Results 31 to 40 of about 330,850 (283)

T cell receptor richness in peripheral blood increases after cetuximab therapy and correlates with therapeutic response

OncoImmunology, 2018
The role of T cell receptor (TCR) signaling for adaptive immune responses is essential. The ability to respond to a broad spectrum of tumor antigens requires an adaptive selection of various TCR. So far, little is known about the role of TCR richness and
Benjamin A. Kansy, Gulidanna Shayan, Hyun-Bae Jie, Sandra P. Gibson, Yu L. Lei, Sven Brandau, Stephan Lang, Nicole C Schmitt, Fei Ding, Yan Lin, Robert L. Ferris   +10 more
doaj   +1 more source

Dynamic perturbations of the T-cell receptor repertoire in chronic HIV infection and following antiretroviral therapy.

Frontiers in Immunology, 2016
HIV infection profoundly affects many parameters of the immune system and ultimately leads to AIDS, yet which factors are most important for determining resistance, pathology and response to antiretroviral treatment – and how best to monitor them ...
James Malcolm Heather, Katharine eBest, Theres eOakes, Eleanor R Gray, Jennifer eRoe, Niclas eThomas, Nir eFriedman, Mahdad eNoursadeghi, Benny eChain   +8 more
doaj   +1 more source

New simplified molecular design for functional T cell receptor [PDF]

, 1993
We have produced a chimeric single-chain T cell receptor (TcR) that combines the specific antibody recognition function and TcR/CD3 signaling properties within the same polypeptide chain.
Clevers, Cosson, Eshhar, Frank, Gillis, Gunning, Hackett, Huston, Ihle, Irving, Lanzavecchia, Leo, Mosmann, Oi, Romeo, Sterz, Tada, Traunecker, Walker, Wegener, Weissman, Weissman, White, Zamoyska   +23 more
core   +1 more source

On the extraction of resistivity and area of nanoscale interconnect lines by temperature-dependent resistance measurements

, 2018
Several issues concerning the applicability of the temperature coefficient of the resistivity (TCR) method to scaled interconnect lines are discussed. The central approximation of the TCR method, the substitution of the interconnect wire TCR by the bulk ...
Adelmann, Christoph
core   +1 more source

Gli2, hedgehog and TCR signalling [PDF]

, 2015
Editoria
Crompton, Tessa, Furmanski, Anna L.
core   +2 more sources

Forward vaccinology: CTL targeting based upon physical detection of HLA-bound peptides

Frontiers in Immunology, 2014
Vaccine-elicited cytotoxic T lymphocytes (CTL) recognizing conserved fragments of a pathogen's proteome could greatly impact infectious diseases and cancers.
Ellis L Reinherz, Derin B Keskin, Bruce eReinhold   +2 more
doaj   +1 more source

T-cell subpopulations αβ and γδ in cord blood of very preterm infants : The influence of intrauterine infection [PDF]

, 2013
Open Access: This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are creditedPreterm infants are very ...
A Kotiranta-Ainamo, Agata Serwatowska-Bargieł, B Mazur, BJ Stoll, C Cairo, C Koehler, C Nakasone, CL Langrish, DJ Sherman, DL Gibbons, E Juretic, Elżbieta Górska, ER Newton, F Jouen-Beades, G Locksmith, GA Follows, H Zaghouani, J Chipeta, L Marodi, M Snyder, Maria Katarzyna Kornacka, Maria Wąsik, N Xiong, NC Maxwell, PJ Duggan, R Romero, RA Polin, RL Goldenberg, RL Schelonka, Robert Kozarski, RS Baltimore, S Beetz, SC Rosa De, T Matsuoka, TA Moore, Y Konigshofer, Y Zhao   +36 more
core   +1 more source

Evidence that the T cell antigen receptor may not be involved in cytotoxicity mediated by gamma/delta and alpha/beta thymic cell lines. [PDF]

, 1987
After culture in IL-2, thymocytes expressing either TCR-alpha/beta or -gamma/delta acquired the ability to lyse hematopoietic and solid tumor cell targets without deliberate immunization or apparent restriction by the MHC.
Gemlo, BT, Lanier, LL, Phillips, JH, Rayner, AA, Weiss, A   +4 more
core   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Immunoregulatory functions for murine intraepithelial lymphocytes: gamma/delta T cell receptor-positive (TCR+) T cells abrogate oral tolerance, while alpha/beta TCR+ T cells provide B cell help. [PDF]

, 1992
Past work has shown that a subset of effector T cells with unique characteristics could abrogate hapten- or antigen-induced tolerance, and the reconstitution of this immune response has been termed contrasuppression.
Aicher, WK, Bluestone, JA, Eldridge, JH, Fujihashi, K, Kiyono, H, McGhee, JR, Taguchi, T   +6 more
core