Results 91 to 100 of about 146,987 (295)

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Association between high immune activity and worse prognosis in uveal melanoma and low-grade glioma in TCGA transcriptomic data [PDF]

, 2022
Hitoshi Matsuo, Takashi Kamatani, Yu Hamba, Keith A. Boroevich, Tatsuhiko Tsunoda   +4 more
openalex   +1 more source

Gene expression liver cancer from TCGA

, 2021
Gene expression data of liver cancer obtained from ...
openaire   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

Ki-67 proliferation index to further stratify invasive breast cancer molecular subtypes: Northern African comparative cohort-study with external TCGA-BRCA and metabric validation

, 2022
Laila Akhouayri, Meriem Regragui, Samira Benayad, N. Bennani Guebessi, F. Marnissi, Giovanna Chiorino, Mehdi Karkouri   +6 more
openalex   +1 more source

NR4A1 Exerts Pro‐Tumor Role in Glioblastoma via Inducing xCT/GPX4‐Regulated Ferroptosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Purpose This study investigates NR4A1's paradoxical roles in glioblastoma (GBM) progression, focusing on its mechanistic link to ferroptosis regulation. We aimed to resolve conflicting reports of NR4A1 as both an oncogene and a tumor suppressor by defining its transcriptional control over xCT/GPX4‐mediated iron homeostasis and its clinical ...
Peng Tao, Shikuan Din, Zhengkang Fu, Qian Sun, Xiwei Zhu, Yuxin Wei, Huan Qu, Xinyi Zhang, Jiaxuan Liu, Chuhua Fu, Qianxue Chen   +10 more
wiley   +1 more source

Identification of DAPK1 Promoter Hypermethylation as a Biomarker for Intra-Epithelial Lesion and Cervical Cancer: A Meta-Analysis of Published Studies, TCGA, and GEO Datasets [PDF]

, 2018
Xuebin Wang, Ning‐hua Cui, Xia’nan Liu, Junfen Ma, Qinghua Zhu, Shuren Guo, Junwei Zhao, Ming Liang   +7 more
openalex   +1 more source

Supplementary Table S3 from Glioblastoma TCGA Mesenchymal and IGS 23 Tumors are Identifiable by IHC and have an Immune-phenotype Indicating a Potential Benefit from Immunotherapy

, 2023
Cristina Carrato, Francesc Alameda, Anna Esteve‐Codina, Estela Pineda, Oriol Arpí, Maria Martinez‐García, Mar Mallo, Marta Gut, Raquel López-Martos, Sonia Del Barco, Teresa Ribalta, Jaume Capellades, Josep Puig, Óscar Gallego, Carlos Mesía, Ana M Muñoz‐Mármol, Iván Archilla, Montserrat Arumí, Julie Blanc, Beatríz Bellosillo, Sílvia Menéndez, Anna Esteve, Sílvia Bagué, Ainhoa Hernández, Jordi Craven–Bartle, Rafael Fuentes, Noemí Vidal, Ibán Aldecoa, Núria de la Iglesia, Carmen Balañá   +29 more
openalex   +1 more source

The TCGA Meta-Dataset Clinical Benchmark

, 2019
5 Pages, Submitted to MLCB ...
Samiei, Mandana, Würfl, Tobias, Deleu, Tristan, Weiss, Martin, Dutil, Francis, Fevens, Thomas, Boucher, Geneviève, Lemieux, Sebastien, Cohen, Joseph Paul   +8 more
openaire   +2 more sources

Unraveling the Molecular Mechanisms of Glioma Recurrence: A Study Integrating Single‐Cell and Spatial Transcriptomics

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Glioma recurrence severely impacts patient prognosis, with current treatments showing limited efficacy. Traditional methods struggle to analyze recurrence mechanisms due to challenges in assessing tumor heterogeneity, spatial dynamics, and gene networks.
Lei Qiu, Yinjiao Fei, Jiaxuan Ding, Kexin Shi, Jinyan Luo, Yuchen Zhu, Xingjian Sun, Gefei Jiang, Yuandong Cao, Weilin Xu, Shu Zhou   +10 more
wiley   +1 more source