Results 21 to 30 of about 330,850 (283)
Nuclear pore complex-mediated modulation of TCR signaling is required for naïve CD4+ T cell homeostasis. [PDF]
, 2018 Nuclear pore complexes (NPCs) are channels connecting the nucleus with the cytoplasm. We report that loss of the tissue-specific NPC component Nup210 causes a severe deficit of naïve CD4+ T cells.
Borlido, Joana +6 more
core +1 more source
Competitive Displacement of pTα by TCR-α During TCR Assembly Prevents Surface Coexpression of Pre-TCR and αβ TCR [PDF]
The Journal of Immunology, 2000 AbstractDuring αβ T cell development, CD4−CD8− thymocytes first express pre-TCR (pTα/TCR-β) before their differentiation to the CD4+CD8+ stage. Positive selection of self-tolerant T cells is then determined by the αβ TCR expressed on CD4+CD8+ thymocytes.
Sébastien Trop +4 more
openaire +1 more source
OncoImmunology, 2020 Clinical observations suggest that responses to cancer immunotherapy are correlated with intra-tumoral T cell receptor (TCR) clonality, tumor mutation burden (TMB) and host HLA genotype, highlighting the importance of host T cell recognition of tumor ...
Xuan Ye +14 more
doaj +1 more source
Redistribution of critical major histocompatibility complex and T cell receptor-binding functions of residues in an antigenic sequence after biterminal substitution [PDF]
, 1991 Residues critical for establishing a trimolecular interaction with a major histocompatibility complex (MHC)-encoded receptor and a T cell antigen receptor (TcR) were determined for an antigenic nonapeptide. The N-terminal residue proved to be involved in
Allen +18 more
core +1 more source
TCR-like CARs and TCR-CARs targeting neoepitopes: an emerging potential [PDF]
Cancer Gene Therapy, 2021 AbstractNeoepitopes or neoantigens are a spectrum of unique mutations presented in a particular patient’s tumor. Neoepitope-based adoptive therapies have the potential of tumor eradication without undue damaging effect on normal tissues. In this context, methods based on the T cell receptor (TCR) engineering or chimeric antigen receptors (CARs) have ...
Mansour Poorebrahim +5 more
openaire +3 more sources
Frontiers in Immunology, 2013 Since the discovery of co-receptor dependent αβTCR recognition, considerable effort has been spent on elucidating the basis of CD4 and CD8 lineage commitment in the thymus.
Xiao-long eLi +6 more
doaj +1 more source
Existence of negative differential thermal conductance in one-dimensional diffusive thermal transport [PDF]
, 2012 We show that in a finite one-dimensional (1D) system with diffusive thermal transport described by the Fourier's law, negative differential thermal conductance (NDTC) cannot occur when the temperature at one end is fixed. We demonstrate that NDTC in this
Jiuning Hu, W. Walter, Yong P. Chen
core +3 more sources
AutoCAT: automated cancer-associated TCRs discovery from TCR-seq data
Bioinformatics, 2021 AbstractSummaryT cells participate directly in the body's immune response to cancer, allowing immunotherapy treatments to effectively recognize and target cancer cells. We previously developed DeepCAT to demonstrate that T cells serve as a biomarker of immune response in cancer patients and can be utilized as a diagnostic tool to differentiate healthy ...
Christina Wong, Bo Li
openaire +2 more sources
Human Vaccines & Immunotherapeutics, 2022 Multiple types of SARS-CoV-2 vaccines have been used worldwide, but summarizing their immunologic efficacy post-vaccination remains challenging. The BCR and TCR sequencing based on single-cell sorting makes it possible to evaluate the vaccine-induced ...
Li Qin +9 more
doaj +1 more source
IL-15 augments TCR-induced CD4⁺ T cell expansion in vitro by inhibiting the suppressive function of CD25High CD4⁺ T cells [PDF]
, 2012 Due to its critical role in NK cell differentiation and CD8(+) T cell homeostasis, the importance of IL-15 is more firmly established for cytolytic effectors of the immune system than for CD4(+) T cells. The increased levels of IL-15 found in several CD4(
Boonefaes, Tom +5 more
core +2 more sources