Results 61 to 70 of about 184,470 (334)
Prognostic Role of Immune-related Genes in Hepatocellular Carcinoma
Zhongliu Fangzhi Yanjiu, 2022 Objective To identify the potential prognostic biomarkers of the immune-related genes signature for patients with hepatocellular carcinoma (HCC). Methods Original HCC data were downloaded from TCGA, and the immune activity of each sample was calculated ...
WANG Jue +8 more
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Next generation sequencing and ‘race’ in TCGA
, 2022 In this Commentary, the author brings some criticism to the concept of 'race' used in genomic studies of the TCGA and tries to demonstrate that it is not valid from scientific, sociologic and philosophic points of view.
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Mathematical Biosciences and Engineering, 2022 Skin cutaneous melanoma (SKCM) is one of the most malignant skin cancers and remains a health concern worldwide. Pyroptosis is a newly recognized form of programmed cell death and plays a vital role in cancer progression. We aim to construct a prognostic
Zehao Niu +4 more
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Molecular Oncology, EarlyView.Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley +1 more source
Identification of an immune-related signature for the prognosis of uveal melanoma [PDF]
International Journal of Ophthalmology, 2020 "AIM: To construct an immune-related prognostic signature (IPS) that can distinguish and predict prognosis in uveal melanoma (UM). METHODS: The transcriptomic data and clinicopathological information of 80 UM patients were extracted from the TCGA ...
Ying-Zi Li +3 more
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Mining TCGA Data Using Boolean Implications
PLoS ONE, 2014 Boolean implications (if-then rules) provide a conceptually simple, uniform and highly scalable way to find associations between pairs of random variables. In this paper, we propose to use Boolean implications to find relationships between variables of different data types (mutation, copy number alteration, DNA methylation and gene expression) from the
Sinha, Subarna +4 more
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Molecular Oncology, EarlyView.Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser +11 more
wiley +1 more source
A suite of DNA methylation markers that can detect most common human cancers
Epigenetics, 2018 Cancer-specific DNA methylation from the tumor derived fraction of cell free DNA found in blood samples could be used for minimally invasive detection and monitoring of cancer.
Lukas Vrba, Bernard W. Futscher
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Promising markers of CIMP+ colon tumors identified on the basis of TCGA data analysis
Вавиловский журнал генетики и селекции, 2018 CIMP+ (CpGIsland Methylator Phenotype) tumors are characterized by dense methylation of promoter CpG islands of many genes at once and represent a separate group of malignant neoplasms of the colon.
G. S. Krasnov +6 more
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Frontiers in Bioscience-Landmark, 2023 Background: The purpose of our study is to analyze the expression pattern and prognostic value of catabolism-related enzymes of branched-chain amino acids (BCAAs) in non-small cell lung cancer (NSCLC). Methods: Differential expression analysis, mutation,
Xiaojun Yao +4 more
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