Chronic Inflammation: A Common Promoter in Tertiary Lymphoid Organ Neogenesis [PDF]
Frontiers in Immunology, 2019 Tertiary lymphoid organs (TLOs) frequently develop locally in adults in response to non-resolving inflammation. Chronic inflammation leads to the differentiation of stromal fibroblast cells toward lymphoid tissue organizer-like cells, which interact with
Shanshan Luo +7 more
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Role of CXCL13 in the formation of the meningeal tertiary lymphoid organ in multiple sclerosis [version 3; referees: 2 approved] [PDF]
F1000Research, 2018 Immunomodulatory therapies available for the treatment of patients with multiple sclerosis (MS) accomplish control and neutralization of peripheral immune cells involved in the activity of the disease cascade but their spectrum of action in the ...
Ana C. Londoño, Carlos A. Mora
doaj +3 more sources
Understanding Immune Cells in Tertiary Lymphoid Organ Development: It’s All Starting to Come Together [PDF]
Frontiers in Immunology, 2016 Tertiary lymphoid organs (TLOs) are frequently observed in tissues affected by non-resolving inflammation as a result of infection, autoimmunity, cancer and allograft rejection.
Gareth Wyn Jones +2 more
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Identification of novel genes associated with renal tertiary lymphoid organ formation in aging mice. [PDF]
PLoS ONE, 2014 A hallmark of aging-related organ deterioration is a dysregulated immune response characterized by pathologic leukocyte infiltration of affected tissues. Mechanisms and genes involved are as yet unknown.
Yuan Huang +9 more
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Meta-Analysis of Single-Cell RNA-Seq Data Reveals the Mechanism of Formation and Heterogeneity of Tertiary Lymphoid Organ in Vascular Disease. [PDF]
Arterioscler Thromb Vasc Biol, 2023 BACKGROUND: Tertiary lymphoid organs (TLOs) are ectopic lymphoid organs developed in nonlymphoid tissues with chronic inflammation, but little is known about their existence in different types of vascular diseases and the mechanism that mediated their ...
Sun X +15 more
europepmc +2 more sources
Chronic stress induces colonic tertiary lymphoid organ formation and protection against secondary injury through IL-23/IL-22 signaling. [PDF]
Proc Natl Acad Sci U S A, 2022 Significance Here, we demonstrate that chronic stress induces the formation of tertiary lymphoid organs (TLOs) in the colon of a mouse model of Crohn’s disease (CD)-like ileitis.
Gomez-Nguyen A +11 more
europepmc +2 more sources
The roles of tertiary lymphoid structures in orchestrating immune responses in peripheral organs [PDF]
Inflammation and RegenerationTertiary lymphoid structures (TLSs) are ectopic lymphoid aggregates that develop in non-lymphoid organs under pathological conditions of chronic inflammation, such as cancer, autoimmune diseases, chronic infections, organ transplantation, and age-related
Keisuke Taniguchi +2 more
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Adipose Tissue: A Tertiary Lymphoid Organ: Does It Change with Age? [PDF]
Gerontology, 2020 In this manuscript, we summarize published results showing that obesity and aging are inflammatory conditions associated with serious health problems, increased risk for disease and death.
Frasca D, Blomberg BB.
europepmc +2 more sources
Lymphatic impairment leads to pulmonary tertiary lymphoid organ formation and alveolar damage. [PDF]
J Clin Invest, 2019 The lung is a specialized barrier organ that must tightly regulate interstitial fluid clearance and prevent infection in order to maintain effective gas exchange. Lymphatic vessels are important for these functions in other organs, but their roles in the
Reed HO +10 more
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Identification of key genes and pathways contributing to artery tertiary lymphoid organ development in advanced mouse atherosclerosis. [PDF]
Mol Med Rep, 2019 Atherosclerosis is a leading cause of mortality worldwide. Artery tertiary lymphoid organ (ATLO) neogenesis is affected by abdominal aorta atherosclerosis, which may lead to an immune response.
Zhang X, Liu F, Bai P, Dong N, Chu C.
europepmc +2 more sources