic diterpenoid Taxol (paclitaxel), which promotes tubulin polymerization and shows remarkable efficacy in cancer ...
Köksal, Mustafa, Jin, Yinghua, Coates, Robert M., Croteau, Rodney, Christianson, David W.   +4 more
openaire   +2 more sources