Results 121 to 130 of about 330,850 (283)

Insertion/deletion-related polymorphisms in the human T cell receptor beta gene complex. [PDF]

, 1989
Insertion/deletion related polymorphisms (IDRP) involving stretches of 15-30 kb within the human TCR-beta gene complex were revealed by pulse-field gel electrophoresis.
Hauser, SL, Kindt, TJ, Robinson, MA, Seboun, E   +3 more
core  

Reorientation of Spin Density Waves in Cr(001) Films induced by Fe(001) Cap Layers

, 1998
Proximity effects of 20 \AA thin Fe layers on the spin density waves (SDWs) in epitaxial Cr(001) films are revealed by neutron scattering. Unlike in bulk Cr we observe a SDW with its wave vector Q pointing along only one {100} direction which depends ...
A. Berger, A. Davies, A. Hucht, A. Schreyer, A. Schreyer, A. Stierle, A. Vega, D. Stoeffler, D. Venus, E. E. Fullerton, E. E. Fullerton, E. Fawcett, F. Güthoff, G. Binasch, H. Zabel, J. Borchers, J. C. Slonczewski, J. Meersschaut, J. Unguris, K. Theis-Bröhl, M. D. Stiles, M. Freyss, M. Freyss, M. N. Baibich, P. Bödeker, P. Sonntag, R. Jungblut, S. M. Durbin, S. M. Durbin, Z. P. Shi   +29 more
core   +1 more source

ETV1 Drives CD4+ T Cell‐Mediated Intestinal Inflammation in Inflammatory Bowel Disease Through Amino Acid Transporter Slc7a5

Advanced Science, EarlyView.
This study identifies the transcription factor ETV1 as a key driver of CD4⁺ T cell‐mediated intestinal inflammation in inflammatory bowel disease (IBD). ETV1 promotes CD4⁺ T cell activation, proliferation, and Th17 differentiation by activating the amino acid transporter SLC7A5, fueling metabolic reprogramming.
Yan Shi, Song Wang, Yuqing Yan, Wei Chen, Yingying Cao, Dafan Chen, Wei Chen, Caiyun Ma, Xinjian Wan   +8 more
wiley   +1 more source

The Testosterone: Cortisol Ratio - A Tool with Practical Use and Research Potential in Endocrinology

Indian Journal of Endocrinology and Metabolism
Testosterone is a predominantly anabolic hormone whereas cortisol is a catabolic hormone. Measurement of testosterone-cortisol ratio (TCR) can serve as a surrogate for the balance in the anabolic: catabolic states in the body and was studied as a marker ...
Sunetra Mondal, Deep K. Hathi, Saptarshi Bhattacharya, Sanjay Kalra   +3 more
doaj   +1 more source

The mutational status of p53 can influence its recognition by human T-cells

OncoImmunology, 2017
p53 was reported to be an attractive immunotherapy target because it is mutated in approximately half of human cancers, resulting in its inactivation and often accumulation in tumor cells.
Katerina Shamalov, Shlomo N. Levy, Miryam Horovitz-Fried, Cyrille J. Cohen   +3 more
doaj   +1 more source

Elemene Augments the Effects of Anti‐PD‐1 Immunotherapy on Hepatocellular Carcinoma by Regulating the miR‐130a‐5p/SPP/MHC‐I Axis

Advanced Science, EarlyView.
Elemene increases SPP expression by competitively binding with miR‐130a‐5p to suppress SPP mRNA degradation. This led to more antigen/MHC‐I complexes being expressed on the cell surface, which consequently facilitated the recognition and killing of HCC cells by CTLs and enhancing the antitumor immune efficacy of anti‐PD‐1.
Menglan Wang, Mengqing Sun, Heng Dong, Xiaoting Zhang, Jingbo Zhang, Zhengguo Zhang, Mengjie Ni, Lina Li, Yunxin Pei, Xiaoyu Chen, Qian Li, Fangtian Bu, Jiacheng Huang, Liangyu Jiang, Zhuting Fang, Xuliang Chen, Jianxiang Chen, Yiting Qiao, Tian Xie   +18 more
wiley   +1 more source

A Lung‐Immune Dual‐Humanized Mouse Using Cryopreserved Tissue Enables Infection and Immune Profiling of Human Common Cold Coronaviruses

Advanced Science, EarlyView.
Cryopreserved lung‐humanized mice overcome the dependency to fresh tissues and permit head‐to‐head profiling of all four human common cold coronaviruses versus SARS‐CoV‐2 infection; the model validates Paxlovid efficacy against HKU1 and, when coupled with human immune‐system engraftment, enables interrogation of lung‐resident human immunity and HKU1 ...
Chunyu Cheng, Jing Sun, Chun Lu, Qian Yu, Yiyun He, Bingqing Wu, Deshan Ren, Shuai Ding, Jincun Zhao, Yan Li   +9 more
wiley   +1 more source

Engineering Osteoimmune Responses with Functionalized Orthopedic Implants for Post‐Operative Osteosarcoma Treatment

Advanced Science, EarlyView.
Osteosarcoma is the most common primary bone tumor with limited treatment options and a terrible prognosis. This review provides a comprehensive summary of the recent development of osteoimmunomodulatory implants for post‐operative osteosarcoma treatment, of which the potential utility in evoking durable anti‐osteosarcoma immunity and accelerating bone
Yilong Dong, Lingshuang Wang, Hui Zhang, Menghuan Li, Zhong Luo, Yan Hu, Chunyuan Cai   +6 more
wiley   +1 more source

Correlations in the T Cell Response to Altered Peptide Ligands

, 2004
The vertebrate immune system is a wonder of modern evolution. Occasionally, however, correlations within the immune system lead to inappropriate recruitment of preexisting T cells against novel viral diseases.
Arstila, Bachmann, Bachmann, Blattman, Bogarad, Chandler, Deem, Derrida, Derrida, Drossel, Garboczi, Garcia, Jeong-Man Park, Kauffman, Kedl, Kesmir, Klenerman, Lee, Lee, Martin, Michael W. Deem, Perelson, Perelson, Schodin, Singh, Sloan-Lancaster, Sourdive   +26 more
core   +1 more source

METTL5 Enables Immune Evasion of Liver Cancer via Chemokine mRNA Translation Regulation

Advanced Science, EarlyView.
METTL5 reshapes the tumor immune microenvironment through ribosome 18S rRNA m6A modification to regulate the translation of chemokine mRNA. Targeting METTL5‐mediated immunosuppression unleashes anti‐tumor immunity and improves the efficacy of anti‐PD‐1 therapy.
Shuang Li, Xiao Zhao, Tongtong Song, Qiaoyi Chen, Yanqing Wu, Yuting Zhang, Jingying Chen, Yifan Wu, Bin Li, Xinyue Zhang, Zihao Dai, Lixia Xu, Yubin Xie, Alfred Sze‐Lok Cheng, Jianping Guo, Ming Kuang, Shuibin Lin, Zhenwei Peng, Sui Peng, Xuezhen Zeng   +19 more
wiley   +1 more source