Frontiers in Immunology, 2017 Mesenchymal stromal cells (MSCs) are increasingly used in regenerate medicine. Placenta-derived decidual stromal cells (DSCs) are a novel therapy for acute graft-versus-host-disease (GVHD) and hemorrhagic cystitis (HC) after allogeneic hematopoietic stem
Arjang Baygan +15 more
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Targeting KRAS mutations with HLA class II-restricted TCRs for the treatment of solid tumors
OncoImmunology, 2021 T-cell receptor (TCR) redirected T cells are considered as the next generation of care for the treatment of numerous solid tumors. KRAS mutations are driver neoantigens that are expressed in over 25% of all cancers and are thus regarded as ideal targets ...
Pierre Dillard +7 more
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Antigen receptor variable region repertoires expressed by T cells infiltrating thyroid, retroorbital, and pretibial tissue in Graves' disease [PDF]
, 1996 To date, it has remained unclear whether T cells infiltrating thyroid, retroorbital, and pretibial tissue of patients with Graves' ophthalmopathy and pretibial dermopathy represent a primary immune response that is directed against certain antigenic ...
Heufelder, Armin E. +2 more
core +1 more source
Pathogenic CD8 T cells in Multiple Sclerosis and its experimental models
Frontiers in Immunology, 2012 A growing body of evidence suggests that autoreactive CD8 T cells contribute to the disease process in Multiple Sclerosis (MS). Lymphocytes in MS plaques are biased toward the CD8 lineage, and MS patients harbor CD8 T cells specific for multiple central ...
Eric S. Huseby +4 more
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Effect of Cr spacer on structural and magnetic properties of Fe/Gd multilayers [PDF]
, 2018 In this work we analyse the role of a thin Cr spacer between Fe and Gd layers on structure and magnetic properties of a [Fe(35A)/Cr(tCr)/Gd(50A)/Cr(tCr)]x12 superlattice. Samples without the Cr spacer (tCr=0) and with a thin tCr=4A are investigated using
Choi, Y. +12 more
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Destabilizing the autoinhibitory conformation of Zap70 induces up-regulation of inhibitory receptors and T cell unresponsiveness. [PDF]
, 2017 Zap70 plays a critical role in normal T cell development and T cell function. However, little is known about how perturbation of allosteric autoinhibitory mechanisms in Zap70 impacts T cell biology.
Chen, Yiling +4 more
core +2 more sources
Initiation of TCR phosphorylation and signal transduction
Frontiers in Immunology, 2011 Recent data with CD8+ T cells show that the initial phase of TCR binding to MHCp is quickly followed by a second, stronger, binding phase representing the binding of CD8 to the MHCp. This second phase requires signaling by a Src-family kinase such as Lck.
Nicholas R.J. Gascoigne +3 more
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Evaluating metabolites in patients with major depressive disorder who received mindfulness-based cognitive therapy and healthy controls using short echo MRSI at 7 Tesla. [PDF]
, 2016 ObjectivesOur aim was to evaluate differences in metabolite levels between unmedicated patients with major depressive disorder (MDD) and healthy controls, to assess changes in metabolites in patients after they completed an 8-week course of mindfulness ...
Eisendrath, Stuart +6 more
core +3 more sources
The Binding Effect of the Constitutive Documents of Companies: The 1973 and 2008 Companies Acts of South Africa [PDF]
Potchefstroom Electronic Law Journal, 2010 This contribution examines the provisions of the constitutive documents of companies under two specific provisions, namely s 65(2) of the Companies Act 61 of 1973 and s 15(6) of the Companies Act 71 of 2008.
TCR Morajane
doaj
REVISITING THE PUTATIVE TCR Cα DIMERIZATION MODEL THROUGH STRUCTURAL ANALYSIS
Frontiers in Immunology, 2013 Despite major advances in T cell receptor (TCR) biology and structure, how peptide-MHC complex (pMHC) ligands trigger αβ TCR activation remains unresolved. Two views exist. One model postulates that monomeric TCR-pMHC ligation events are sufficient while
Jia-huai eWang, Ellis L Reinherz
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