Results 91 to 100 of about 184,470 (334)

The Prognostic Significance of the TEAD4 in Hepatocellular Carcinoma

International Journal of General Medicine, 2023
Liping Lei,1,2,* Jingjing Yang,1,* Hao Peng,1 Ruiyan Huang,1 Lichun Liang,1 Ruifang Liu,1 Jiangfa Li1 1Department of Hepatobiliary and Pancreatic Surgery, The Affiliated Hospital of Guilin Medical University, Guilin, 541001, People’s Republic of ...
Lei L, Yang J, Peng H, Huang R, Liang L, Liu R, Li J   +6 more
doaj  

DNA-methylation for the detection and distinction of 19 human malignancies

Epigenetics, 2022
The contribution of DNA-methylation based gene silencing to carcinogenesis is well established. Increasingly, DNA-methylation is examined using genome-wide techniques, with recent public efforts yielding immense data sets of diverse malignancies ...
Ludmila Danilova, John Wrangle, James G. Herman, Leslie Cope   +3 more
doaj   +1 more source

Measures for the degree of overlap of gene signatures and applications to TCGA [PDF]

Briefings in Bioinformatics, 2014
For cancer and many other complex diseases, a large number of gene signatures have been generated. In this study, we use cancer as an example and note that other diseases can be analyzed in a similar manner. For signatures generated in multiple independent studies on the same cancer type and outcome, and for signatures on different cancer types, it is ...
Huangdi Yi, Xingjie Shi, Shuangge Ma
openaire   +3 more sources

EGFR‐STAT3 activation provides a therapeutic rationale for targeting aggressive ETV1‐positive prostate cancer

Molecular Oncology, EarlyView.
Cotargeting EGFR and STAT3 with Erlotinib and TTI‐101 impairs both 2D and 3D growth of ETV1‐overexpressing prostate cancer cells by disrupting a self‐sustaining ETV1–EGFR positive feedback loop that promotes EGFR and STAT3 expression and phosphorylation (activation).
Elsa Gomes Paiva, Bernardo Orr, Ana Azeredo, Andreia Brandão, Manuel R. Teixeira, Paula Paulo   +5 more
wiley   +1 more source

The immune infiltration in clear cell Renal Cell Carcinoma and their clinical implications: A study based on TCGA and GEO databases

Journal of Cancer, 2020
The tumor immune microenvironment in clear cell Renal Cell Carcinoma (ccRCC) still remains poorly understood. Previous methods to study the tumor immune microenvironment have a limitation when accounting for the functionally distinct cell types.
Qiufeng Pan, Longwang Wang, Shuaishuai Chai, Hao Zhang, Bing Li   +4 more
semanticscholar   +1 more source

Development and Validation of an Immune-Related Gene Pair Signature in Skin Cutaneous Melanoma

Clinical, Cosmetic and Investigational Dermatology, 2020
Ran Xie,1,* Suwei Dong,2,* Jie Jiang,3 Conghui Yang,1 Lanjiang Li,4 Sheng Zhao,1 Yunlei Li,3 Chun Wang,1 Shujuan Li,1 Yanbin Xiao,2 Long Chen1 1PET/CT Center, Yunnan Cancer Hospital, The Third Affiliated Hospital of Kunming Medical University, Cancer ...
Xie R, Dong S, Jiang J, Yang C, Li L, Zhao S, Li Y, Wang C, Li S, Xiao Y, Chen L   +10 more
doaj  

The developmental gene Chordin is amplified and expressed in human cancers

Molecular & Cellular Oncology, 2023
Chordin (CHRD) is a secreted protein important in early development, yet a role for CHRD in human disease has not been identified. In this study we investigated CHRD in cancer and normal adult tissues using the wealth of genome-wide data available in ...
Eric Sosa, Edward M. De Robertis
doaj   +1 more source

ITGAV and SMAD4 influence the progression and clinical outcome of pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
In SMAD4‐positive pancreatic ductal adenocarcinoma (PDAC), integrin subunit alpha V (ITGAV) activates latent TGF‐β, which binds to the TGF‐β receptor and phosphorylates SMAD2/3. The activated SMAD2/3 forms a complex with SMAD4, and together they translocate to the nucleus, modulating gene expression to promote proliferation, migration, and invasion. In
Daniel K. C. Lee, Keyue Chen, Ryan Loke, Xiang Li, David Liubart, Golam T. Saffi, Jonathan T. S. Chow, Ché M. P. Melo, Lydia To, Leonardo Salmena   +9 more
wiley   +1 more source

Mining TCGA database for genes of prognostic value in glioblastoma microenvironment

Aging, 2018
Glioblastoma (GBM) is one of the most deadly brain tumors. The convenient access to The Cancer Genome Atlas (TCGA) database allows for large-scale global gene expression profiling and database mining for potential correlation between genes and overall ...
Di Jia, Shenglan Li, Dali Li, Haipeng Xue, Dan Yang, Y. Liu   +5 more
semanticscholar   +1 more source

The critical role of DNA damage‐inducible transcript 4 (DDIT4) in stemness character of leukemia cells and leukemia initiation

Molecular Oncology, EarlyView.
Stemness properties, including quiescence, self‐renewal, and chemoresistance, are closely associated with leukemia relapse. Here, we demonstrate that DNA damage‐inducible transcript 4 (DDIT4) is induced in the hypoxic bone marrow niche and is essential for maintaining the stemness of AML1‐ETO9a leukemia cells.
Yishuang Li, Zhijie Cao, Haiyan Xing, Zhenya Xue, Wenbing Liu, Jiayuan Chen, Yihan Mei, Runxia Gu, Hui Wei, Shaowei Qiu, Min Wang, Qing Rao, Jianxiang Wang   +12 more
wiley   +1 more source