Results 21 to 30 of about 22,844 (235)
Drug-Resistant Breast Cancer: Dwelling the Hippo Pathway to Manage the Treatment
Breast Cancer: Targets and Therapy, 2021 Simran Kaur,1 Mohammad Zeeshan Najm,1 Mohammad Aasif Khan,2 Naseem Akhter,3 Vyas M Shingatgeri,1 Mudra Sikenis,1 Sadaf,4 Abdulaziz A Aloliqi5 1School of Bioscience, Apeejay Stya University, Gurugram, Haryana, India; 2Department of Biosciences, Jamia ...
Kaur S +7 more
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Frontiers in Pharmacology, 2020 BackgroundWe explored the therapeutic and prognostic effect of YAP/TAZ intensityinHER2-positive breast cancer patients. We also investigated the relationship between YAP/TAZ expression and Trastuzumab-resistance.MethodsWe collected clinicopathological ...
Jia-qi Yuan, Nian-hua Ding, Zhi Xiao
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Cellular and Molecular Gastroenterology and Hepatology, 2021 Background & Aims: Yes-associated protein (YAP) and its paralog transcriptional co-activator with post synaptic density protein, drosophila disc large tumor suppressor and zonula occludens-1-binding motif (TAZ) are 2 co-activators downstream of Hippo
Haichuan Wang +16 more
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Clinical and biological implications of Hippo pathway dysregulation in sarcomas
Forum of Clinical Oncology, 2019 Sarcomas are mesenchymal malignant tumors with poor prognosis and limited treatment options. Hippo pathway is a recently discovered pathway normally involved in organ development and wound healing. Hippo signaling is often altered in solid tumors.
Kyriazoglou Anastasios +4 more
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Cell Death Discovery, 2021 Long non-coding RNAs (lncRNAs) regulate numerous biological processes involved in both development and carcinogenesis. Hippo-YAP/TAZ signaling, a critical pathway responsible for organ size control, is often dysregulated in a variety of cancers. However,
Bowen Zhu +11 more
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Alternative Wnt Signaling Activates YAP/TAZ [PDF]
Cell, 2015 The transcriptional co-activators YAP and TAZ are key regulators of organ size and tissue homeostasis, and their dysregulation contributes to human cancer. Here, we discover YAP/TAZ as bona fide downstream effectors of the alternative Wnt signaling pathway.
Park, Hyun Woo +11 more
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TAZ Regulates the Cisplatin Resistance of Epithelial Ovarian Cancer Cells via the ANGPTL4/SOX2 Axis
Analytical Cellular Pathology, 2022 Objective. Epithelial ovarian cancer (EOC) is a fatal gynecological malignancy. This study explored the mechanism of TAZ in regulating drug sensitivity of cisplatin (DDP-)-resistant EOC cells through the ANGPTL4/SOX2 axis. Methods.
Caihong Li +3 more
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Protein & Cell, 2016 TAZ, a transcriptional coactivator with PDZ-binding motif, is encoded by WWTR1 gene (WW domain containing transcription regulator 1). TAZ is tightly regulated in the hippo pathway-dependent and -independent manner in response to a wide range of extracellular and intrinsic signals, including cell density, cell polarity, F-actin related mechanical stress,
Xin Zhou, Qun-Ying Lei
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eLifePreviously we showed that the hippo pathway transcriptional effectors, YAP and TAZ, are essential for Schwann cells (SCs) to develop, maintain and regenerate myelin . Although TEAD1 has been implicated as a partner transcription factor, the mechanisms by
Matthew Grove +7 more
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YAP/TAZ: Molecular pathway and disease therapy
MedComm, 2023 The Yes‐associated protein and its transcriptional coactivator with PDZ‐binding motif (YAP/TAZ) are two homologous transcriptional coactivators that lie at the center of a key regulatory network of Hippo, Wnt, GPCR, estrogen, mechanical, and metabolism ...
Yuzi Wei +5 more
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