Results 61 to 70 of about 147,649 (246)

Suppression of tumor antigen presentation during aneuploid tumor evolution contributes to immune evasion

OncoImmunology, 2019
Anti-tumor immune responses impede tumor formation, and cancers have evolved many mechanisms of immune evasion. Confirming earlier findings, we show that human tumors with high chromosomal instability (CIN+) are significantly less immunogenic, as judged ...
Reshmi Tripathi, Vishnu Modur, Laura Senovilla, Guido Kroemer, Kakajan Komurov   +4 more
doaj   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Single nucleotide polymorphism mutation related genes in bladder cancer for the treatment of patients: a study based on the TCGA database

Biotechnology & Biotechnological Equipment, 2021
Bladder cancer (BLCA) is a common malignancy and has a poor prognosis. Single nucleotide polymorphisms (SNPs) in genes are closely associated with the tumorigenesis and tumor development and yet are not well illustrated in BLCA.
Tengyun Long, Xiaoni Li, Guofei Zhang, Chunming Qiu, Ouyang Huan, Canbiao Sun, Yong Yang   +6 more
doaj   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Integrated Analysis of miRNA and mRNA Expression Profiles Reveals the Molecular Mechanism of Posttraumatic Stress Disorder and Therapeutic Drugs

International Journal of General Medicine, 2022
Chunchun Gan,1 Zhan Jin,1 Gaobo Hu,1 Zheming Li,2 Minli Yan3 1Quzhou College of Technology, Quzhou, Zhejiang, 324000, People’s Republic of China; 2College of Pharmacy, Hangzhou Medical College, Hangzhou, Zhejiang, People’s Republic of China; 3Department ...
Gan C, Jin Z, Hu G, Li Z, Yan M
doaj  

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gabor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Long Non-Coding RNA Signatures Associated with Ferroptosis Predict Prognosis in Colorectal Cancer

International Journal of General Medicine, 2022
Na Li,1 Jiangli Shen,1 Ximin Qiao,2 Yuan Gao,3 Hong-Bo Su,4 Shuai Zhang5 1Department of Anorectal Surgery, Xianyang Central Hospital, Xianyang, Shaanxi Province, People’s Republic of China; 2Dean’s Office, Xianyang Central Hospital, Xianyang, Shaanxi ...
Li N, Shen J, Qiao X, Gao Y, Su HB, Zhang S   +5 more
doaj  

Reproducible processing of TCGA regulatory networks

GigaScience
AbstractBackgroundTechnological advances in sequencing and computation have allowed deep exploration of the molecular basis of diseases. Biological networks have proven to be a useful framework for interrogating omics data and modeling regulatory gene and protein interactions.
Viola Fanfani, Katherine H Shutta, Panagiotis Mandros, Jonas Fischer, Enakshi Saha, Soel Micheletti, Chen Chen, Marouen Ben Guebila, Camila M Lopes-Ramos, John Quackenbush   +9 more
openaire   +2 more sources

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source