Results 31 to 40 of about 22,844 (235)

The Role and Activation Mechanism of TAZ in Hierarchical Microgroove/Nanopore Topography-Mediated Regulation of Stem Cell Differentiation

International Journal of Nanomedicine, 2021
Penghui Hu,1,2,* Qian Gao,1,2,* Huimin Zheng,1,2 Yujuan Tian,1,2 Guoying Zheng,1 Xiaoyu Yao,1 Junjiang Zhang,1 Xudong Wu,2 Lei Sui1 1Department of Prosthodontics, Tianjin Medical University School and Hospital of Stomatology, Tianjin, People’s ...
Hu P, Gao Q, Zheng H, Tian Y, Zheng G, Yao X, Zhang J, Wu X, Sui L   +8 more
doaj  

TNF receptor–related factor 3 inactivation promotes the development of intrahepatic cholangiocarcinoma through NF‐κB‐inducing kinase–mediated hepatocyte transdifferentiation

Hepatology, EarlyView., 2022
Abstract Background and Aims Intrahepatic cholangiocarcinoma (ICC) is a deadly but poorly understood disease, and its treatment options are very limited. The aim of this study was to identify the molecular drivers of ICC and search for therapeutic targets.
Yuto Shiode, Takahiro Kodama, Satoshi Shigeno, Kazuhiro Murai, Satoshi Tanaka, Justin Y. Newberg, Jumpei Kondo, Shogo Kobayashi, Ryoko Yamada, Hayato Hikita, Ryotaro Sakamori, Hiroshi Suemizu, Tomohide Tatsumi, Hidetoshi Eguchi, Nancy A. Jenkins, Neal G. Copeland, Tetsuo Takehara   +16 more
wiley   +1 more source

Verteporfin reverses progestin resistance through YAP/TAZ-PI3K-Akt pathway in endometrial carcinoma

Cell Death Discovery, 2023
Progestin resistance is a problem for patients with endometrial carcinoma (EC) who require conservative treatment with progestin, and its underlying mechanisms remain unclear. YAP and TAZ (YAP/TAZ), downstream transcription coactivators of Hippo pathway,
Lina Wei, Xiaohong Ma, Yixin Hou, Tianyi Zhao, Rui Sun, Chunping Qiu, Yao Liu, Ziyi Qiu, Zhiming Liu, Jie Jiang   +9 more
doaj   +1 more source

Research Advances in Targeting the YAP/TAZ Signaling Pathway 
to Improve Cancer Immunotherapy

Chinese Journal of Lung Cancer
Despite the groundbreaking advances in cancer immunotherapy achieved by immune checkpoint inhibitors (ICIs), their efficacy remains limited by the immunosuppressive tumor microenvironment (TME).
Pingxu ZHANG, Yiyi ZHAN
doaj   +1 more source

The political philosophy and ontology of autonomous zones

Интеллект. Инновации. Инвестиции
The article reveals the content of the Temporary Autonomous Zones’ conception (TAZ), proposed by the American anarchist thinker and poet Hakim Bey (real name – Peter Lamborn Wilson, 1945–2022) and rather poorly represented in Russian-language scientific ...
D. B. Polyakov
doaj   +1 more source

The Hippo Pathway Effector Transcriptional Co-activator With PDZ-Binding Motif Correlates With Clinical Prognosis and Immune Infiltration in Colorectal Cancer

Frontiers in Medicine, 2022
The transcriptional co-activator with PDZ-binding motif (TAZ) is a downstream effector of the Hippo pathway. It has been identified as an oncogene in certain tumor types; however, the function and role of TAZ in colorectal cancer (CRC) has not been ...
Yutong Wang, Hui Nie, Huiling Li, Zhiming Liao, Xuejie Yang, Xiaoyun He, Jian Ma, Jianhua Zhou, Jianhua Zhou, Chunlin Ou, Chunlin Ou   +10 more
doaj   +1 more source

The sweet side of YAP/TAZ [PDF]

Cell Cycle, 2015
The reprogramming of cancer cell metabolism toward aerobic glycolysis, i.e. the Warburg effect, is a hallmark of cancer; the rationale for selecting such energy-inefficient metabolism is the need to increase cellular biomass and sustain the high proliferation rates of cancer cells.1 Metabolic reprogramming is generally considered as a phenotypic ...
Santinon G., Enzo E., Dupont S.
openaire   +4 more sources

Establishment of a coculture system for Porphyromonas gingivalis and head and neck squamous cell carcinoma using spheroid culture and LATS inhibition

FEBS Open Bio, EarlyView.
We established a spheroid coculture system enabling viable Porphyromonas gingivalis–HNSCC interactions under normoxic conditions. Inhibition of LATS1/2 maintains tumor cells in an undifferentiated state, which may promote spheroid growth and create a more permissive environment for bacterial persistence.
Yurika Nakajima, Shogo Okazaki, Muneaki Tamura, Shuichi Sato, Kenichi Imai   +4 more
wiley   +1 more source

TAZ promotes osteogenic differentiation of mesenchymal stem cells line C3H10T1/2, murine multi-lineage cells lines C2C12, and MEFs induced by BMP9

Cell Death Discovery, 2022
Bone morphogenetic protein 9 (BMP9), also named as growth differentiation factor 2 (GDF-2), is the strongest cytokine that promotes osteogenic differentiation in the BMP family, and has broad clinical application value.
Huakun Huang, Qiuping Lu, Caihong Ye, Mengqi Wei, Chunmei Yang, Lulu Zhang, Yanran Huang, Xiaoji Luo, Jinyong Luo   +8 more
doaj   +1 more source

The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential

Aging and Cancer, EarlyView.
As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
wiley   +1 more source