Results 1 to 10 of about 330,751 (185)
Co-receptor CD8-mediated modulation of T-cell receptor functional sensitivity and epitope recognition degeneracy [PDF]
, 2013 The interaction between T-cell receptors (TCRs) and peptide epitopes is highly degenerate: a TCR is capable of interacting productively with a wide range of different peptide ligands, involving not only cross-reactivity proper (similar epitopes elicit ...
Berg, Hugo van den +3 more
core +7 more sources
The Simplicity of Divine Ideas: Theistic Conceptual Realism and The Doctrine of Divine Simplicity [PDF]
, 2021 There has been little discussion of the compatibility of Theistic Conceptual Realism (TCR) with the doctrine of divine simplicity (DDS). On one hand, if a plurality of universals is necessary to explain the character of particular things, there is ...
Panchuk, Michelle Lynn
core +1 more source
Frontiers in Immunology, 2020 Mesenchymal stromal cells (MSCs) are rare precursors in all organs of the body. MSCs have profound anti-inflammatory effects and reduce alloreactivity in vitro and in vivo.
Olle Ringdén +2 more
doaj +1 more source
TCR Antagonism by Peptide Requires High TCR Expression [PDF]
The Journal of Immunology, 2008 AbstractCurrent models of T cell activation focus on the kinetics of TCR-ligand interactions as the central parameter governing T cell responsiveness. However, these kinetic parameters do not adequately predict all T cell behavior, particularly the response to antagonist ligands.
Daniel S, Jones +4 more
openaire +2 more sources
Adoptivna celična terapija in limfociti T z izraženimi himernimi antigenskimi receptorji
Zdravniški Vestnik, 2020 Pri zdravljenju raka se trenutno uporabljajo pristopi kirurškega zdravljenja, radio- in kemoterapije ter različne kombinacije teh pristopov. Kot 'četrti steber' onkološkega zdravljenja se razvija imunoterapija.
Uroš Rajčević
doaj +1 more source
TCR–pMHC bond conformation controls TCR ligand discrimination [PDF]
Cellular & Molecular Immunology, 2019 Abstract A major unanswered question is how a TCR discriminates between foreign and self-peptides presented on the APC surface. Here, we used in situ fluorescence resonance energy transfer (FRET) to measure the distances of single TCR–pMHC bonds and the conformations of individual TCR–CD3ζ receptors at the membranes of live primary T ...
Dibyendu K. Sasmal +12 more
openaire +2 more sources
Immune repertoire: Revealing the “real-time” adaptive immune response in autoimmune diseases
Autoimmunity, 2021 The diversity of the immune repertoire (IR) enables the human immune system to distinguish multifarious antigens (Ags) that humans may encounter throughout life.
Meiyu Wu +3 more
doaj +1 more source
Pre‐clustered TCR complexes [PDF]
FEBS Letters, 2010 The T‐cell antigen receptor (TCR) is a multisubunit transmembrane complex that mediates the antigen‐specific activation of T cells. Using a variety of techniques, several research groups have shown that TCRs are at least partially pre‐clustered before antigen binding. These new findings are contradictory to the “classical” view, according to which TCRs
Molnár, Eszter +2 more
openaire +3 more sources
Comparing CAR and TCR engineered T cell performance as a function of tumor cell exposure
OncoImmunology, 2022 Chimeric antigen receptor (CAR) T cell therapies have resulted in profound clinical responses in the treatment of CD19-positive hematological malignancies, but a significant proportion of patients do not respond or relapse eventually.
Tassilo L. A. Wachsmann +9 more
doaj +1 more source
Synthetic TRuC receptors engaging the complete T cell receptor for potent anti-tumor response
Nature Communications, 2019 Supraphysiological T cell activation by chimeric antigen receptor (CAR) contributes to T cell exhaustion and adverse events in CAR T cell therapies. Here the authors engineer a synthetic antigen receptor that integrates into the endogenous TCR complex ...
Patrick A. Baeuerle +20 more
doaj +1 more source